Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 17, Problem 42P
Figure 17.29 shows that the Sxl protein binds to the mRNA of the msl-2 gene, inhibiting translation of the mRNA’s proper reading frame. The MSL-2 protein is a transcription factor that binds to the X chromosome in 42.XY males to double the level of X-linked gene transcription, thus equalizing X-linked gene expression in XY males and XX females.
a. | In which sex, XY males or XX females, would the Sxl protein bind to the msl-2 mRNA? |
b. | As discussed in Problem 41, some Sxl alleles are lethal to females and others are lethal to males. Is the function of Sxl in regulating the synthesis of Msl-2 protein sufficient to explain the sex-specific lethality caused by both kinds of alleles? |
c. | Predict the effect of loss-of-function mutations in msl-2 on male and female fertility and viability. |
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In humans, dosage compensation is accomplished by:
inactivating one X chromosome in female somatic cells
inactivating one homolog from each homologous pair of chromosomes in female somatic cells
inactivating the Y chromosome in male somatic cells
increasing gene expression from the X chromosome in male somatic cell
Human females who are heterozygous for an X-linked recessive allele sometimes exhibit mild expression of the trait. However, such mild expression of X-linked traits in females who are heterozygous for Xlinked alleles is not seen in Drosophila. What might cause this difference in the expression of X-linked genes between human females and female Drosophila? (Hint: In Drosophila, dosage compensation is accomplished by doubling the activity of genes on the X chromosome of males.)
Imagine a scenario in which prenatal testing of a human female fetus indicates that the baby will have a normal XX karyotype but is heterozygous for a mutation that inactivates the Xist promoter. Allele “Xr” represents the mutated version of the Xist promoter, and “XR” represents the normal version of the Xist promoter.
How will this mutation affect the process of X inactivation?A. "X inactivation will still be random with both mutant and normal X chromosomes being randomly inactivated"
B. "The chromosome with the mutant Xist promoter will always be active"
C. "The chromosome with the mutant Xist promoter will always be inactivated"
D. "The normal X chromosome (no mutation in Xist) will always be active"
E. "The normal X chromosome (no mutation in Xist) will always be inactivated"
Chapter 17 Solutions
Genetics: From Genes to Genomes
Ch. 17 - For each of the terms in the left column, choose...Ch. 17 - For each of the following types of gene...Ch. 17 - List five events other than transcription...Ch. 17 - Which eukaryotic RNA polymerase RNA pol I, pol II,...Ch. 17 - As shown in the following diagram, a single...Ch. 17 - You have synthesized an enhancerless GFP reporter...Ch. 17 - Prob. 7PCh. 17 - Prob. 8PCh. 17 - A single UAS regulates the expression of three...Ch. 17 - MyoD is a transcriptional activator that turns on...
Ch. 17 - a. Assume that two transcription factors are...Ch. 17 - Prob. 12PCh. 17 - In Problem 12, you identified a genomic region...Ch. 17 - Prob. 14PCh. 17 - Prob. 15PCh. 17 - Genes in both prokaryotes and eukaryotes are...Ch. 17 - Prob. 17PCh. 17 - Lysine 4 of histone H3 H3K4 is methylated in the...Ch. 17 - J.T. Lis and collaborators have developed an...Ch. 17 - Hydatiform moles are growths of undifferentiated...Ch. 17 - Prader-Willi syndrome is caused by a mutation in...Ch. 17 - The human IGF2 gene is autosomal and maternally...Ch. 17 - Follow the expression of a paternally imprinted...Ch. 17 - Reciprocal crosses were performed using two inbred...Ch. 17 - Interestingly, imprinting can be tissue-specific....Ch. 17 - Prob. 26PCh. 17 - A method for detecting methylated CpGs involves...Ch. 17 - Honeybees Apis mellifera provide a striking...Ch. 17 - Consider the experiment in Fig. 17.24, where the...Ch. 17 - A protein or RNA that regulates gene expression in...Ch. 17 - a. How can a single eukaryotic gene give rise to...Ch. 17 - A hunchback gene, a gene necessary for proper...Ch. 17 - You know that the mRNA and protein produced by a...Ch. 17 - You are studying a transgenic mouse strain that...Ch. 17 - Prob. 35PCh. 17 - Scientists have exploited the siRNA pathway to...Ch. 17 - Persimmons Diospyros lotus are dioecious plants,...Ch. 17 - Drosophila females homozygous for loss-of-function...Ch. 17 - The text has discussed the RNA-Seq technique,...Ch. 17 - Researchers know that Fru-M controls male sexual...Ch. 17 - The Drosophila gene Sex lethal Sxl is deserving of...Ch. 17 - Figure 17.29 shows that the Sxl protein binds to...
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- Explain about how X chromosome inactivation takes place in mammals at the chromosomal and molecular level. B. What genes are involved in inactivating a human X chromosome? . C. What role does X chromosome-specific inactivating transcript --XIST-- non coding RNA play in the inactivation of the human X chromosome.arrow_forwardWhen the organization of adjacent genes with highly similar sequences is in an inverted orientation, this can reduce the expression of other genes that have similar sequence and are located on other chromosomes. Explain the mechanism of how this generally occurs.arrow_forwardDefine the Random Monoallelic Expression: Inactivation of the X Chromosome ?arrow_forward
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