Rb(retinoblastoma) gene and the effect of mutation in Rb gene. Cancer will occur in: A. one copy of rb are, both copies of E2F are functional. B. both copies of rbaredefective, both copies of E2F is defective. C. both the copies of rb are defective, one copy of E2F is defective. D. both copies of rb and E2F are defective. Introduction: Oncogenes are the genes that lead to uncontrolled growth of the cell. Another gene tumor suppressorgene when inactivated causes retinoblastoma, which occurs in the retina of the eye. Retinoblastoma is a type of cancer that develops from the light detecting tissue of the eye, retina. When it is inherited, it is likely to occur in early stages of life, and when not inherited causes a rare chance to happen in later stage of life.

Question

Want to see the full answer?

Answer 1

Question

Chapter 25, Problem 26CONQ

Summary Introduction

To review:

Rb(retinoblastoma) gene and the effect of mutation in Rb gene. Cancer will occur in:

A. one copy of rb are, both copies of E2F are functional.

B. both copies of rbaredefective, both copies of E2F is defective.

C. both the copies of rb are defective, one copy of E2F is defective.

D. both copies of rb and E2F are defective.

Introduction:

Oncogenes are the genes that lead to uncontrolled growth of the cell. Another gene tumor suppressorgene when inactivated causes retinoblastoma, which occurs in the retina of the eye. Retinoblastoma is a type of cancer that develops from the light detecting tissue of the eye, retina. When it is inherited, it is likely to occur in early stages of life, and when not inherited causes a rare chance to happen in later stage of life.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

A cell inherits a mutation in a gene that results in a transcription factor, called NF-kB, constantly being in its active conformation. When active, NF-kB stimulates the expression of cyclins that promote progression of the cell cycle, regardless of other conditions. As a result of this mutation, how would this cell's phenotype be affected by this mutation? A) This cell would have a cancer phenotype B) This cell would grow larger in size, but would never divide C) This cell would likely undergo apoptosis D) This cell would not duplicate its chromosomes .

The p53 gene was discovered in 1979, but it was not clear whether the gene functioned as an oncogene or a tumor-suppressor gene. Several years later, researchers showed that both p53 alleles are inactivated in some mouse cancers. This evidence suggests A. the p53 gene is an oncogene because inactivated alleles would produce mutated signal transduction proteins that would result in stimulating cell division. B. the p53 gene is an oncogene because the cell would overproduce transcription factors to compensate for the inactive alleles, resulting in increased cell division. C. the p53 gene is a tumor-suppressor gene because inactivated alleles indicate a loss of protein function which allowed the cancer to develop D. the p53 gene is a tumor-suppressor gene because the cell would produce too few transcription factors for gene activation, resulting in decreased cell division.

Cellular levels of tumor suppressor protein p53 is maintained by a ubiquitin ligase protein, called Mdm2. Over expression of Mdm2 destabilizes p53. Another protein p19ARF inhibits the activity of Mdm2, thus stabilizing p53. Loss of p19ARF function converts normal cells into cancer cells With the above information, which of the following statements are true? Mdm2 is a tumor suppressor gene but p19ARF is an oncogene Both Mdm2 & P19ARF are oncogenes Both Mdm2 & P19ARF are tumor suppressor genes O Mdm2 is an oncogene but p19ARF is a tumor suppressor gene