Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 25, Problem 17P
Interpretation Introduction

Interpretation:

Reaction for the synthesis of dTMP from dUMP is to be determined.

Concept introduction:

Conversion of deoxyuridine monophosphate (dUMP) into deoxythymidine monophosphate (dTMP) is catalyzed by thymidine synthase enzyme. Thymidine is one of the nucleotides that is found in the DNA strand. If TS enzyme does not work properly, then it can lead to lack of thymidine and excess of uridine, which can cause DNA damage.

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