Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 17, Problem 3P
Interpretation Introduction
Interpretation: The result of the complete oxidation of 1 molecule of acetyl CoA in the citric acid cycle needs to be determined.
Concept Introduction:
Pyruvate formed by glycolysis is converted into acetyl CoA. Acetyl CoA acts as a fuel in the Krebs cycle. The citric acid cycle is a catabolic process. It is also known as the TCA cycle or Krebs cycle. It is a series of
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Long explanations are NOT NEEDED.
ATP accounting.
Consider 1 molecule of the sucrose (monomeric units: glucose and fructose) that will undergo complete oxidation.
a. Number of pyruvate molecules after glycolysis.b. Net ATP produced in glycolysis only (via substrate-level phosphorylation).c. Number of NADH produced using the pyruvate dehydrogenase complex reaction.d. Number of NADH and FADH2 produced from Krebs cycle.e. Net ATP produced (complete oxidation via Malate aspartate shuttle).
Long explanations are NOT NEEDED.
ATP accounting.
Consider 1 molecule of the sucrose (monomeric units: glucose and fructose) that will undergo complete oxidation.
d. Number of NADH and FADH2 produced from Krebs cycle.e. Net ATP produced (complete oxidation via Malate aspartate shuttle).
Butch Cassidy and the Sundance Kid. Glutamate dehydrogenase
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Chapter 17 Solutions
Biochemistry
Ch. 17 - Prob. 1PCh. 17 - Prob. 2PCh. 17 - Prob. 3PCh. 17 - Prob. 4PCh. 17 - Prob. 5PCh. 17 - Prob. 6PCh. 17 - Prob. 7PCh. 17 - Prob. 8PCh. 17 - Prob. 9PCh. 17 - Prob. 10P
Ch. 17 - Prob. 11PCh. 17 - Prob. 12PCh. 17 - Prob. 13PCh. 17 - Prob. 14PCh. 17 - Prob. 15PCh. 17 - Prob. 16PCh. 17 - Prob. 17PCh. 17 - Prob. 18PCh. 17 - Prob. 19PCh. 17 - Prob. 20PCh. 17 - Prob. 21PCh. 17 - Prob. 22PCh. 17 - Prob. 23PCh. 17 - Prob. 24PCh. 17 - Prob. 25PCh. 17 - Prob. 26PCh. 17 - Prob. 27PCh. 17 - Prob. 28PCh. 17 - Prob. 29PCh. 17 - Prob. 30PCh. 17 - Prob. 31PCh. 17 - Prob. 32PCh. 17 - Prob. 33PCh. 17 - Prob. 34PCh. 17 - Prob. 35PCh. 17 - Prob. 36PCh. 17 - Prob. 37PCh. 17 - Prob. 38PCh. 17 - Prob. 39PCh. 17 - Prob. 40PCh. 17 - Prob. 41PCh. 17 - Prob. 42PCh. 17 - Prob. 43PCh. 17 - Prob. 44P
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- Understanding the Oxidation of Glucose and Its Products in the TCA Cycle Glycolysis, the pyruvate dehydrogenase reaction, and the TCA cycle result in complete oxidation of a molecule of glucose to CO2. Review the calculation of oxidation numbers for individual atoms in any molecule, and then calculate the oxidation numbers of the carbons of glucose, pyruvate, the acetyl carbons of acetyl-CoA. and the metabolites of the TCA cycle to convince yourself that complete oxidation of glucose involves removal of 24 electrons and that each acetyl-CoA through the TCA cycle gives up 8 electrons.arrow_forwardLong explanations are not needed. True or Falsea. One NADH is produced for every pyruvate molecule undergoing oxidation using the enzyme pyruvate dehydrogenase complex b. Erythrose-4-phosphate can be synthesized using the pentose phosphate pathway.arrow_forward. Describe the reaction steps of the citric acid cycle with a focus on their control. In addition discuss the energy provided to a living cell from the metabolism of one acetyl-CoA entering the citric acid cyclearrow_forward
- I. ATP Calculation A. Given that three molecules of glucose underwent full oxidation, how many of the following is produced in each phase? Show your solutions. Glycolysis NADH FADH₂ ATP A B C Pyruvate Oxidation D E F G H I Kreb's Cyclearrow_forwardWorksheet on Computation of ATP yield from Fatty acid metabolism. Consider docosanoic acid, C21H43CO2H a. Label alpha (a) and beta ( B) carbons b. Draw the acyl COA derived from this fatty acid c. How many acetyl CoA molecules are formed by complete B-oxidation? d. How many cycles of B- oxidation are needed for complete oxidation? e. How many molecules of ATP are formed from the complex catabolism of this fatty acid.arrow_forwardHelp fill in the blanks Extended fasting will activate the processes of [glycolysis/gluconeogenesis] and [fatty acid synthesis/b-oxidation]. These processes will work to deplete [oxaloacetate/acetyl-CoA] and increase [oxaloacetate/acetyl-CoA]. As a result, flux through the citric acid cycle will [increase/decrease]. Ketone bodies will be produced in this state allowing for [NAD+/CoA/glucose] to be recycled. Ketosis also occurs in people on a [carb-rich/carb-poor] diet for similar reasons. Bafflingly at first, hyperglycemia in diabetics may also cause ketosis. The problem is not in the bloodstream in these patients, but in the hormones. Without insulin, [GLUT1/ GLUT2/GLUT4] will not appear on muscle cell membranes to clear glucose, and liver cells continue to receive signals from glucagon. Glucagon will [activate/inhibit] pathways that catabolize carbohydrate and [activate/inhibit] pathways that catabolize fatty acids to preserve the carbohydrate fuel of choice for the…arrow_forward
- Considering the complete oxidation of an 18-C fatty acid. Give the answer to the following question.a. What is the total number of NADH produced in TCA if all of the acetyl CoA enters the cycle? b. What is the total number of FADH2 produced in TCA if all the acetyl CoA enters the cycle?c. How much ATP is produced in the overall oxidation?arrow_forward. In deciding which form of isocitrate dehydrogenase plays the more important role in the citric acid cycle-the NAD*-dependent or the NADP*-dependent form-what kinds of information would help you?arrow_forwardG. ENZYME CLASSIFICATION. Identify the main class of enzymes used to catalyzed the following reactions: 1. Lactate dehydrogenase: NADH+H NAD HC-OH CH3 CH Pynnte Lactate 2. Methylmalonyl-CoA mutase: CH CH SCOA CH,CH, SCOA coenzyme B12 COO COO methylmalonyl-CoA succinyl-CoA 3. Enolase: 0. H–Ċ–0–P–0- C-0–P-0- + H,0 HO–CH, CH 6 Phosphoenolpyruvate 2-Phosphoglycerate 4. Chymotrypsin: -0–CH,CH3 + H2O - RCOOH + HOCH,CH3 5. Pyruvate carboxylase: coo • co, • ATP + H,0 H-C-H . ADP + P, + 2H čoo CH, Pyruvate Oxaleacetatearrow_forward
- Following glycolysis. Most of the energy from the original glucose is in the form of: A. CO2 B. H2O C. ATP D. pyruvic or lactic acid E. high-energy electrons that are associated with electron carriers.arrow_forwardAmong the choices,I. alpha-ketoglutarateII. GlutamineIII. NADPHIV. H+which among here is the intermediate of citric acid cycle wherein it undergoes reductive amination with glutamine and functions as nitrogen donorarrow_forwardDo you need pyruvate dehydrogenase for oxidation of citrate to CO2 ? No, Yes? Please explain why. don't. copy from internet.i will get to knowarrow_forward
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