Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 2, Problem 34P
Interpretation Introduction
Interpretation:
The conformation of Pro-X peptide bonds needs to be compared with that of X-Pro peptide bonds.
Concept introduction:
Amino acids are compounds containing amino as well as acidic group. The general molecular structure of an amino acid is as follows:
Here, R is different group for different amino acids. If there is more than one amino group present in an amino acid, they are considered as basic amino acids and if there is more than one carboxylic group then they are considered as acidic amino acids.
Two or more amino acids combine to form di- or polypeptide chains. Here, peptide bond is the amide bond formed between the two amino acids.
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Students have asked these similar questions
the resonance stabilization of the amide linkage has profound
effects on protein structure. Which of the following are the direct effect(s) of this on
protein structure?
Select all that apply
All six atoms around the bond (including the Co) lie on the same plane
There is no free rotation about the peptide bond.
The bond between the carbon and the nitrogen in the peptide bond keeps
"flickering" between being a single bond and a double bond.
The peptide bond is polar.
The nitrogen in the peptide bond cannot accept a hydrogen bond.
The different types of
interactions that stabilize the
protein tertiary structure are
illustrated in the diagram below.
Which type of interaction moves
some part of the polypeptide
chain toward the inside of the
folded protein?
OH
Hydrophilic OH CH₂
interaction
with water
Hydrogen bond
-NH₂3-0- C
Salt
bridge
-CH₂-OH
C=0
H-N
H
0-CH,-
I
H
Hydrogen bond
Salt bridge
O Disulfide bond
222
-SIS
Hydrophobic
interaction
200
O Hydrogen bond
O Hydrophilic interaction
Disulfide
bonds
B-Pleated sheet
O Hydrophobic interaction
CH₂
CH₂
a Helix
CH3
CH3
Hydrogen bonds
What would the net charge be of a polypeptide with the
sequence M-D-R-N-Q-K-R-W at pH 8? hint ionizable groups
include N-terminus (pKa = 9.0), D (pKa = 3.9), R (pKa = 12.5), K
(pКa %3D 10.5)
O +2
O-1
O +1
Chapter 2 Solutions
Biochemistry
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 5PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10P
Ch. 2 - Prob. 11PCh. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 16PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 29PCh. 2 - Prob. 30PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37P
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