Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Question
Chapter 2, Problem 5P
Interpretation Introduction
Interpretation:
The following amino acids have R groups that have hydrogen-bonding potentials needs to be identified.
Ala, Gly, Ser, Phe, Glu, Tyr, Met, and Thr
Concept introduction:
Amino acids are organic compounds containing amino as well as
Here, R group is different for different amino acids. This group can be acidic, basic or neutral.
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the amino acid shown here us lysine. the
amino acud has three ionizable groups. use
structure and pka shown to draw and
calculate the charge of the amino acid at pH
1,7,9,12
pКа 2.18
H,N.
HO,
pКa 10.50
NH2
pka 8.50
Which of the following amino acids have R groups that have hydrogen- bonding potential? Ala, Gly, Ser, Phe, Glu, Tyr, Ile, and Thr
Shown below is the structure of a polypeptide with the pK, values of its acidic hydrogens.
pK =
= 10.1
H
OH pK, = 9.2
H.
pKa = 2.1 H.
N-H pK, = 6.0
pKa = 3.9
1. How many peptide bonds are present in one molecule of the polypeptide?
[ Select ]
II. Over what pH range would this molecule predominantly exist in a state that has a net charge of zero?
[ Select ]
ZI
Chapter 2 Solutions
Biochemistry
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 5PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10P
Ch. 2 - Prob. 11PCh. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 16PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 29PCh. 2 - Prob. 30PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37P
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- A polypeptide with a net positive charge at physiologic pH (~7.4) most likely contains amino acids with R groups of what type? Aliphatic R groups Basic R groups O Aromatic R groups O Acidic R groupsarrow_forwardWhich of the following shows the reaction by which valine and leucine form a peptide bond H. H. H O -COO H2N-C-C-NH- C- C-OH + HO CH2 CH,SH ČH3 А. C. CH(CH)2 H. HN-C-C-NH-C- C-OH H,N-CH-C- + H,O HC-C-H CH2 CH2 H CH3 CH H,C-C-H CH(CH3)2 CH В. D.arrow_forwardProteins are quite stable. The lifetime of a peptide bond in aqueous solution is nearly 1000 years. However, the free energy of hydrolysis of proteins is negative and quite large. How can you account for the stability of the peptide bond in light of the fact that hydrolysis releases much energy?arrow_forward
- Chemistry Draw the stable form of the peptide Ser-Trp-Glu-Asp-Cys-Asn at pH 10.40. Be sure to explicitly label every N, O, S as well as H that is not attached to carbon in the main chain and indicate a rectangle to identify the six atoms that are coplanar with the peptide bond between residue 2 and 3 in the peptidearrow_forwardNeed help The β chains of HbA and HbS were treated with trypsin, and the sequence of the N-terminal tryptic peptides are as given below. Do these peptides separate from each other in an electric field if the pH is 7.0? Explain in detail the reasoning behind your answer and include your calculations for the charge of each peptide in your answer. HbA: Val-His-Leu-Thr-Pro-Glu-Glu-Lys HbS: Val-His-Leu-Thrarrow_forwardThe tertiary structure of a protein is maintained by interactions between the side chains of amino acid residues one such interaction is between cysteine residues, sketch a covalent bond link that can form between side chains of two cysteine residues. Only relevant atoms that can form the link need to be shownarrow_forward
- Draw out the basic amino acid structure (not specific) What is a peptide bond?arrow_forwardA peptide bond... is a version of an ester bond is a version of an amide bond is the basis of protein secondary structure is formed by addition of waterarrow_forwardthe overall, net ionic charge on this peptide at pH = 7 would be: Cys - Ala - Glu-Arg - Met - Serarrow_forward
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