Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 5, Problem 24PDQ
The genes encoding the red- and green-color-detecting proteins of the human eye are located next to one another on the X chromosome and probably evolved from a common ancestral pigment gene. The two proteins demonstrate 76 percent homology in their amino acid sequences. A normal-visioned woman with both genes on each of her two X chromosomes has a red- color-blind son who was shown to have one copy of the green-detecting gene and no copies of the red-detecting gene. Devise an explanation for these observations at the chromosomal level (involving meiosis).
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One of the X chromosomes in a particular Drosophila female had a normal order of genes but carried recessive alleles of the genes for yellow body color (y), vermilion eye color (v), and forked bristles (f), as well as the dominant X-linked Bar eye mutation (B). Her other X chromosome carried the wild-type alleles of all four genes, but the region including y+, v+, and f+ (but not B+) was inverted with respect to the normal order of genes. This female was crossed to a wild-type male in the cross diagrammed her.
The cross produced the following male offspring:
Y
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B+
11
y+
v+
f+
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y+
v+
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B+
1
a. Why are there no male offspring with the allele combinations y v f+, v+ v+ f, y v+ f+, or y+ v f (regardless of the allele of the Bar eye gene)?
b.What kinds of crossovers produced the y v f b+ and v+ y+ f+ B offspring? Can you determine any genetic distances from these classed of progeny?
c. What kinds of crossovers produced the…
One of the X chromosomes in a particular Drosophila female had a normal order of genes but carried recessive alleles of the genes for yellow body color (y), vermilion eye color (v), and forked bristles (f), as well as the dominant X-linked Bar eye mutation (B). Her other X chromosome carried the wild-type alleles of all four genes, but the region including y, v, and f (but not B) was inverted with respect to the normal order of genes. This female was crossed to a wild-type male as diagrammed here.
1. Draw the meiotic prophase I chromosomes with maximal pairing from the inversion heterozygous female.
2. (continued) When a crossover occurs between v and f, please draw the resulting chromosomes in four gametes.
A male Drosophila with wild-type phenotype is discovered to have only seven chromosomes, whereas normally 2n = 8. Close examination reveals that one member of chromosome IV (the smallest chromosome) is attached to (translocated to) the end of chromosome II. If this male mates with a female with a normal chromosome composition who is homozygous for the recessive chromosome IV mutation eyeless (genotype = ee), what would be the eye genotypes, eye phenotypes, and total number of chromosomes in all potential offspring if the male is homozygous for the wild-type allele (EE)?
Chapter 5 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. 5 -
CASE STUDY | Doggone it!
A dog breeder...Ch. 5 - CASE STUDY| Doggone it! A dog breeder discovers...Ch. 5 - CASE STUDY| Doggone it! A dog breeder discovers...Ch. 5 -
CASE STUDY | Doggone it!
A dog breeder...Ch. 5 - HOW DO WE KNOW? In this chapter, we have focused...Ch. 5 - Review the Chapter Concepts list on p. 84. These...Ch. 5 - As related to sex determination, what is meant by...Ch. 5 -
4. Contrast the life cycle of a plant such as...Ch. 5 - Prob. 5PDQCh. 5 -
6. Describe the major difference between sex...
Ch. 5 - How do mammals, including humans, solve the...Ch. 5 -
8. What specific observations (evidence) support...Ch. 5 - Describe how nondisjunction in human female...Ch. 5 -
10. An insect species is discovered in which the...Ch. 5 -
11. Given your answers to Problem 10, is it...Ch. 5 - When cows have twin calves of unlike sex...Ch. 5 -
13. An attached-X female fly, XXY (see the...Ch. 5 -
14. Assume that on rare occasions the attached X...Ch. 5 - It is believed that any male-determining genes...Ch. 5 -
16. What is a Barr body, and where is it found...Ch. 5 - Indicate the expected number of Barr bodies in...Ch. 5 - Define the Lyon hypothesis.Ch. 5 - Can the Lyon hypothesis be tested in a human...Ch. 5 - Predict the potential effect of the Lyon...Ch. 5 -
21. Cat breeders are aware that kittens...Ch. 5 -
22. What does the apparent need for dosage...Ch. 5 - In mice, the Sry gene (see Section 5.2) is located...Ch. 5 - The genes encoding the red- and...Ch. 5 - In mice, the X-linked dominant mutation Testicular...Ch. 5 -
26. Shown here are graphs that plot the...Ch. 5 -
27. In chickens, a key gene involved in sex...
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- A male Drosophila with wild-type phenotype is discovered to have only seven chromosomes, whereas normally 2n = 8. Close examination reveals that one member of chromosome IV (the smallest chromosome) is attached to (translocated to) the end of chromosome II. If this male mates with a female with a normal chromosome composition who is homozygous for the recessive chromosome IV mutation eyeless (genotype = ee), what would be the eye genotypes, eye phenotypes, and total number of chromosomes in all potential offspring if the male is homozygous for the wild-type allele (EE)? put a table for punnet squarearrow_forwardIn drosophila, a recessive mutation (m-) of a maternal effect gene results in an abnormal phenotype wherein homozygous (m-m-) females produce eggs that cannot support embryonic development. Homozygous (m-m-) males, however, can still produce viable sperm. (A) Using m+ to denote a normal gene, determine the genotypes and phenotypes of the F1s produce by a cross between a heterozygous female and a recessive male. (B) From the offspring, backcross the recessive female with the paternal strain. What are the genotypes and phenotypes of the F2s? (C) If m-m- females produce useless eggs, then how are m-m- produced?arrow_forwardIn drosophila, a recessive mutation (m-) of a maternal effect gene results in an abnormal phenotype wherein homozygous (m-m-) females produce eggs that cannot support embryonic development. Homozygous (m-m-) males, however, can still produce viable sperm. Using m+ to denote a normal gene, determine the genotypes and phenotypes of the F1s produce by a cross between a heterozygous female and a recessive male. From the offspring, backcross the recessive female with the paternal strain. 1. What are the genotypes and phenotypes of the F2s? 2. If m-m- females produce useless eggs, then how are m-m- produced?arrow_forward
- In drosophila, a recessive mutation (m-) of a maternal effect gene results in an abnormal phenotype wherein homozygous (m-m-) females produce eggs that cannot support embryonic development. Homozygous (m-m-) males, however, can still produce viable sperm. Using m+ to denote a normal gene, determine the genotypes and phenotypes of the F1s produce by a cross between a heterozygous female and a recessive male. From the offspring, backcross the recessive female with the paternal strain. What are the genotypes and phenotypes of the F2s? Show COMPLETE cross for both cases. If m-m- females produce useless eggs, then how are m-m- produced?arrow_forwardIn humans, color vision depends on genes encoding three pigments. The R (red pigment) and G (green pigment) genes are close together on the X chromosome, whereas the B (blue pigment) gene is autosomal. A recessive mutation in any one of these genes can cause color blindness. Suppose that a color-blind man married a woman with normal color vision. The four sons from this marriage were color-blind, and the five daughters were normal. Specify the most likely genotypes of both parents and their children, explaining your reasoning. (A pedigree drawing will probably be helpful.) (Problem 50 is by Rosemary Redfield.)arrow_forwardMale Drosophila from a true-breeding wild-type stock were irradiated with X-rays and then mated with females from a true-breeding stock carrying the following recessive mutations on the X chromosome: yellow body (y), crossveinless wings (cv), cut wings (ct), singed bristles (sn), and miniature wings (m). These markers are known to map in the order: Recessive alleles: y, cv, ct, sn, m Dominant alleles: y+, cv+, ct+, sn+, m+ y-cv-ct-sn-m у CV ct sn m X-rays х х X ct sn CV у m y+ CV+ ct+ sn+ m+ х X ? Exceptional female: Most of the female progeny of this cross were phenotypically wild type, but one female exhibited ct and sn mutant characteristics. When this exceptional ct sn female was mated with a male from the true-breeding wild-type stock, twice as many females as males appeared among the progeny. a. What is the nature of the X-ray-induced mutation present in the exceptional female? b. Draw the X chromosomes present in the exceptional ct sn female as they would appear during pairing…arrow_forward
- In Drosophila, the genes ct(cut wing margin), y (yellow body), and v (vermilion eye color) are X-linked. Females heterozygous for all three markers were mated with wildtype males and the following male progeny were obtained. As is conventional in Drosophila genetics, the wild-type allele of each gene is designated by a “+” sign in the appropriate column. Use the data to (A) create a genetic map of the genes, (B) calculate interference, and (C) interpret the value of interference. Show your work.arrow_forwardThe mutant genes for vestigial wings and singed bristles are approximately 30 map units apart on chromosome II in Drosophila. Assume that a vestigial-winged female was mated to a singed-bristle male, and that the resulting F1 phenotypically wild type females were mated to vestigial singed males. Of 1000 offspring, which phenotype class would represent the product of crossing over between the genes, and how many would you expect? a) vestigial, 300 flies b) vestigial, 150 flies wild type, 300 flies d) singed, 150 flies e) vestigial, singed double mutants, 150 fliesarrow_forwardA maternal effect gene in Drosophila, called torso, is found as a recessive allele that prevents the correct development of anterior- and posterior-most structures. A wild-type (homozygous) male is crossed to a female of unknown genotype. This mating produces 100% larva that are missing their anterior- and posterior-most structures and therefore die during early development. What is the genotype and phenotype of the female fly in this cross? What are the genotypes and phenotypes of the female fly’s parents? Show COMPLETE cross.arrow_forward
- In a human genetic study, a family with five phenotypicallynormal children was investigated. Two children were “homozygous”for a Robertsonian translocation between chromosomes19 and 20 (they contained two identical copies of the fusedchromosome). They have only 44 chromosomes but a completegenetic complement. Three of the children were “heterozygous”for the translocation and contained 45 chromosomes,with one translocated chromosome plus a normal copy of bothchromosomes 19 and 20. Two other pregnancies resulted instillbirths. It was later discovered that the parents were firstcousins. Based on this information, determine the chromosomecompositions of the parents. What led to the stillbirths? Whywas the discovery that the parents were first cousins a key pieceof information in understanding the genetics of this family?arrow_forwardIn Drosophila, the X-linked recessive mutation vermilion (v) causes bright red eyes, in contrast to the brick-red eyes of wild type. A separate autosomal recessive mutation, suppressor of vermilion (su-v), causes flies homozygous or hemizygous for v to have wildtype eyes. In the absence of vermilion alleles, su-v has no effect on eye color. Determine the F1 and F2 phenotypic ratios from a cross between a female with wild-type alleles at the vermilion locus, but who is homozygous for su-v, with a vermilion male who has wildtype alleles at the su-v locusarrow_forwardVermillion eye color in Drosophila sp. is a sex-linked recessive trait. What phenotype would be found in this progeny of a cross between a vermillion female and a wild type male?arrow_forward
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