Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 17, Problem 22P
The human IGF2 gene is autosomal and maternally imprinted. Copies of the gene received from the mother are not expressed, but copies received from the father are expressed. You have found two alleles of this gene that encode two different forms of the IGF2 protein distinguishable by gel electrophoresis. One allele encodes a 60K (Kilodalton) blood protein; the other allele encodes a 50K blood protein. In an analysis of blood proteins from a couple named Bill and Joan, you find only the 60K protein in Joan’s blood and only the 50K protein in Bill’s blood. You then look at their children: Jill is producing only the 50K protein, while Bill Jr. is producing only the 60K protein.
| a. | With these data alone, what can you say about the IGF2 genotype of Bill Sr. and Joan? |
| b. | Bill Jr. and a woman named Sara have two children, Pat and Tim. Pat produces only the 60K protein and Tim produces only the 50K protein. With the accumulated data, what can you now say about the genotypes of Joan and Bill Sr.? |
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The human IGF2 gene is autosomal and maternally imprinted. Copies of the gene received from the mother are not expressed, but copies received from the father are expressed. You have found two alleles of this gene that encode two different forms of the IGF2 protein distinguishable by gel electrophoresis. One allele encodes a 60K (Kilodalton) blood protein; the other allele encodes a 50K blood protein. In an analysis of blood proteins from a couple named Bill and Joan, you find only the 60K protein in Joan’s blood and only the 50K protein in Bill’s blood. You then look at their children: Jill is producing only the 50K protein, while Bill Jr. is producing only the 60K protein. a. Draw the possible pedigree. With these data alone, what can you say about the IGF2 genotype of Bill Sr. and Joan? b.Bill Jr. and a woman named Sara have two children, Pat and Tim. Pat produces only the 60K protein and Tim produces only the 50K protein. With the accumulated data, what can you now say about the…
In humans, dosage compensation is accomplished by:
inactivating one X chromosome in female somatic cells
inactivating one homolog from each homologous pair of chromosomes in female somatic cells
inactivating the Y chromosome in male somatic cells
increasing gene expression from the X chromosome in male somatic cell
An experimental assay for the blood-clotting protein called factorIX is available. A blood sample was obtained from each individual in the following pedigree. The amount of factor IX protein, shown within each symbol on the pedigree, is expressed as a percentage of the average amount observed in individuals who do not carry a mutant copy of the gene.
Chapter 17 Solutions
Genetics: From Genes to Genomes
Ch. 17 - For each of the terms in the left column, choose...Ch. 17 - For each of the following types of gene...Ch. 17 - List five events other than transcription...Ch. 17 - Which eukaryotic RNA polymerase RNA pol I, pol II,...Ch. 17 - As shown in the following diagram, a single...Ch. 17 - You have synthesized an enhancerless GFP reporter...Ch. 17 - Prob. 7PCh. 17 - Prob. 8PCh. 17 - A single UAS regulates the expression of three...Ch. 17 - MyoD is a transcriptional activator that turns on...
Ch. 17 - a. Assume that two transcription factors are...Ch. 17 - Prob. 12PCh. 17 - In Problem 12, you identified a genomic region...Ch. 17 - Prob. 14PCh. 17 - Prob. 15PCh. 17 - Genes in both prokaryotes and eukaryotes are...Ch. 17 - Prob. 17PCh. 17 - Lysine 4 of histone H3 H3K4 is methylated in the...Ch. 17 - J.T. Lis and collaborators have developed an...Ch. 17 - Hydatiform moles are growths of undifferentiated...Ch. 17 - Prader-Willi syndrome is caused by a mutation in...Ch. 17 - The human IGF2 gene is autosomal and maternally...Ch. 17 - Follow the expression of a paternally imprinted...Ch. 17 - Reciprocal crosses were performed using two inbred...Ch. 17 - Interestingly, imprinting can be tissue-specific....Ch. 17 - Prob. 26PCh. 17 - A method for detecting methylated CpGs involves...Ch. 17 - Honeybees Apis mellifera provide a striking...Ch. 17 - Consider the experiment in Fig. 17.24, where the...Ch. 17 - A protein or RNA that regulates gene expression in...Ch. 17 - a. How can a single eukaryotic gene give rise to...Ch. 17 - A hunchback gene, a gene necessary for proper...Ch. 17 - You know that the mRNA and protein produced by a...Ch. 17 - You are studying a transgenic mouse strain that...Ch. 17 - Prob. 35PCh. 17 - Scientists have exploited the siRNA pathway to...Ch. 17 - Persimmons Diospyros lotus are dioecious plants,...Ch. 17 - Drosophila females homozygous for loss-of-function...Ch. 17 - The text has discussed the RNA-Seq technique,...Ch. 17 - Researchers know that Fru-M controls male sexual...Ch. 17 - The Drosophila gene Sex lethal Sxl is deserving of...Ch. 17 - Figure 17.29 shows that the Sxl protein binds to...
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