Describe the molecular process of X-chromosome inactivation.This description should include the three phases of inactivationand the role of the Xic. Explain what happens to the X chromosomes during embryogenesis, in adult somatic cells, and duringoogenesis.

When the His− Salmonella strain used in the Ames testis exposed to substance X, no His+ revertants are seen.If, however, rat liver supernatant is added to the cellsalong with substance X, revertants do occur. Is substanceX a potential carcinogen for human cells? Explain

Which is a FALSE statement about X inactivation in mammalian females? O Females that are heterozygous for an X-linked gene have patches of cells that express one allele and patches of cells that express the other. O Xinactivation is random as to which X is inactivated and takes place early in embryonic development Inactivation is initiated by expression of the Xist gene on the X chromosome that will remain active. Once an X chromosome first becomes inactivated in a cell, that same X will remain inactivated in somatic cells that are descendants of this cell. DOOO

Occasionally, a mouse X chromosome is broken into two pieces and each piece becomes attached to a different autosome. A scientist studies this cell, and finds that the genes on only one of the two pieces undergo inactivation. By referring to the mechanism of X-chromosome inactivation, explain the observation made by the scientist.

What is the main lincRNA involved in X-inactivation, and what is known about its function?

Briefly describe the molecular processes that cause one X chromosome in each female cell to be active and the other X chromosome to be inactivated.

Explain about how X chromosome inactivation takes place in mammals at the chromosomal and molecular level.    B. What genes are involved in inactivating a human X chromosome?  . C. What role does  X chromosome-specific inactivating transcript --XIST-- non coding RNA play in the inactivation of the human X chromosome.

Explain this to me…..

Over a period of two years, a man in his early 20s receiveda series of intermittent chemotherapy and radiotherapytreatments for Hodgkin disease. During this therapy, heand his wife were unable to initiate a pregnancy. The man had aseries of his semen samples examined at a fertility clinic. The findings revealed that shortly after each treatment very few mature sperm were present, and abnormal chromosome numbers were often observed in developing spermatocytes. However, such chromosome abnormalities disappeared about 40 days after treatment, and normal sperm reappeared about 74 days posttreatment. How might a genetic counselor explain the time-related differences in sperm production and the appearance and subsequent disappearance of chromosomal abnormalities?

What are X-inactivation and Barr body?