Study Guide for Campbell Biology
11th Edition
ISBN: 9780134443775
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece, Martha R. Taylor, Michael A. Pollock
Publisher: PEARSON
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Chapter 12, Problem 10TYK
Summary Introduction
Introduction: Cell division results in two daughter cells from a single parent cell. There are many phases of the cell cycle. Cell cycle is divided into interphase and mitotic phase. Interphase is divided into gap1 (G1) phase, synthetic phase (S-phase), and gap 2 (G2) phase.
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Students have asked these similar questions
Which of the following statements about the cell cycle is TRUE?
a. The protein APC blocks cells from entering anaphase
b. CDKs are degraded after each cell cycle phase by the addition of a ubiquitin chain to the proteins
c. A kinase is a protein that adds a ubiquitin chain to other proteins Cyclin activity is necessary, but not always sufficient, for CDK activation
d. Cyclin proteins must be degraded before Cdk proteins can be activated
Cyclins and cyclin-dependent kinases regulate progression through the cell cycle. Which of the following determines progression beyond the
restriction point in G1?
Select one:
a. The presence of cyclin and Cdk.
O b. The presence of cyclin.
c. Phosphorylation of RB by Cdk.
d. The presence of external signals from growth factors.
e. The absence of cyclin.
One example of an oncogene is ras. Ras is a G protein that is activated when growth factors bind to a G protein-coupled receptor. The mutated form of ras binds to GTP but does not allow the GTP to be broken down to GDP. Ras is involved in both the G1G1 and G2G2 checkpoints.
What happens to cells that have this mutated form of ras?
A.
They divide when they should not.
B.
They don’t divide when they should.
C.
They enter mitosis without going through the S phase of the cell cycle.
D.
They enter cytokinesis without going through the M phase of the cell cycle.
Chapter 12 Solutions
Study Guide for Campbell Biology
Ch. 12 - a. How many chromosomes are in your somatic cells?...Ch. 12 - a. What event is common to all three subphases of...Ch. 12 - The following diagrams will depict the five stages...Ch. 12 - a. What is MPF? b. Describe the relative...Ch. 12 - In the following photomicrograph of onion root tip...Ch. 12 - Describe one chromosome as it proceeds through an...Ch. 12 - Draw a sketch of one half of a mitotic spindle....Ch. 12 - FILL IN THE BLANK: Identify the appropriate phase...Ch. 12 - FILL IN THE BLANK: Identify the appropriate phase...Ch. 12 - Prob. 3TYKF
Ch. 12 - Prob. 4TYKFCh. 12 - Prob. 5TYKFCh. 12 - Prob. 6TYKFCh. 12 - FILL IN THE BLANK: Identify the appropriate phase...Ch. 12 - Prob. 8TYKFCh. 12 - Prob. 9TYKFCh. 12 - FILL IN THE BLANK: Identify the appropriate phase...Ch. 12 - One of the differences between prokaryotic binary...Ch. 12 - Prob. 2TYKCh. 12 - Prob. 3TYKCh. 12 - Prob. 4TYKCh. 12 - Prob. 5TYKCh. 12 - In eukaryotic organisms, chromosomes are...Ch. 12 - Prob. 7TYKCh. 12 - Prob. 8TYKCh. 12 - Prob. 9TYKCh. 12 - Prob. 10TYKCh. 12 - During cell division, cyclin combines with...Ch. 12 - Prob. 12TYKCh. 12 - Prob. 13TYKCh. 12 - Prob. 14TYKCh. 12 - Vinblastine is a chemotherapeutic drug used to...
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- Which of the following is a characteristic of a cell undergoing cellular senescence? a.Doubling in physical size b.Production of SASPs c.Atypically low NGF1-A levels d.Abnormally high rate of proliferationarrow_forwardWith regard to cancer cells, which of the following statementsare true?A. Cancer cells are clonal, which means they are derived from asingle mutant cell.B. To become cancerous, cells usually accumulate multiplegenetic changes that eventually result in uncontrolledgrowth.C. Most cancers are caused by oncogenic viruses.D. Cancer cells have lost the ability to properly regulate celldivision.arrow_forwardA tumor suppressor gene regulates the cell cycle; an example is . Select one: a. positively, p21 b. negatively, cyclin c. positively, retinoblastoma d. negatively, retinoblastoma e. positively, RAS Cycle HW due Jump to. 4) Next pa cancer stem cellsarrow_forward
- Why would the failure of the p53 tumor supressor gene be more likely to cause cancer in a seventy year old person compared to a ten year old person? Group of answer choices A. the p53 gene never works well in old people B. cells divide more rapidly as people get older C.The seventy year old is more likely to have pre-existing failures in cell cycle control D. there are fewer mutations in genes controlling the cell cycle in older peoplearrow_forwardWhich of the following is the primary method by which cyclin proteins are regulated to influence entry into the cell cycle or transition from one stage to the next? A. Transcriptional upregulation and translation followed by targeted ubiquitin-mediated degradation by a proteasome. B. Phosphorylation to regulate the activity of the kinase site. C. An activating phosphorylation and an inactivating phosphorylation. D. All of these are mechanisms that can be used to regulate cyclins.arrow_forwardThe following diagram indicates how the cell cycle progresses in typical human cells: INTERPHASE G₁ MITOTIC (M) PHASE Mitosis Cytokinesis DRUG S (DNA synthesis) G2 Suppose that you are investigating potential drugs that might be used to stop the out of control growth of tumor cells. The following table lists several experimental drugs along with some information about their effect on cells. Predict which stage of the cell cycle might be inhibited by each of the drugs (A through E). COMMENTS Shown to block thearrow_forward
- P53 is a tumor suppressors protein. The protein is present in the cell at all times but is activated by protein kinases that are, in turned activated by DNA damage. A mutation of the P 53 gene in cell results in a form of P53 that is permanently active. What would happen to the mutant version of the P53 gene? Group of answer choices A. it would spread to neighboring cells but not very far B. it would be found in tumor cells only C. it would take over the world and make us all do its bidding D. it would only be found in the original cell in which the mutation occurred E. it would spread to all cells in the bodyarrow_forwardLooking at the the time intervals in the figure given, compare the time spent in mitosis with the time spent in gap1 in human liver cells. A. less time is spent in G1 than in M B. a little more time is spent in G1 than in M C. The cell spends 10 hours less in G1 than it does in M D. The cell spends 10 hours more in G1 than it does in Marrow_forwardWhat would be the most likely effect of a mutation that causes cyclin B to be unable to bind to CDK? a. Cells pass through the G2/M checkpoint and enter mitosis even when DNA has not been replicated. b. Cells never pass through the G1/S checkpoint. c. Cells pass through mitosis more quickly than nonmutated cells. d. Cells fail to pass through the G2/M checkpoint and do not enter mitosis.arrow_forward
- The protein that ensures the fidelity of DNA replication is the a. tumor repressor P53 protein. b. Mitotic arrest deficient protein. c. transcription factor E2F protein. d. Ataxia telangiectasia mutated protein.arrow_forwardCell cycle regulation is important to ensure that a. non-dividing cells enter the G0 stage. b. dividing cells produce normal and viable daughter cells. c. the stages in both interphase and M phase are strictly followed. d. materials for cell division are complete and properly distributed. Which of the following complexes contributes to the transcription of cyclin E? a. Cdk1/cyclin A b. Cdk2/cyclin B c. Cdk3/cyclin C d. Cdk4/cyclin Darrow_forwardP53 is a tumor suppressor protein. The protein is present in the cell at all times but is activated by protein kinases that are, in turned activated by DNA damage. What would be the result of a mutation of the P 53 gene in cell that resulted in a form of P53 that was permanently active? Group of answer choices A. the cell cycle would be inhibited in all cells in a tumor if it forms B. the cell cycle would be inhibited C. the cell would form a tumor D. the cell has a higher probability of forming a tumor E. the cell cycle of all cells in the body would be inhibitedarrow_forward
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