Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 13, Problem 18PDQ
Shown in the following table are several amino acid substitutions in the α and β chains of human hemoglobin. Use the genetic code table in Figure 12–7 to determine how many of them can occur as a result of a single
| Hb Type | Normal Amino Acid | Substituted Amino Acid |
| HbJ Toronto | Ala | Asp (α-5) |
| HbJ Oxford | Gly | Asp (α-15) |
| Hb Mexico | Gln | Glu (α-54) |
| Hb Bethesda | Tyr | His (β-145) |
| Hb Sydney | Val | Ala (β-67) |
| HbM Saskatoon | His | Tyr (β-63) |
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Which of the following mutations would most likely keep the transitions of T state to R state in hemoglobin unchanged, or similar to the
transitions that occur in the native molecule? The three-letter codes for amino acids are used, and the numbers following the amino
acids designate the amino acid position in the protein. By convention, the original, native amino acid is listed fırst, followed by the
mutational change.
Choose one:
O A. Asp94→Ile94
O B. Tyr42→Phe42
O C. Asp94 Glu94
O D. Tyr42-Gly42
Which amino acid pair constitutes the hydrophobic patch on sickle cell
hemoglobin that results in formation of protein oligomers with the Glu 6 -->
Val 6 sickle cell mutation? Does normal hemoglobin contain this same amino
acid pair constituting a hydrophobic patch?
Phe 85 / Leu 88; no
Phe 85 / Leu 88; yes
Trp 85 / Leu 88; yes
Olle 85 / Leu 88; yes
Pro 85 / Lys 88; no
Sickle cell anemia is caused by a point mutation in the β-globin chain of hemoglobin. Glutamic acid is replaced by Valine.
HBB sequence in normal adult hemoglobin (Hb A): Leu-Thr-Pro-Glu-Glu-Lys-Ser
HBB sequence in mutant adult hemoglobin (Hb S): Leu-Thr-Pro-Val-Glu-Lys-Ser
What effect does this mutation have on the structure and function of the protein?
Predict what would happen to the RBC if the glutamic acid was replaced with asparagine instead of valine.
Chapter 13 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. 13 - CASE STUDY | Crippled ribosomes Diamond Blackfan...Ch. 13 - CASE STUDY | Crippled ribosomes Diamond Blackfan...Ch. 13 - Prob. 3CSCh. 13 -
HOW DO WE KNOW?
1. In this chapter, we focused on...Ch. 13 - Review the Chapter Concepts list on p. 238. These...Ch. 13 - List and describe the role of all molecular...Ch. 13 - Contrast the roles of tRNA and mRNA during...Ch. 13 - Francis Crick proposed the adaptor hypothesis for...Ch. 13 -
6. During translation, what molecule bears the...Ch. 13 - Summarize the steps involved in charging tRNAs...
Ch. 13 - Each transfer RNA requires at least four specific...Ch. 13 -
9. Explain why the one-gene:one-enzyme hypothesis...Ch. 13 - Prob. 10PDQCh. 13 - Prob. 11PDQCh. 13 - Prob. 12PDQCh. 13 - Assuming that each nucleotide is 0.34 nm long in...Ch. 13 - Review the concept of colinearity in Section 12.5...Ch. 13 -
15. In your opinion, which of the four levels of...Ch. 13 -
16. List and describe the function of as many...Ch. 13 - How does an enzyme function? Why are enzymes...Ch. 13 -
18. Shown in the following table are several...Ch. 13 -
19. Three independently assorting genes are known...Ch. 13 -
20. How would the results in cross (a) of Problem...Ch. 13 - A series of mutations in the bacterium Salmonella...Ch. 13 -
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