Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 44.2, Problem 1R
Summary Introduction
To review:
The reason due to, which the Goldman equation is able to produce a more reliable calculation of resting membrane potential as compared to the Nernst equation.
Introduction:
The resting membrane potential is maintained by the efflux of potassium ions (K+) and the influx of the sodium ions (Na+) inside the cell with the help of the sodium-potassium pump. The concentration of the K+ across the membrane is calculated once equilibrium is established between them. This is calculated by using Nernst equation. The Goldman equation, however, also involves the following:
All ions, which are capable of crossing the membrane.
The relative permeability provided by the membrane to all the ions.
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What is the equilibrium membrane potential due to Na+
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Why is the sodium-potassium pump indirectly important to the ac-tion potential and to maintaining the resting membrane potential?
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- Conformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)arrow_forwardOne of the important uses of the Nernst equation is in describing the flow of ions across plasma membranes. Ions move under the influence of two forces: the concentration gradient (given in electrical units by the Nernst equation) and the electrical gradient (given by the membrane voltage). This is summarized by Ohms law: Ix=Gx(VmEx) which describes the movement of ion x across the membrane. I is the current in amperes (A); G is the conductance, a measure of the permeability of x, in Siemens (S), which is I/V;Vm is the membrane voltage; and Ex is the equilibrium potential of ion x. Not only does this equation tell how large the current is, but it also tells what direction the current is flowing. By convention, a negative value of the current represents either a positive ion entering the cell or a negative ion leaving the cell. The opposite is true of a positive value of the current. a. Using the following information, calculate the magnitude of Na [ Na+ ]0=145mM,[ Na+ ]i=15mM,Gna+=1nS,Vm=70mV b. Is Na+ entering or leaving the cell? c. Is Na+ moving with or against the concentration gradient? Is it moving with or against the electrical gradient?arrow_forwardDescribe the contribution of each of the following to establishing and maintaining membrane potential: (a) the Na+K+ pump, (b) passive movement of K+ across the membrane, (c) passive movement of Na+ across the membrane, and (d) the large intracellular anions.arrow_forward
- Voltage-gated Na+ channels open upon leaching what state? resting potential threshold repolaiization overshootarrow_forwardHyperkalemia is a condition by which ECF potassium levels become too high (usually due to kidney failure). Consider the following questions about the consequence of hyperkalemia on membrane potential. How would hyperkalemia affect EK? Considering your answer to the previous question, how would hyperkalemia affect membrane potential?arrow_forward• Describe the concept of transport maximum (Tm). • Explain the membrane potential and the equilibrium potential. • What information does the Nernst Equation provide? What is the limitation inherent to the Nernst Potential?arrow_forward
- Calculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). (a)Membrane permeable only to Na+.arrow_forwardCalculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). Membrane permeable only to Cl−.arrow_forwardWhat is the equilibrium membrane potential due to Na+ ions if the extracellular concentration of Na+ ions is 154 mM and the intracellular concentration of Na+ ions is 27 mM at 20 ∘C ? Please answer asap and in short and content should not be palgarised pleasearrow_forward
- What role do the Na+/K+ pumps play in establishing the resting membrane potential?arrow_forwardHow does the movement of ICF K+ ions down its concentration gradient affect membrane potential?arrow_forwardWhich factors determine the resting membrane potential? Explain why the resting membrane potential is never really the value calculate by the Nernst equation for the potassium equilibrium potential. comments : please answer me in a correct way to hence my knowledge and for my better understandingarrow_forward
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