Concepts of Genetics (12th Edition)
Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 13, Problem 30ESP

The genetic code is degenerate. Amino acids are encoded by either 1, 2, 3,4, or 6 triplet codons (see Figure 13.7). An interesting question is whether the number of triplet codes for a given amino acid is in any way correlated with the frequency with which that amino acid appears in proteins. That is, is the genetic code optimized for its intended use? Some approximations of the frequency of appearance of nine amino acids in proteins in E. coli are given in the following:

Chapter 13, Problem 30ESP, The genetic code is degenerate. Amino acids are encoded by either 1, 2, 3,4, or 6 triplet codons

  1. (a) Determine how many triplets encode each amino acid.
  2. (b) Devise a way to graphically compare the two sets of information (data).
  3. (c) Analyze your data to determine what, if any, correlations can be drawn between the relative frequency of amino acids making up proteins and the number of codons for each. Write a paragraph that states your specific and general conclusions.
  4. (d) How would you proceed with your analysis if you wanted to pursue this problem further?
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In HbS, the human hemoglobin found in individuals with sickle-cell anemia, glutamic acid at position 6 in the beta chain is replaced by valine. Q.) Show that one of the glutamic acid codons can be converted to a valine codon by a single substitution mutation (i.e., by changing one letter in one codon).
The genetic information contained in DNA consists of a linear sequence of coding units known as codons. Each codon consists of three adjacent DNA nucleotides that corresponto a single amino acid in a protien.  The E.coli DNA molecule contains 4.70 x 10^6 base pairs. Determine the number of codons that can be present.  Assuming that the average protein in E.coli consists of a chain of 400 amino acids, calculate the maximum number of protiens that can be coded by an E.coli DNA molecule.

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Concepts of Genetics (12th Edition)

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