Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 18, Problem 32P
Summary Introduction
a.
To determine:
The difference in the mode of transmission of therapeutic genes delivery by retrovirus and AAV vectors.
Introduction:
Retroviral vectors are constructed by using RNA (Ribonucleic acid) containing retroviruses, whereas AAV vectors are made up of adeno-associated viruses.
Summary Introduction
b.
To determine:
The advantage and disadvantage of retroviral vectors and AAV vectors.
Introduction:
Vectors act as the carriers for the transfer or delivery of specific genes inside the genome of organisms. The mode of transmission varies with different types of vectors.
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discuss the benefits and limitations of using a retroviral system or an adenovirus for the delivery of a therapeutic gene.
Viruses:
a. Describe the structure and composition of viruses. What are three reasons that they are different from cellular organisms?
b. Describe what a lysogenic bacteriophage is and how it is different from a lytic bacteriophage.
c. Describe what is similar and different about the lifecycle of a non-enveloped DNA animal virus compared to an enveloped animal retrovirus.
Discuss the advantages and disadvantages of the use of the following viruses as vectors
a. Retroviruses b. Adenoviruses c. Adeno-associated viruses
Chapter 18 Solutions
Genetics: From Genes to Genomes
Ch. 18 - Match each of the terms in the left column to the...Ch. 18 - Mice are usually gray, but a mouse geneticist has...Ch. 18 - Sometimes, genes transferred into the mouse genome...Ch. 18 - In mice, a group of so-called Hox genes encode...Ch. 18 - The fly eyes shown in Fig. 18.7 are malformed...Ch. 18 - This problem concerns a technique called enhancer...Ch. 18 - Fish and other organisms that live in the Arctic...Ch. 18 - a. Describe two ways you could potentially make a...Ch. 18 - Figure 18.6 shows a picture of Glofish ,...Ch. 18 - Some people are concerned about the possible...
Ch. 18 - The goal of the Knockout Mouse Project is to...Ch. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - a. Which genome manipulation technique would you...Ch. 18 - a. Diagram a knockin construct that could have...Ch. 18 - Prob. 16PCh. 18 - Prob. 17PCh. 18 - The transcription factor Pax6 is required...Ch. 18 - Mouse models for human genetic diseases are...Ch. 18 - One way to determine where inside a cell a protein...Ch. 18 - In Problem 5 in Chapter 17, you saw that a SNP...Ch. 18 - Scientists now routinely use CRISPR/Cas9 to make...Ch. 18 - Geneticists are currently considering using...Ch. 18 - a. Figures 18.9 and 18.12 demonstrated methods to...Ch. 18 - Nonhomologous end-joining NHEJ of a double-strand...Ch. 18 - One problem that researchers sometimes encounter...Ch. 18 - Researchers at the University of California at San...Ch. 18 - Prob. 28PCh. 18 - F. Port and S. Bullock at the University of...Ch. 18 - On Fig 18.14, locate the PAM site and identify the...Ch. 18 - Prob. 31PCh. 18 - Prob. 32PCh. 18 - Recall that Leber congenital amaurosis LCA, a form...Ch. 18 - One potential strategy for gene therapy to correct...Ch. 18 - Recently, scientists have used a mouse model for...
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