Genetics: From Genes to Genomes
Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 22, Problem 8P
Summary Introduction

a.

To determine:

The reason for Eq. 22.7 being true for the extreme case where phenotypic variations are caused because of genes.

Introduction:

In some cases in a single pregnancy, two children are born. These children born in a single pregnancy are called twins. They can be monozygotic or dizygotic.

Summary Introduction

b.

To determine:

The reason for Eq. 22.7 being true for the extreme case where no phenotypic variations are caused because of genes.

Introduction:

Twins are those children that are born in the same pregnancy. If a single zygote splits into two to form two different embryos, then it is a case of monozygotic twins (MZ). On the other hand, if the embryos are formed by two fertilizations taking place in the same uterus, then the twins born are known as the dizygotic twins (DZ).

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ADHD is a highly heritable trait with published broad sense heritability estimates in the range of 0.6- 0.9. Larsson et al. 2014 (doi: 10.1017/S0033291713002493 ) reported the concordance values shown in the table below for pairs of monozygotic (MZ) or dizygotic (DZ) twins with data for male and female pairs shown separately, using data from the Swedish twin register (59,000 twin pairs, born between 1959 and 2001). Male MZ twins Male DZ twins Female MZ twins Female DZ twins 56% 16% 37% 13% Based on the data in this table, does ADHD appear to be more heritable in males or females? Provide one sentence of rationale to support your answer.
Please refer to the table below. If only data on the variances for F1, F2 and BC1 populations were available, how will the broad sense heritability estimate change? Show solutions.
Figure 19-11 shows the expected distributions for thethree genotypic classes if the B locus is a QTL affectingthe trait value.a. As drawn, what is the dominance/additive (D/A)ratio?b. How would you redraw this figure if the B locus hadno effect on the trait value?c. How would the positions along the x-axis of thecurves for the different genotypic classes of the B locuschange if D/A = 1.0?

Chapter 22 Solutions

Genetics: From Genes to Genomes

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