To give the explanation for aminolysis reaction of propionyl chloride and methylamine when one and two equivalents of methylamine is used. Concept introduction: Amine and acid chloride reacts to produce amide. In this reaction ofAcid chlorides and amine, a proton is also produced which protonates the unreacted amines . The protonated amine loses its nucleophilic property, as a result, it can’t react with acid chloride. To ensure the formation of amide we required twice the number of moles amine as the number of the acid chloride.

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Chapter 16, Problem 63P

Interpretation Introduction

Interpretation:

To give the explanation for aminolysis reaction of propionyl chloride and methylamine when one and two equivalents of methylamine is used.

Concept introduction:

Amine and acid chloride reacts to produce amide. In this reaction ofAcid chlorides and amine, a proton is also produced which protonates the unreacted amines. The protonated amine loses its nucleophilic property, as a result, it can’t react with acid chloride. To ensure the formation of amide we required twice the number of moles amine as the number of the acid chloride.

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