Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 25, Problem 16CONQ
Describe the two assumptions that underlie the identification of disease-causing alleles via haplotypes.
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A) what are the genotypes for EB27 and EB67?
B) what is the relationship between the three alleles (B,br, y)? Show evidence using the pedigree
Wild-type strains of the haploid fungus Neurospora canmake their own tryptophan. An abnormal allele td renders the fungus incapable of making its own tryptophan.An individual of genotype td grows only when its medium supplies tryptophan. The allele su assorts independently of td; its only known effect is to suppress the tdphenotype. Therefore, strains carrying both td and su donot require tryptophan for growth.a. If a td ; su strain is crossed with a genotypically wildtype strain, what genotypes are expected in the progenyand in what proportions?b. What will be the ratio of tryptophan-dependent totryptophan-independent progeny in the cross of part a?
Explain at the biochemical or enzymatic level, the phenotypic consequencesof alleles incase of following cross.
Rr (pink flower) x Rr (pink flower) (progeny are 1 RR (red flower) :2 Rr (pink flower): 1rr(white flower)
how alleles contribute to a phenotype through metabolism.
Chapter 25 Solutions
Genetics: Analysis and Principles
Ch. 25.1 - Which of the following wouldnotbe consistent with...Ch. 25.1 - 2. Assuming complete penetrance, which type of...Ch. 25.1 - 3. Which of the following is not a common...Ch. 25.1 - Prob. 4COMQCh. 25.2 - Prob. 1COMQCh. 25.2 - Haplotype association studies are aimed at the...Ch. 25.3 - 1. Which of the following is not a method used in...Ch. 25.3 - 2. Which of the following prenatal genetic testing...Ch. 25.4 - Prob. 1COMQCh. 25.5 - 1. An oncogene is produced from a ________that has...
Ch. 25.5 - Which of the following is a type of genetic change...Ch. 25.5 - 3. Tumor-suppressor genes promote cancer...Ch. 25.5 - 4. Normal (nonmutant) tumor-suppressor genes often...Ch. 25.5 - Prob. 5COMQCh. 25.6 - Prob. 1COMQCh. 25 - 1. With regard to pedigree analysis, make a list...Ch. 25 - 2. Explain, at the molecular level, why human...Ch. 25 - 3. Many genetic disorders exhibit locus...Ch. 25 - Prob. 4CONQCh. 25 - Prob. 5CONQCh. 25 - Figure 25.1 illustrates albinism in two different...Ch. 25 - Prob. 7CONQCh. 25 - Prob. 8CONQCh. 25 - Ehler-Danlos syndrome is a rare disorder caused by...Ch. 25 - 10. Hurler syndrome is due to a mutation in a gene...Ch. 25 - Like Hurler syndrome, Fabry disease involves an...Ch. 25 - Achondroplasia is a rare form of dwarfism caused...Ch. 25 - Prob. 13CONQCh. 25 - 14. Marfan syndrome is due to a mutation in a...Ch. 25 - 15. Sandhoff disease is due to a mutation in a...Ch. 25 - Describe the two assumptions that underlie the...Ch. 25 - Prob. 17CONQCh. 25 - What is a prion? Explain how a prion relies on...Ch. 25 - 19. Some people have a genetic predisposition for...Ch. 25 - What is the difference between an oncogene and a...Ch. 25 - Prob. 21CONQCh. 25 - Prob. 22CONQCh. 25 - Prob. 23CONQCh. 25 - Prob. 24CONQCh. 25 - Prob. 25CONQCh. 25 - Prob. 26CONQCh. 25 - Prob. 27CONQCh. 25 - With regard to cancer cells, which of the...Ch. 25 - Prob. 29CONQCh. 25 - 1. Which of the following experimental...Ch. 25 - Prob. 2EQCh. 25 - 3. What is meant by the term genetic testing? How...Ch. 25 - Prob. 4EQCh. 25 - 5. Chapter 21 describes a method known as Western...Ch. 25 - 6. An experimental assay for the blood-clotting...Ch. 25 - 7. Discuss ways to distinguish whether a...Ch. 25 - 8. The codon change (Gly-12 to Val-12) in...Ch. 25 - Explain how DNA microarrays are used in molecular...Ch. 25 - Make a list of the benefits that may arise from...Ch. 25 - 2. Our government has finite funds to devote to...Ch. 25 - Prob. 3QSDC
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- What advantages do anonymous DNA markers afford for genetic mapping as opposed to traditional allelic markers associated with visible phenotypes? What are the disadvantages of anonymous DNA markers for mapping?arrow_forwardRecognize progeny ratios that imply the existence ofrecessive lethal alleles.arrow_forwardRefer to the sequence characteristics of the alleles for Gene A (A1 = Allele 1 and A2 = Allele 2) below: Question: What DNA marker system can be developed for Gene A as characterized above, for example to study A-allele diversity? Briefly describe your proposed DNA marker i.e. concept overview, type/frequency/site of DNA mutation, method of resolution, genetic inheritance, etc.arrow_forward
- In the species Polyfarius obscescens, one gene controls lipid storage. Individuals with the dominant F allele are fat, and individuals homozygous for the f allele are not. Transgenic individuals that contain the GFP gene (which produces green fluorescent protein) have also been created. A geneticist has mated a P0 generation green and fat individual with another individual that is neither green nor fat. Using appropriate genetic nomenclature, list all of the possible genotypes of both parents.arrow_forwardIn Huntington’s disease, the wild-type allele, h, is recessive to the disease allele, H. The persistence of an autosomal dominant allele that is fatal in 100% of cases is best explained by which of the following? A) The dominant allele only has moderate negative effects during adolescence and young adulthood. B) The wild-type h allele continues to spontaneously mutate into the dominant H allele. C) The persistence of any given allele in nature is determined almost wholly by chance. D) The disease has no effects until the individual has reached an age far past the normal age for reproduction.arrow_forwardWhich of the following statements is/are true and which is/are false? The expression of lethal genes in heterozygotes is called penetrance. Expressivity is the balanced genetic output from a hemizygous condition.arrow_forward
- What is an allele is lethal only under certain conditions?arrow_forwardExplain how and why the same genotype can havedifferent phenotypes among individuals.arrow_forwardThe human MN blood group is determined by alleles (M and N) of a single gene that code for twO specific markers found on the surface of red blood cells. These alleles show a codominant pattern of expression. Blood typing of one family shows that the offspring all have the genotype MN. What are the most probable genotypes of the parents in this family? A)MM and NN B)ONN and MN C)MN and MN D)MM and MNarrow_forward
- A representation of the distance between genes or genetic markers is called a?arrow_forwardIn a study, an undergraduate student discovered a new enzyme involved in the metabolism of serotonin. This enzyme is made up of 3 subunits of the same protein. To characterize this enzyme, the student used genetic approaches to induce mutations in the coding region of the gene that codes for this protein and performed crosses to measure the effects of genotypes on enzyme activity. A) Indicate directly in the diagram (via a bar graph) the predicted relationship between genotype and enzyme activity. (Al represents the wild-type allele, A2 represents the mutant allele). A2A2 A1A2 A1Α1 B) Explain the reasoning for your prediction. Enzyme Activityarrow_forwardIn humans, four different blood types (A, B, AB, and O) are encoded by three alleles 1, 1, and i Individuals with both I and I alleles have blood type AB (red blood cells with both A and B antigens). Two copies of the i allele are required for an individual to have blood type O (red blood cells with no antigens). Which of the following correctly indicates the relationship between the I and / alleles for the blood type gene? Select one: OA. I is dominant to / OB. I is recessive to i OC. I and I are co-dominant OD. I and/exemplify incomplete dominancearrow_forward
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