Human Physiology
15th Edition
ISBN: 9781259864629
Author: Fox, Stuart Ira
Publisher: Mcgraw-hill Education,
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Chapter 6, Problem 32RA
Summary Introduction
To review:
The role of antidiuretic hormone (ADH) on the epithelial cells of the kidney in making it more permeable to water.
Introduction:
Hormones are the chemical signals that regulate different physiological processes. They are secreted by the exocrine and endocrine glands. The exocrine glands release their chemicals in the ducts that transport them to the required sites, whereas the endocrine glands release their secretions into the blood from where they are carried to the sites.
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What concentration of sucrose do you estimate would yield no change inpressure? Why is this biologically significant? Explain in your own words. Do not copy and paste from google. Please refer to your data/graphs on Dialysis tubing cell osmosis.
Epithelial cells that reabsorb solutes are cuboidal, but epithelial cells involved in filtration are thin, squamous cells. The cuboidal cells contain more cytoplasm and organelles, especially mitochondria and rough endoplasmic reticulum (RER), than the squamous cells. Why do the cuboidal cells of the kidney tubules need more mitochondria and RER?
Answer a,
Anti-Diuretic Hormone (ADH) and Aldosterone both target kidney cells and increase water retention (keeping water in the blood, letting less go out with urine).
ADH causes water retention directly- kidney cells let more water move from the urine back into the blood (the cells are a barrier between those two spaces).
Aldosterone enhances water retention by causing more sodium to be retained, creating a stronger osmotic gradient. However, aldosterone also causes a loss of potassium to the urine for every sodium that is kept in the blood.
a. Are these hormones both water-soluble or fat-soluble, or is there one of each?
b. What chemical class does each belong to?
c. Draw a picture hypothesizing how each might cause its target cells to have their effects. Don't look it up! You have all the information you need from the notes and explanation in this question to come up with a reasonable, logical hypothesis.
d. If somebody has hyper-aldosteronism (secrete too much aldosterone,…
Chapter 6 Solutions
Human Physiology
Ch. 6 - Describe the distribution of fluid in the body.Ch. 6 - Describe the composition of the extracellular...Ch. 6 - List the subcategories of passive transport and...Ch. 6 - Explain what is meant by simple diffusion and list...Ch. 6 - Prob. 4CPCh. 6 - Prob. 5CPCh. 6 - Explain how the body detects changes in the...Ch. 6 - Prob. 7aCPCh. 6 - Prob. 7bCPCh. 6 - Prob. 7cCP
Ch. 6 - Prob. 8CPCh. 6 - Prob. 9aCPCh. 6 - Prob. 9bCPCh. 6 - Explain the relationship of the resting membrane...Ch. 6 - Prob. 10bCPCh. 6 - Prob. 11CPCh. 6 - Prob. 12CPCh. 6 - The movement of water across a plasma membrane...Ch. 6 - Which of these statements about the facilitated...Ch. 6 - Prob. 3RACh. 6 - Prob. 4RACh. 6 - Blood plasma has an osmolality of about 300 mOsm....Ch. 6 - Prob. 6RACh. 6 - The most important diffusible ion in the...Ch. 6 - Prob. 8RACh. 6 - Prob. 9RACh. 6 - Prob. 10RACh. 6 - Prob. 11RACh. 6 - Prob. 12RACh. 6 - Prob. 13RACh. 6 - Prob. 14RACh. 6 - Which of the following questions regarding second...Ch. 6 - Prob. 16RACh. 6 - Prob. 17RACh. 6 - Compare the resting membrane potential of a neuron...Ch. 6 - Prob. 19RACh. 6 - Prob. 20RACh. 6 - Prob. 21RACh. 6 - Prob. 22RACh. 6 - Using the principles of osmosis, explain why...Ch. 6 - Prob. 24RACh. 6 - Prob. 25RACh. 6 - Prob. 26RACh. 6 - Prob. 27RACh. 6 - Prob. 28RACh. 6 - Prob. 29RACh. 6 - Prob. 30RACh. 6 - Using only the information in this chapter,...Ch. 6 - Prob. 32RACh. 6 - Prob. 33RACh. 6 - Suppose a semipermeable membrane separates two...Ch. 6 - Prob. 35RACh. 6 - Prob. 36RACh. 6 - Use the Nernst equation and the ion concentration...
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- The Na+-glucose transporters SGLT2 and SGLT1 are located at different levels of the kidney proximal tubule to minimize spillover of the glucose into the urine (See diagram attached) a) Consider the Na+-glucose coupling ratios for SGLT2 and SGLT1. Why would localization of SGLT2 in the early proximal tubule and SGLT1 in the late proximal tubule be advantageous? b) The Michaelis constant (Km) for the SGLT2 and SGLT1 transporters are 2 mM and 0.5 mM, respectively. Is SGLT2 or SGLT1 the higher affinity Na+-glucose transporter? d) Dapagliflozin is an SGLT1 inhibitor and commonly prescribed to treat type 2 diabetes. Why would this be of benefit to a diabetes patient?arrow_forwardOne type of diuretic given to people with high blood pressure, renal disease and congestive heart failure are thiazide-type diuretics. These drugs inhibit sodium ion reabsorption by inhibiting the transport in the ascending limb of the loop of Henle. A) What does it mean to inhibit the transport of sodium ions in the loop of Henle? B) Explain how this inhibition of sodium ions in the loop of Henle could help increase urine production.arrow_forwardExplain the mechanism how furosemide affects kidney tubules. How does this affect K+ balance? How different is the mechanism of thiazide affect urine production? Describe the process of acid-base regulation in human body.arrow_forward
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- A patient has essential hypertension, and with a healthy lifestyle and medication, he is able to maintain normal blood pressure on a single antihypertensive medication. The medication he takes is called an angiotensin converting enzyme inhibitor, or ACE inhibitor, which blocks the activation of angiotensin II. Describe at least two mechanisms by which angiotensin II targets the kidneys to increase extracellular fluid volume and, therefore, increase blood pressure.arrow_forwardIn a person with diabetes mellitus, what would be causing polyuria? Glucose has saturated the secondary active transporters in the PCT that move glucose into the cells, increasing the concentration gradient between the filtrate and the ISF or Glucose has saturated the secondary active transporters in the PCT that move glucose into the cells, reducing the concentration gradient between the filtrate and the ISFarrow_forwardMy mother who is a type 2 diabetes mellitus patient is taking empagliflozin, a SGLT2 inhibitor, for the treatment of hyperglycaemia. Based on your knowledge on renal physiology, what is the mechanism of action of a SGLT2 inhibitor? [No pharmacology details needed ]arrow_forward
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