Describe the molecular process of X-chromosome inactivation.This description should include the three phases of inactivationand the role of the Xic. Explain what happens to the X chromosomes during embryogenesis, in adult somatic cells, and duringoogenesis.
Q: Describe the "folded-fiber" model of the mitotic chromosome.
A: Folded fibre model This model of chromosome was proposed by DuPraw in 1965 through his studies on…
Q: Describe the process of X-chromosome inactivation in mammals
A: X-chromosome inactivation, also known as lyonization, is a process by which one of the copies of the…
Q: The Xg cell-surface antigen is coded for by a gene located on the X chromosome. No equivalent gene…
A: The individual with Klinefelter’s syndrome has 47 chromosomes in the diploid cells. The males show…
Q: describe the Chromosomal rearrangements caused by TEs
A: Transposable elements (TE) or transposons are segments of DNA that can move around the genome. It…
Q: Describe the mechanism of chromosome compaction
A: Answer:- The chromosomes contain the genetic material of the cell. It contains DNA in coiled form.…
Q: In the absence of SPO11, what meiotic events will be affected during early prophase I?
A: Spo11 protein encoded by gene Spo11 plays an important role in creating double-stranded breaks and…
Q: Outline the molecular steps in the process of X-chromosomeinactivation (XCI). Which step plays a key…
A: Euchromatin is defined as the active form of chromosomal DNA whereas heterochromatin is defined as…
Q: Occasionally, a mouse X chromosome is broken into two pieces and each piece becomes attached to a…
A: Introduction One Of Two Sex Chromosomes Is The X Chromosome. The X And Y Chromosomes Are Found In…
Q: Why is the gene for eye color in drosophila present on the X chromosome ?
A: Gene is the basic unit of heredity for all life forms. It is transferable from one generation to its…
Q: Explain the two major mechanisms by whichchromosomal rearrangements take place.
A: The breaking and reassembling of chromosomal segments accompanying evolution that can occur within…
Q: Define the Random Monoallelic Expression: Inactivation of the X Chromosome ?
A: They were discovered in 1876. These are the tertiary structures of DNA (deoxyribonucleic acid)…
Q: With regard to the numbers of sex chromosomes, explain whydosage compensation is necessary
A: Epigenetic inheritance is one of the examples of non-Mendelian inheritance pattern. It is an…
Q: Describe the folded-fiber model of the mitotic chromosome
A: Taylor and his coworkers introduced this model of chromosome structure in 1957, 1963 and is based on…
Q: Why is the development of individuals with Klinefelter's and Turner's syndromes relatively normal,…
A: This syndrome occur due to presence of an additional copy of X chromosomes resulting into karyotype…
Q: Explain the process of X-Chromosome Inactivation in Mammalian Females.
A: Mammals are the vertebrate having mammary glands as one of their main characteristics which…
Q: ngineer a chromosomally XY mouse in which SRY gene is inactivated. What do you expect to observe in…
A: The DNA molecule is bundled into chromosomes, which are thread-like structures found in the nucleus…
Q: In fruit flies, dosage compensation is achieved bya. X-chromosome inactivation.b. doubling the…
A: Dosage compensation refers to the mechanism of equalizing or balancing the expression of genes. It…
Q: how does X chromosome inactivation occur?
A: Female mammal's somatic cells contain two X chromosomes. Each of them is inherited from their…
Q: In X chromosome inactivation... A-Why it is inactivated? B- How it is inactivated? C-Is the…
A: Epigenetics is the subject of heritable differences in gene representation that do not require…
Q: With respect to X chromosome inactivation, which of the following statements are correct? OX…
A: X-chromosome inactivation happens at random in female cells during development for one of the two X…
Q: Following X-chromosome inactivation, most of the genes on theinactivated X chromosome are silenced.…
A: Females have two copies of the X chromosome, producing a double dose of X-linked genes. The…
Q: What is the spreading phase of X-chromosome inactivation? Whydo you think it is called a spreading…
A: Heterochromatization of one X chromosome begins in the late blastocyst stage of the embryonic life.…
Q: Explain about inactivated X chromosome in female mammalian cells ?
A: The sex of the offspring is generally genetically determined by the genes present on the sex…
Q: A cytogeneticist is studying the cells from an abnormal female monkey. In some cells, she finds that…
A: When a mammal embryo is developing, one of the chromosomes in each pair will randomly become…
Q: X inactivation explains the large color patches in calico cat fur and the smaller patches in…
A: The calico and tortoiseshell cats are named for their cat coloring. The cat genes are usually…
Q: Discuss the similarities and differences between X-chromosomeinactivation and genomic imprinting
A: X inactivation refers to the inactivation of all of the genes in one X chromosome in all the somatic…
Q: If X inactivation compensates for an extra X chromosome, why do Klinefeltermales (XXY) have problems…
A: DNA is considered to be the genetic material within the nucleus that gets packed in thread-like…
Q: Distinguish
A: Chromosomal abnormalities:-Almost every cell in our body contains 23 pairs of chromosomes, for a…
Q: Xist encodes a protein that will coat a Y chromosome to promote its compaction. Xist is located in…
A: Xist is a gene product which is inactive and it helps in dosage compensation in females. Females…
Q: Why do females not produce more protein encoded by genes on the X chromosome than males? One X…
A: The Y chromosome is one-third the size of the X chromosome and contains about 55 genes while the X…
Q: In X-chromosome inactivation, when is the choice made as to which X chromosome is inactivated? Does…
A: Females have two copies of the X chromosome, producing a double dose of X-linked genes. The…
Q: Outline the process of X-chromosome inactivation.
A: The X-chromosome contains approximately 1000 genes, which are necessary for the proper development…
Q: what is X-chromosome reactivation.?
A: The X chromosome is one of the sex chromosomes that is an essential chromosome for survival. The X…
Q: describe X-chromosome reactivation.
A: The X chromosome is one of the sex chromosomes that is an essential chromosome for survival. The X…
Q: If a cell is deficient of REC8, how would this affect the chromosome movement during mitosis and…
A: REC8 is a very important component of meiosis specifically the prophase It forms the pro phase…
Q: Discuss the types of experimental observations that Mary Lyonbrought together in proposing her…
A: A sex chromosome also termed as allosomes are involved in the determination of sex in individuals.…
Q: Explain the unique features of Ig genes.
A: Ig genes encode Immunoglobulins which provide protection to our body from Pathogens or foreign…
Q: How are the genes on the X chromosome regulated?
A: Males have just one copy of the X chromosome, whereas females have two copies. There is evolutionary…
Q: A cytogeneticist is studying the cells from an abnormal female monkey. In some cells, she finds that…
A: reason for bar body formation The reason for this is that, in each somatic cell of a normal female,…
Q: Chorionic villus sampling is a procedure to determine if there are any abnormalities in chromosome…
A: Chorionic villus sampling is also used for the same purpose. Chorion is basically a membrane that…
Q: The characteristic “X” shape of chromosomes is _____. a. a result of maximum compaction of the…
A: The X-shape is also not one chromosome: it's two. One of the two angled columns that make that “X”…
Q: Occasionally, a mouse X chromosome is broken into two pieces and each piece becomes attached to a…
A: The X chromosome is one of the two sex chromosomes in mammals, along with the Y chromosome. The X…
Q: A cytogeneticist is studying the cells from an abnormal female monkey. In some cells, she finds that…
A: In species with XY sex-determination, a Barr body or X-chromatin is an inactive X chromosome in a…
Q: During embryonic development, what event causes one of the twoX chromosomes to be remain active,…
A: Introduction: X chromosome inactivation is also referred to as Lyonization and is a process in which…
Q: Briefly describe the molecular processes that cause one X chromosome in each female cell to be…
A: Inheritance is the process of transmitting the traits from parent to offspring. Traits of an…
Q: Give the typical sex-chromosome complement found in the cells of people with Turner syndrome, with…
A: Chromosome complement refers to the entire set of chromosomes in the nucleus of a cell in a…
Q: X chromosome inactivation in a diploid XX female is not completely inactivated, explain?
A: Introduction X chromosome inactivation: it is also referred as Lyonization. In this there is…
Q: Explain Maternal effect mutants affecting AP axis patterning
A: The fruit fly Drosophila melanogaster is well suited to genetic screens because their phenotypes are…
Describe the molecular process of X-chromosome inactivation.
This description should include the three phases of inactivation
and the role of the Xic. Explain what happens to the X chromosomes during embryogenesis, in adult somatic cells, and during
oogenesis.
Step by step
Solved in 2 steps
- Outline the process of X-chromosome inactivation.In X-chromosome inactivation, when is the choice made as to which X chromosome is inactivated? Does this choice occur in embryonic cells, in adult somatic cells, or both?Briefly describe the molecular processes that cause one X chromosome in each female cell to be active and the other X chromosome to be inactivated.
- Name two ways in which loss of p53 function contributes to a malignant phenotype. Explain how benzo(a) pyrene can cause loss of p53 function. Hint: Loss of p53 function occurs in the majority of human tumors.describe X-chromosome reactivation.X chromosome inactivation in a diploid XX female is not completely inactivated, explain?
- Describe three types of genetic changes that commonly convert aproto-oncogene to an oncogene. Explain how the genetic changesare expected to alter the activity of the gene product.what is X-chromosome reactivation.?Discuss the types of experimental observations that Mary Lyonbrought together in proposing her hypothesis concerning X-chromosome inactivation. In your own words, explain how these observations were consistent with her hypothesis.
- "Changes to the p53 protein structure can be caused by differences in DNA and can affect protein function." Can you give detailed explanation why this is causation and not correlation? The explanation should be related with mutation, structure changes during protein synthesis, chemical property changes in amino acids, and functions of p53 protein.Acquired mutation in the p53 gene is the most common genetic alteration found in human cancer (> 50% of all cancers). A germline mutation in p53 is the causative lesion of Li- Fraumeni familial cancer syndrome. In many tumors, one p53 allele on chromosome 17p is deleted and the other is mutated. What type of protein is encoded by the p53 gene? (A) Caspase (B) DNA repair enzyme (C) Membrane cell adhesion molecule (D) Serine phosphatase (E) Telomerase (F) Transcription factor (G) Tyrosine kinaseIdentify two genetic mechanisms whereby proto-oncogenes can become overexpressed. Select the two mechanisms. Identify two genetic mechanisms whereby proto-oncogenes can become overexpressed.Select the two mechanisms. 1) alterations in chromatin structure 2) a gain-of-function alteration 3)modification of proto-oncogenes products 4)mutations that result in an abnormal protein product 5)mutations within gene-regulatory regions