Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 13.3, Problem 1R
Summary Introduction
To review:
Meselson-Stahl experiment differentiating between three models of
Introduction:
Meselson-Stahl experiment was proposed by two scientists called Matthew Meselson and Franklin Stahl. In 1958, they supported Watson and Crick experiment which stated replication of genetic material called DNA (deoxyribonucleic acid) is semiconservative.
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What is meant by semi conservative replication? How did Meselson and Stahl prove it experimentally?
What did the Watson–Crick model suggest about the replication of DNA?
Why were Meselson and Stahl unable to distinguish between the dispersive and the semiconservative models following only one round of DNA replication?
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Life: The Science of Biology
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- Who experimentally prove that DNA replication is semi conservative?arrow_forwardIn the Meselson–Stahl experiment, which of the three modes of replication could be ruled out after one round of replication? after two rounds?arrow_forwardIf DNA replication followed the dispersive model of replication, how would the outcomes of the Meselson-Stahl experiment change? Describe the composition of DNA samples after one and two rounds of replication, and how this is different from the findings of the original experiment.arrow_forward
- How does the process of DNA replication generate mismatch mutations? What mechanisms are available to fix these errors during the process of replication?arrow_forwardIs it biologically possible for DNA to undergo replication in vivo, without the lagging and the leading strands? In PCR, we also start with an antiparallel strand of DNA. Does this also mean that replication is semi-discontinuous in in vitro replication?arrow_forwardDescribe the Meselon -Stahl experiment Include how they distinguished new from old DNA strands, what the centrifuge was for, and how it showed semi-conservative replication.arrow_forward
- What is one enzyme that is involved with DNA replication and how would the absence of this enzyme affect replication of both prokaryotic and eukaryotic DNA?arrow_forwardWhat would Meselson and Stahl have seen after 1,2, and 3 generations of replication if the dispersive model of DNA replication were correct?arrow_forwardIn the Meselson and Stahl experiment, what part of the DNA gets labeled with 15N? Why?arrow_forward
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