Drugs that increase urine flow (diuretic drugs) are often employed in the treatment of hypertension (high blood pressure) or other disease states. Three physiological categories of such drugs are ones that (i) function as loop diuretics, (ii) inhibit the action of aldosterone, and (iii) block Na+ channels in the collecting ducts. Explain why each of these categories would be expected to increase Na+ excretion and urine flow.

Drugs that increase urine flow (diuretic drugs) are often employed in the treatment of hypertension (high blood pressure) or other disease states. Three physiological categories of such drugs are ones that (i) function as loop diuretics, (ii) inhibit the action of aldosterone, and (iii) block Na+ channels in the collecting ducts. Explain why each of these categories would be expected to increase Na+ excretion and urine flow.

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter14: The Urinary System

Section: Chapter Questions

Problem 14RE

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Drugs that increase urine flow (diuretic drugs) are oftenemployed in the treatment of hypertension (high blood pressure)or other disease states. Three physiological categories of suchdrugs are ones that (i) function as loop diuretics, (ii) inhibitthe action of aldosterone, and (iii) block Na+ channels in thecollecting ducts. Explain why each of these categories wouldbe expected to increase Na+ excretion and urine flow. (Hint:Rereading the section on hormones at the end of Chapter 28might prove helpful.)
Indicate which of the following is (are) being described: angiotensisn II, aldosterone and/or ADH increases blood pressure by direct vasoconstriction (2 answers) stimulates insertion of aquaporins into the collecting duct (1) increases the secretion of the other two (1) acts on the principal cells of the nephron (2 answers) increases Na+ reabsorption by the kidney (1) has its production directly blocked by ACE inhibitors (1) increases water reabsorption by acting on kidney collecting duct (1)
During the maximal water diuresis, the ratio of the tubular fluid to plasma osmolarity is greater than 1.0 in which of the following? (A) The bend of the loop of Henle (B). Bowman Space (C) The collecting duct (D) The distal renal tubule (E) The proximal convoluted renal tubule