Interpretation:
Whether the acid-catalyzed hydrolysis of acetamide is a reversible or irreversible reaction has to be found and explained.
Concept introduction:
Acid catalyzed reaction: In acid hydrolysis of amide, acid protonates carbonyl oxygen of amide which increases the electrophilicity of the carbonyl carbon. Water acts as a nucleophile gets attached to the carbonyl carbon of amide to form tetrahedral intermediate(A) which on losing proton get converted to tetrahedral intermediate(B). The nitrogen of tetrahedral intermediate (B) gets protonated to form tetrahedral intermediate(C). The
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Essential Organic Chemistry, Global Edition
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