Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 2, Problem 23P
Interpretation Introduction
Interpretation:
The groups in a protein that can form hydrogen bonds or electrostatic bonds with an arginine side chain at pH 7, needs to be identified.
Concept introduction:
Amino acids are the building blocks of proteins and Protein plays a vital role in almost all biological processes. A huge proportion of our cells, tissue and muscles are made up of amino acids, means they carry out several significant bodily functions, like, providing cells their structure.
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Peptides.
1. Draw the peptide Ala-Glu-Gly-Lys, as it would occur at physiological pH = 7.4.
The R groups of Ala and Gly are not acidic or basic, therefore do not have a pka and the charge
on these R groups is therefore independent of pH. Glu is acidic and Lys is basic, therefore the
charge on these amino acids is pH dependent. The pKas are shown below.
pKa
N-term = 9.0
C-term = 3.5
Glu4.1
Lys = 10.5
2. Draw a circle around the peptide bonds.
3. Label the C-terminus and the N-terminus.
4. What is the overall charge on the peptide at pH 7.4?
. A nervous polecat. Pyrrolysine (Pyl, O) and Selenocysteine (Sec, U) are two uncommon amino acids.
Knowing that these amino acids exists, translate the following amino acid sequence into one – letter code: Thr
– Trp – Ile – Thr – Cys – His – Tyr – Leu – Ile – Thr – Thr – Ile – Glu – Phe – Glu – Arg – Arg – Glu – Thr – Ala
– Arg – Glu – Asn – Thr – Tyr – Pyl – Sec – Met – Ala – Leu – Phe – Pyl – Tyr.
7 Protein structure.Circle one of the three amino acid sequences that is most likely to
form a stable a-helix?
RASKTARQ
DASKTAEQ
KPGKPAGQ
In one sentence (that can be accompanied by a small picture) explain why?
Chapter 2 Solutions
Biochemistry
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 5PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10P
Ch. 2 - Prob. 11PCh. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 16PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 29PCh. 2 - Prob. 30PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37P
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Beta folding. Parallel and antiparallel beta folding sheets (be able to draw). Beta loops. Examples of proteins formed mainly by this structure.arrow_forwardSweet proteins. List the key classes of glycoproteins, their defining characteristics, and their biological functions.arrow_forwardBe sure to answer all parts. Give the amino acid sequence of an octapeptide that contains the amino acids Val, Met, Asp (2 equiv), Phe, Trp, Ile, Lys, and forms the following fragments when partially hydrolyzed with HCl: Ile-Asp-Phe, Lys-Met-Val-Trp, and Phe-Asp-Lys-Met. Trp Leu Phe Leu Val Lys Gly Tyr Xarrow_forward
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- Do not give handwriting solution. Draw A mixed triacylglycerol that contains one saturated 8 - carbon fatty acid chain and two 6 - carbonfatty acid chains with 2 trans double bonds each.arrow_forwardLong explanations are not needed. Answers and brief descriptions would be enough. During the formation of the peptide bond which of the following takes place? a. Hydrogen atom is lost from its carboxyl group of one amino acid and a hydrogen atom is lost from the amino group of another amino acid. b. Hydrogen atom is lost from its carboxyl group of one amino acid and a hydroxyl group is lost from the amino group of another amino acid. c. Hydroxyl group is lost from its carboxyl group of one amino acid and a hydroxyl group is lost from the amino group of another amino acid. d. Hydroxyl group is lost from its carboxyl group of one amino acid and a hydrogen atom is lost from the amino group of another amino acid.arrow_forwardThis is DNA. Locate the nitrogen bases (nitrogens are blue). Where are they located in the molecule?Locate the sugars and phosphates, and describe their location. Adjacent nucleotides are linked by covalent phosphodiester bonds (-O-P-O-) produced by a condensation reaction. What parts of the adjacent nucleotides are linked by phosphodiester bonds?Two nitrogenous bases extending towards the middle of the double helix. Are there any covalent bonds between these bases?If there are no covalent bonds between these bases, what other kinds of bonds might hold the two strands of the double helix together?arrow_forward
- Based. On the table explain the difference of net charge between 168.1 and the 168.10 molecular clones. Consider the initial net charge of the 168.1 clone and what ionizable amino acids contribute to such charge. Assume that histidine is neutral due to the pharrow_forwardLabel the horizontal axis. Consider two proteins: hexokinase has a pI ~ 4.5, and actin has a pI ~ 7.5. Draw a curve for each protein on the axes, indicating how the charge of the protein changes with the pH of the medium. Be sure to label which curve is which.arrow_forwardб. Draw all possible products of a single hydrolysis being completed on the following polypeptide: Ala-Ser-Met-Serarrow_forward
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Biomolecules - Protein - Amino acids; Author: Tutorials Point (India) Ltd.;https://www.youtube.com/watch?v=ySNVPDHJ0ek;License: Standard YouTube License, CC-BY