To explain: Under what conditions might receptor up-regulation occur.
Introduction: Cell is the fundamental unit of life. Cells communicate with each other by a process known as cell signaling. It is important for an organism to receive and respond to the stimulus. This is helpful for growth, development, and functioning of the cells of the multicellular organism.
To explain: Under what conditions might receptor down-regulation occur.
Introduction: Cell is the fundamental unit of life. Cells communicate with each other by a process known as cell signaling. It is important for an organism to receive and responds to the stimulus. This is helpful for growth, development, and functioning of the cells of the multicellular organism.
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Biology (MindTap Course List)
- Explain , What role does phosphorylation of tyrosine residues play in the action of receptor proteins?arrow_forwardIllustrate a major way that receptor activation ceases?arrow_forwardWhat is allosteric regulation? Describe HOW allosteric regulation acts like an “on/off” switch for signal pathway receptors and WHY it is important to be able to turn a receptor off.arrow_forward
- When a G-coupled receptor is activated, does the By subunit activate any pathways? If yes, describe which pathway. If no, then why do you think the By subunit exists?arrow_forwardUpon activation by a receptor, a G protein exchanges bound GDP for GTP, rather than phosphorylating GDP that is already bound. Similarly, the a subunit-GTP complex has a slow GTPase activity that hydrolyzes bound GTP, rather than exchanging it for GDP. Describe experimental evidence that would be consistent with these conclusions.arrow_forwardExplain which component does the KDEL receptor bind its ligand more tightly and more weakly.arrow_forward
- Briefly explain the difference between a receptor antagonist and a receptor inverse agonist. Describe both the resulting receptor conformation as well as the signal transduction.arrow_forwardHow is down-regulation possible in regulation receptors?arrow_forwardThe activation of receptor tyrosine kinases is characterized by(A) dimerization and phosphorylation.(B) dimerization and IP3 binding.(C) a phosphorylation cascade.(D) GTP hydrolysis.arrow_forward
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