Human Physiology
15th Edition
ISBN: 9781259864629
Author: Fox, Stuart Ira
Publisher: Mcgraw-hill Education,
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Chapter 17, Problem 23RA
Summary Introduction
To review:
1. The structure of the epithelial wall of the proximal convoluted tubule (PCT).
2. The role of distribution of Na+/K+ pumps of the membrane in reabsorption of salts and water.
Introduction:
Kidneys are a major part of the excretory system that regulates the filtration of blood and removes the waste products. The kidney has two main parts, namely the renal cortex that is the external part and the renal medulla, which is the internal part of the kidney. The nephron is the structural and functional unit of the kidneys.
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Students have asked these similar questions
In the proximal tubule, the reabsorption of Na+, amino acids, and glucose causes
(before water moves):
Decreased osmolarity of the tubular fluid but increased osmolarity of the
interstitial fluid
Decreased osmolarity of the tubular fluid and interstitial fluid
O Increased osmolarity of the tubular fluid but decreased osmolarity of the
interstitial fluid
O Increased osmolarity of the tubular fluid and the interstitial fluid
No changes in osmolarity
Differentiate transport maxima and gradient-time limited transport in proximal tubule.
All of the following are true about glucose recovery from the tubule fluid, except (choose the incorrect statement):
A. All filtered glucose is released in the PCT unless plasma glucose abnormally high
B. It is reabsorbed by coupling with Na+ recovery via a sodium glucose cotransporter
C. Glucose recovery is made possible by low intracellular Na+ concentrations created by the NaK pump
D. The CD recovers any glucose that is not reabsorbed by the PCT nephron loop and DCT
this is not and will not be graded
Chapter 17 Solutions
Human Physiology
Ch. 17 - Describe the "theme" of kidney function in a...Ch. 17 - Draw and label the tubular components of a nephron...Ch. 17 - Trace the course of tubular fluid from the...Ch. 17 - Trace the course of blood flow through the kidney...Ch. 17 - Describe the structures that plasma fluid must...Ch. 17 - Describe the forces that affect the formation of...Ch. 17 - Explain the significance of the glomerular...Ch. 17 - Prob. 5bCPCh. 17 - Describe the mechanisms for salt and water...Ch. 17 - Compare the transport of and water across the...
Ch. 17 - Describe the interaction between the ascending and...Ch. 17 - Explain how ADH helps the body conserve water. How...Ch. 17 - Define renal plasma clearance and describe how...Ch. 17 - Define the terms reabsorption and secretion. Using...Ch. 17 - Explain why the total renal blood flow can be...Ch. 17 - Define transport maximum and renal plasma...Ch. 17 - Describe the effects of aldosterone on the renal...Ch. 17 - Prob. 11bCPCh. 17 - Explain the mechanisms by which the cortical...Ch. 17 - Explain how the kidneys reabsorb filtered...Ch. 17 - Suppose a person with diabetes mellitus had an...Ch. 17 - List the different categories of clinical...Ch. 17 - Explain why most diuretics can cause excessive...Ch. 17 - Define uremia and discuss the dangers associated...Ch. 17 - Which of these statements about the renal pyramids...Ch. 17 - Match the following items:
Active transport of...Ch. 17 - Match the following items:
Active transport of...Ch. 17 - Match the following items:
Passively permeable to...Ch. 17 - Match the following items:
Passively permeable to...Ch. 17 - Antidiuretic hormone promotes the retention of...Ch. 17 - Aldosterone stimulates sodium reabsorption and...Ch. 17 - Substance X has a clearance greater than zero but...Ch. 17 - Prob. 9RACh. 17 - About of the glomerular ultrafiltrate is...Ch. 17 - Diuretic drugs that act in the nephron loop...Ch. 17 - The appearance of glucose in the urine a. occurs...Ch. 17 - Reabsorption of water through the tubules occurs...Ch. 17 - Which of these factors oppose(s) filtration from...Ch. 17 - The countercurrent exchange in the vasa recta...Ch. 17 - The kidneys help to maintain acid-base balance...Ch. 17 - Scientists currently believe that the main barrier...Ch. 17 - A drug that blocks the action of the organic anion...Ch. 17 - Explain how glomerular ultra filtrate is produced...Ch. 17 - Describe the transport properties of the nephron...Ch. 17 - Prob. 21RACh. 17 - Prob. 22RACh. 17 - Prob. 23RACh. 17 - Prob. 24RACh. 17 - Identify where secretion occurs in the nephron,...Ch. 17 - Which diuretic drugs do not produce hypokalemia?...Ch. 17 - Prob. 27RACh. 17 - Prob. 28RACh. 17 - Prob. 29RACh. 17 - Prob. 30RACh. 17 - Prob. 31RACh. 17 - Prob. 32RACh. 17 - s Suppose a woman with a family history of...Ch. 17 - Prob. 34RACh. 17 - Prob. 35RACh. 17 - Prob. 36RACh. 17 - Prob. 37RACh. 17 - Prob. 38RACh. 17 - Prob. 39RACh. 17 - Prob. 40RACh. 17 - Prob. 41RACh. 17 - Prob. 42RA
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- As the text noted, two-thirds of the water and solutes that the body reclaims by reabsorption in nephrons occurs in the proximal tubule. Proximal tubule cells have large numbers of mitochondria and demand a great deal of oxygen. Explain why.arrow_forwardExplain how the kidneys help to maintain the balance of acids and bases in extracellular fluid.arrow_forwardWhy is excretion important in order to achieve osmotic balance?arrow_forward
- Correlate transport maxima and gradient-time limited transport in proximal tubule.arrow_forwardThe process of hydrogen ion secretion in the proximal convoluted tubule occurs via which of the following mechanisms? Choose from the following: (A) hydrogen ions diffuse out of the glomerular filtrate of the proximal convoluted tubule, through extracellular fluid and into the peritubular blood (B) carbon dioxide diffuses into the proximal convoluted tubule cell from peritubular capillary blood; undergoes a chemical reaction to form carbonic acid; dissociates into hydrogen and bicarbonate ions; the hydrogen ion diffuses into the glomerular filtrate of the proximal convoluted tubule (C) hydrogen ions diffuse out of the peritubular capillary blood, through extracellular fluid and into the filtrate of the proximal convoluted tubule (D) carbon dioxide diffuses into the proximal convoluted tubule cell from the glomerular filtrate; undergoes a chemical reacdtion to form carbonic acid; dissociates into hydrogen and bicarbonate ions; the hydrogen ions diffuse into the peritubular bloodarrow_forwardIn response to hemorrhagic shock, the kidneys produce a small volumeof very concentrated urine. Explain how the rate of filtrate formationchanges and how Na+ transport is altered in the distal convoluted tubulein response to hemorrhagic shock.arrow_forward
- Diagram/flow chart the reactions and interactions of the renin-angiotensin-aldosterone pathway. What conditiion is the primary stimulus for its activation? What would hapen to renin secretion in a patient with chronic kidney failure?arrow_forwardWhich of the following contribute to the >99% glucose absorption in the proximal tubule?a. Cellular absorption and paracellular secretion of sodiumb. Paracellular absorption of glucose against a concentration gradientc. Basolateral membrane transport of glucose against a concentration gradientd. Basolateral diffusion of glucose through the lipid bilayerarrow_forwardConsidering the distal convoluted tubule of the amphibiannephron, explain how changes in the permeability of the tubulewall to water affect the amount of pure, osmotically free waterexcreted in the urine. Define what is meant by pure, osmoticallyfree water.arrow_forward
- Drugs that increase urine flow (diuretic drugs) are often employed in the treatment of hypertension (high blood pressure) or other disease states. Three physiological categories of such drugs are ones that (i) function as loop diuretics, (ii) inhibit the action of aldosterone, and (iii) block Na+ channels in the collecting ducts. Explain why each of these categories would be expected to increase Na+ excretion and urine flow.arrow_forwardRenin is secreted in response to hypovolemia or to an increase in the osmolality of the blood. Provide three possible mechanisms by which these conditions may stimulate rennin secretion. What are the consequences of increased rennin secretion that lead to increased aldosterone secretion? Present this sequence of events. Why are angiotensin converting enzyme inhibitors (ACEIs) used as a common therapy for hypertension? How do they influence blood pressure? Are plasma levels of renin elevated or depressed in a patient with Conn’s disease? Why?arrow_forwardSodium ion reabsorption from the filtrate into peritubular blood across the cells of this component of the nephron (marked by the black asterisk) Choose from the following: (A) is regulated by the binding of the hormone aldosterone (B) is not regulated by any hormone, but is determined by sodium ion concentration and filtrate flowarrow_forward
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