(a) Interpretation: The reason for the beneficial effects of ADP to ATP and AMP should be determined. Concept introduction: The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Question

Want to see the full answer?

Answer 1

Question

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

The Cori Cycle. Before vigorous exercise (at rest) the level of blood lactate is at its normal level (about 25 mM). During a 400 m sprint, the value rises sharply in less than a few minutes to about 200 mM and then declines slowly to around 40 mM over 60 mins after the sprint. a. Discuss (or illustrate) the pathway and reactions that cause the rapid increase in lactate concentration during the sprint. b. What causes the slow decline in lactate concentration after the sprint? Why does the decrease occur more slowly than the rapid increase? c. What enzymatic reaction is responsible for maintaining the lactate concentration above zero at recovery after the sprint?

Fo-F1 ATPase. The energy for ATP synthesis from ADP and Pi is provided by the downhill transport of protons through the rotary FoF1 ATP synthase . The enzyme has 3 alpha-beta and 12 ‘c’ subunits. The mitochondrion maintains change in membrane potential=180 mV (negative inside), pHin = 8, pHout=7, [Pi] = 3 mM and ADP is present as well. . What [ATP]/[ADP] ratio will be established at steady-state under these conditions? What would be the [ATP]/[ADP] ratio if the enzyme had only 9 ‘c’ subunits? full revolution of the crank (gamma subunit) produces 3 ATP.

disease. As such, a frontline treatment for Type 2 diabetes is the drug metformin, which acts indirectly to inhibit gluconeogenesis in the liver. You are a research biochemist who would like to develop new drugs that act to directly inhibit gluconeogenesis. You have just gained access to a library of thousands of small molecules of unknown activity, and you would like to identify lead compounds that have specific inhibitory activity against steps in the gluconeogenesis pathway. (a) into PEP in order to screen for inhibitors of enzymes specific to gluconeogenesis. Which enzymes do you need to purify, what cofactors and allosteric effectors do they require, and which reactants do you need to add to reconstitute the reactions for the first bypass? Which intermediates and products are generated? Your first approach is to reconstitute the initial set of bypass reactions that convert pyruvate (b) vitro reconstitution? What additional steps and enzymes are required in liver cells but are…

Answer 2

Question

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 5

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 6

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 7

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 10

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 11

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 12

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 13

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 14

Expert Solution & Answer

Answer 15

Expert Solution & Answer

Answer 16

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 17

Ch. 25 - Prob. 1P Ch. 25 - Prob. 2P Ch. 25 - Prob. 3P Ch. 25 - Prob. 4P Ch. 25 - Prob. 5P Ch. 25 - Prob. 6P Ch. 25 - Prob. 7P Ch. 25 - Prob. 8P Ch. 25 - Prob. 9P Ch. 25 - Prob. 10P

Solution Summary: The author explains the purine nucleotide cycle, where aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine.

Want to see the full answer?

Chapter 25 Solutions