Study Guide for Campbell Biology
11th Edition
ISBN: 9780134443775
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece, Martha R. Taylor, Michael A. Pollock
Publisher: PEARSON
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Chapter 12, Problem 11TYK
During cell division, cyclin combines with cyclin-dependent kinase (Cdk) to form a complex called MPF. This complex
- a. moves the cell past the G2 checkpoint into mitosis.
- b. ensures that DNA has been repaired prior to S phase of mitosis.
- c. promotes the degradation of cyclin, but leaves Cdk intact.
- d. both a and c
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Students have asked these similar questions
Cyclins and cyclin-dependent kinases regulate progression through the cell cycle. Which of the following determines progression beyond the
restriction point in G1?
Select one:
a. The presence of cyclin and Cdk.
O b. The presence of cyclin.
c. Phosphorylation of RB by Cdk.
d. The presence of external signals from growth factors.
e. The absence of cyclin.
Which of the following statements about the cell cycle is TRUE?
a. The protein APC blocks cells from entering anaphase
b. CDKs are degraded after each cell cycle phase by the addition of a ubiquitin chain to the proteins
c. A kinase is a protein that adds a ubiquitin chain to other proteins Cyclin activity is necessary, but not always sufficient, for CDK activation
d. Cyclin proteins must be degraded before Cdk proteins can be activated
Which of the following is the primary method by which cyclin proteins are regulated to influence entry into the cell cycle or transition from one stage to the next?
A.
Transcriptional upregulation and translation followed by targeted ubiquitin-mediated degradation by a proteasome.
B.
Phosphorylation to regulate the activity of the kinase site.
C.
An activating phosphorylation and an inactivating phosphorylation.
D.
All of these are mechanisms that can be used to regulate cyclins.
Chapter 12 Solutions
Study Guide for Campbell Biology
Ch. 12 - a. How many chromosomes are in your somatic cells?...Ch. 12 - a. What event is common to all three subphases of...Ch. 12 - The following diagrams will depict the five stages...Ch. 12 - a. What is MPF? b. Describe the relative...Ch. 12 - In the following photomicrograph of onion root tip...Ch. 12 - Describe one chromosome as it proceeds through an...Ch. 12 - Draw a sketch of one half of a mitotic spindle....Ch. 12 - FILL IN THE BLANK: Identify the appropriate phase...Ch. 12 - FILL IN THE BLANK: Identify the appropriate phase...Ch. 12 - Prob. 3TYKF
Ch. 12 - Prob. 4TYKFCh. 12 - Prob. 5TYKFCh. 12 - Prob. 6TYKFCh. 12 - FILL IN THE BLANK: Identify the appropriate phase...Ch. 12 - Prob. 8TYKFCh. 12 - Prob. 9TYKFCh. 12 - FILL IN THE BLANK: Identify the appropriate phase...Ch. 12 - One of the differences between prokaryotic binary...Ch. 12 - Prob. 2TYKCh. 12 - Prob. 3TYKCh. 12 - Prob. 4TYKCh. 12 - Prob. 5TYKCh. 12 - In eukaryotic organisms, chromosomes are...Ch. 12 - Prob. 7TYKCh. 12 - Prob. 8TYKCh. 12 - Prob. 9TYKCh. 12 - Prob. 10TYKCh. 12 - During cell division, cyclin combines with...Ch. 12 - Prob. 12TYKCh. 12 - Prob. 13TYKCh. 12 - Prob. 14TYKCh. 12 - Vinblastine is a chemotherapeutic drug used to...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Cell cycle regulation is important to ensure that a. non-dividing cells enter the G0 stage. b. dividing cells produce normal and viable daughter cells. c. the stages in both interphase and M phase are strictly followed. d. materials for cell division are complete and properly distributed. Which of the following complexes contributes to the transcription of cyclin E? a. Cdk1/cyclin A b. Cdk2/cyclin B c. Cdk3/cyclin C d. Cdk4/cyclin Darrow_forwardProgression through the cell cycle is dependent on both extra- and intracellular conditions. Consider the following conditions. Indicate which checkpoint (s) responds to that condition.a. The cell is large enough to divide.b. The DNA is completely copied during S phase.c. The cell is receiving positive cues from neighbors.d. The DNA is damaged.e. The cell has enough energy reserves to divide.f. Are all the sister chromatids correctly attached to spindle microtubules?arrow_forwardA tumor suppressor gene regulates the cell cycle; an example is . Select one: a. positively, p21 b. negatively, cyclin c. positively, retinoblastoma d. negatively, retinoblastoma e. positively, RAS Cycle HW due Jump to. 4) Next pa cancer stem cellsarrow_forward
- Which of the following is a change to the CdK/cyclin system that could result in cell division followed by cell death? Group of answer choices A. Increased production of CdK B. Decreased production of cyclin during G2 C. Increased production of cyclin during G2 D. Cyclin not broken down by mitosis E. Breakdown of CdK by mitosisarrow_forwardChoose the item in column 2 that best matches each item in column 1. Cdk APC ced mutants EGF A. direct regulation of cell cycle processes B. chromosome separation or cytokinesis mechanisms C. mitogen signaling pathways D. apoptosisarrow_forwardThis begins early in the telophase and continues after the nucleus has formed in the daughter cells. a. cytokinesis b. interphase c. apoptosis d. differentiationarrow_forward
- Which of the following statements is a lie?Select one: a. If damaged DNA is detected during the cell cycle, negative regulation is responsible in stopping the cell cycle. b. There are four cyclin proteins involved in the positive regulation of the cell cycle and they have fluctuating levels. c. To activate cyclin-dependent kinases (Cdks), they must bind to another kinase.arrow_forwardIn a healthy cell, which of the following proteins will be activated in order to suppress cell division if the cell is not ready or should not divide? Select one: a. p53 b. cdk c. cyclin d. seperase e. mitogenarrow_forwardA tumor suppressor gene ___regulates the cell cycle; an example is _____. Select one: a. negatively, cyclin b. positively, retinoblastoma c. positively, p21 d. negatively, retinoblastoma e. positively, RASarrow_forward
- When regulating the cell cycle of eukaryotic cells, a critical protein we discussed was cyclin. Cyclin is Select one: a. Always present in all stages of the cell cycle, but only active during the G1 - R transition b. Produced in response to signals for the cell to divide c. Produced only when retinoblastoma protein is inactivated d. Produced in response to the presence of cyclin-dependent kinasearrow_forwardCytokinesis occurs A. Just before telophase B. At the end of mitosis C. At the end of prophase D. At the end of G1arrow_forwardBPA is a chemical compound that has historically been used in the manufacture of plastic products. However, cells often mistake BPA molecules for hormones that accelerate the cell cycle. Because of this, BPA is associated with an increased risk of certain cancers.a. How might BPA interact with the cell cycle and its checkpoints?b. Why do you think that very small concentrations of BPA might have a large effect on a cell?arrow_forward
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