Campbell Biology
Campbell Biology
12th Edition
ISBN: 9780135188743
Author: Urry
Publisher: PEARSON
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Chapter 43.1, Problem 2CC

MAKE CONNECTIONS Ø How do the molecules that activate the vertebrate TLR signal transduction pathway differ from the ligands in most other signaling pathways (see Concept 11.2)?

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Create a diagram which illustrates the typical signalling mechanism of action of nuclear receptors and possible routes of communication (autocrine etc.). Should show the specific molecules involved, the mechanisms of signal transduction and indicate the different pathways thgt are activated. It should include a specific example of a receptor, ligand and signalling pathway for each general class. Include as wide a variety of ligands and modes of action as you can. for a novel pathway. Superfamily Give the superfamily to which the receptor belongs Accession Give the Uniprot accession number Name Give the molecule name Species Give the species Ligand What is the ligand, or class of ligands which bind to this receptor? Key physiological What are the physiological processes involved? Is this autocrine, paracrine or endocrine or some combination of them? What is the pathology of the receptor? process involved Mechanism of What are the downstream actions of the receptor? Which molecules does…
Compare and contrast GPCR and RTK receptors with respect to (a)structure (especially the transmembrane region), (b) activation mechanism, and (c) initial signal transduction across the membrane.
10-In GPCR signaling, the cleavage of PIP2 results in IP3 and: A. DAG B. CAMP C. Calcium D. Phospholipase C 11-Which of the following is a second messenger involved in alpha-adrenergic receptor signaling in liver cells: A) Glucagon B) cyclic AMP C) Calcium ions D) CO2 gas 12-Which of the following is a second messenger produced by the cleavage of PIP2 in GPCR signaling in liver cells: A. Protein kinase B. CAMP C. IP3 D. Phospholipase C 13-Which statement explains the involvement of apoptosis in Alzheimer disease? A. Apoptosis failure causes Alzheimer B. Alzheimer is caused by the death of all brain cells but not neurons. C. Alzheimer is caused by apoptosis activation in neuronal cells. D. None of brain diseases is related to apoptosis 14-Which of the following should be inhibited to block the release of calcium mediated by GPCR signaling from the endoplasmic reticulum? A. Protein kinase B. Phosphatase C. Adenylyl cyclase D. Phospholipase C 15-One of the following is an example of the…
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