Chapter 18, Problem 18.3PS

Frameshift Mutations. Each of the mutants listed below this paragraph has a different mutant form of the gene encoding protein X. Each mutant gene contains one or more nucleotide insertions (+) or deletions (−) of the type caused by acridine dyes. Assume that all the mutations are located very near the beginning of the gene for protein X. In each case, indicate with an “OK” if you would expect the mutant protein to be nearly normal or with a “Not OK” if you would expect it to be obviously abnormal.

(a) −

(b) −/+

(c) −/−

(d) +/−/+

(e) +/−/+/−

(f) +/+/+

(g) +/+/−/+

(h) −/−/+/−/−

(i) −/−/−/−/−/−