Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 21, Problem 15P
A gene has two alleles A (frequency = p) and a (frequency = q). If a population is at Hardy-Weinberg equilibrium, develop mathematical expressions in terms of p and q that predict the following mating frequencies:
| a. | Between two AA homozygotes |
| b. | Between two aa homozygotes |
| c. | Between two Aa heterozygotes |
| d. | Between an AA homozygote and an aa homozygote |
| e. | Between an AA homozyote and an Aa heterozygote |
| f. | Between an aa homozygote and an Aa heterozygote |
| Considering your answers to parts (a)–(f): | |
| g. | Do the six possibilities listed account for all possible matings? How would you know whether this is true mathematically? Demonstrate this latter point by setting p equal to an arbitrary number between 0 and 1 such as 0.2. |
| h. | Can you develop a simple, general rule for calculating the mating frequencies between individuals of the same genotype versus the mating frequencies between individuals of different genotypes? |
| i. | If the population is equally divided between males and females, what proportion of all matings will be between an AA male and an AA female? Between an AA male and an Aa female? Between an AA male and an aa female? |
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Students have asked these similar questions
I. A population called the founder generation, consisting of 2000 AA individuals, 2000 Aa individuals, and6000 aa individuals is established on a remote island.Mating within this population occurs at random, thethree genotypes are selectively neutral, and mutationsoccur at a negligible rate.a. What are the frequencies of alleles A and a in thefounder generation?b. Is the founder generation at Hardy-Weinbergequilibrium?c. What is the frequency of the A allele in the secondgeneration (that is, the generation subsequent to thefounder generation)?d. What are the frequencies for the AA, Aa, and aagenotypes in the second generation?e. Is the second generation at Hardy-Weinbergequilibrium?f. What are the frequencies for the AA, Aa, and aagenotypes in the third generation?
Which of the following statements is true about linkage disequilibrium?
a.
New alleles are born into a population in LE with the surrounding loci
b.
Genetic hitchhiking results from LD between surrounding loci and a locus under strong selection
c.
Loci in LE in two different populations with different allele frequencies will remain in LE when the two populations completely merge into a single population.
d.
The greater the selection on a locus, the smaller the haplotype block maintained around it
e.
D= 0.15 indicates that two loci are in greater LD than D= -0.23
Consider a sample of 100 individuals sampled from a population in Hardy-Weinberg
equilibrium that are genotyped at a single locus.
Of these 100 individuals, 25 individuals are A¡A1, 45 are A1A2, and 30 are A2A2.
What is the actual (observed) allele frequency of the A1 allele in this sample?
(you may use a calculator if needed)
O A. 0.325
O B. 0.275
O C. 0.475
O D. 0.525
Chapter 21 Solutions
Genetics: From Genes to Genomes
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