Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Question
Chapter 22, Problem 25P
Summary Introduction
To determine:
The two possible reasons due to which the –log10 (p value) in the second study was less than the cutoff.
Introduction:
One of the first large-scale GWAS explorations of human diseases analyzed about 1 million SNPs for each of seven complex diseases. These diseases include coronary artery disease. The –log10 (p-value) was used to estimate the statistical significance of the study.
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A SNP that can exist as a C or G is associated with a human disease. The genotypic odds ratio of the homozygote CC relative to the homozygote GG is 2.2, which indicates that
a)both CC and GG individuals are equally likely to get the disease because 2.2 is not a significant value.
b)heterozygotes are 2.2 times as likely to get the disease as GG homozygotes.
c) CC homozygotes are 2.2 times as likely to get the disease as GG homozygotes.
d) CC homozygotes are 2.2 times less likely to get the disease as GG homozygotes.
16.9 A human STR locus contains a tandem repeat (TAGA),„,
where n may be any number between 5 and 15. How
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With the information that a Wright- Fisher population have a size of 10,000 and assume that mutation rate is 2.5x10-8 per site per generation. What is the probability of difference between the two sequences that were randomly taken from the population? Show all working and explanation.
Chapter 22 Solutions
Genetics: From Genes to Genomes
Ch. 22 - Choose the best matching phrase in the right...Ch. 22 - Suppose you grew genetically identical dandelion...Ch. 22 - How can each of the following be used in...Ch. 22 - Two different groups of scientists studying a rare...Ch. 22 - Which of the following statements would be true of...Ch. 22 - Studies have indicated that for pairs of twins...Ch. 22 - Prob. 7PCh. 22 - Prob. 8PCh. 22 - Table 22.2 lists concordance values for MZ and DZ...Ch. 22 - Prob. 10P
Ch. 22 - Prob. 11PCh. 22 - Two alleles at one locus produce three distinct...Ch. 22 - In a certain plant, leaf size is determined by...Ch. 22 - Compare and contrast the use of SNP genotyping: i...Ch. 22 - Explain the similarities and differences between...Ch. 22 - In Fig. 22.14c, the fw2.2 causal gene was...Ch. 22 - Among the most prevalent pathologies that afflict...Ch. 22 - Human geneticists have found the Finnish...Ch. 22 - Canavan disease, caused by homozygosity for a...Ch. 22 - In GWAS analysis, because of the existence of LD...Ch. 22 - In Fig. 22.15: a. Why do some chromosomes in the...Ch. 22 - Consider the triangle diagram shown in Fig. 22.17....Ch. 22 - Prob. 23PCh. 22 - You conduct a Case/Control study comparing the...Ch. 22 - Prob. 25PCh. 22 - ALS amyotrophic lateral sclerosis is a rare, fatal...Ch. 22 - Through GWAS explorations, scientists have...Ch. 22 - In domesticated dogs, size has a high...Ch. 22 - Suppose a GWAS investigation found a particular LD...Ch. 22 - In 2008, Time magazine named as its invention of...
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