Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 17, Problem 10P
Interpretation Introduction

Interpretation:

The purpose of the remaining steps in the pyruvate dehydrogenase reaction cycle other than the formation of acetyl Co A.

Concept introduction:

Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It helps in the conversion of pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

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Long explanations are NOT NEEDED. ATP accounting. Consider 1 molecule of the sucrose (monomeric units: glucose and fructose) that will undergo complete oxidation. a. Number of pyruvate molecules after glycolysis.b. Net ATP produced in glycolysis only (via substrate-level phosphorylation).c. Number of NADH produced using the pyruvate dehydrogenase complex reaction.d. Number of NADH and FADH2 produced from Krebs cycle.e. Net ATP produced (complete oxidation via Malate aspartate shuttle).
True or false: F1 unit of ATP synthase is capable of synthesizing 3ATP molecules per a complete revolution. F1 unit can synthesize 4 or 5ATP molecules if the c subunit of F0 unit has more than 12 proton binding peptides.  Unlike Complex I inhibitors, Complex IV inhibitors can shut down the entire ETC.
True or False? Intermediates in the glycolysis pathway can be a source of raw material if the cell wants to construct biological molecules such as triglycerides or amino acids, but the citric acid cycle cannot be used this way.
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