Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 25, Problem 8P
Interpretation Introduction
Interpretation:
Sources of atoms in the purine ring should be determined.
Concept introduction:
Purine is a heterocyclic ring, which is composed of a pyrimidine ring fused with an imidazole ring. Adenine and guanine found in DNA and RNA are purines. It is oxidized into uric acid by the action of xanthine oxidase. Further, it is also involved in the formation of certain alkaloids, such as caffeine, and theophylline.
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Tracing carbon atoms 2. If cells synthesizing glucose from lactate are
exposed to CO2CO2 labeled with 14C,“C, what will be the
distribution of label in the newly synthesized glucose?
BIOMOLECULES
- Please answer the questions properly.
- Multiple choice
1. In human beings, what is the major control of de novo pyrimidine nucleotide synthesis?
A. substrate availability
B. feedback inhibition of glutamine-PRPP amidotransferase
C. competitive inhibition of carbamoyl phosphate synthetase II
D. availability of N-acetyl glutamate
2. In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not?
A. decrease de novo pyrimidine synthesis
B. increase PRPP levels (Phosphoribosyl pyrophosphate)
C. Decrease urate synthesis
D. decrease de novo purine synthesis
Ils applicatIC
2. How do you calculate the
charge of adsorbed species?
Chapter 25 Solutions
Biochemistry
Ch. 25 - Prob. 1PCh. 25 - Prob. 2PCh. 25 - Prob. 3PCh. 25 - Prob. 4PCh. 25 - Prob. 5PCh. 25 - Prob. 6PCh. 25 - Prob. 7PCh. 25 - Prob. 8PCh. 25 - Prob. 9PCh. 25 - Prob. 10P
Ch. 25 - Prob. 11PCh. 25 - Prob. 12PCh. 25 - Prob. 13PCh. 25 - Prob. 14PCh. 25 - Prob. 15PCh. 25 - Prob. 16PCh. 25 - Prob. 17PCh. 25 - Prob. 18PCh. 25 - Prob. 19PCh. 25 - Prob. 20PCh. 25 - Prob. 21PCh. 25 - Prob. 22PCh. 25 - Prob. 23PCh. 25 - Prob. 24PCh. 25 - Prob. 25PCh. 25 - Prob. 26PCh. 25 - Prob. 27PCh. 25 - Prob. 28PCh. 25 - Prob. 29PCh. 25 - Prob. 30PCh. 25 - Prob. 31PCh. 25 - Prob. 32PCh. 25 - Prob. 33PCh. 25 - Prob. 34PCh. 25 - Prob. 35PCh. 25 - Prob. 36PCh. 25 - Prob. 37PCh. 25 - Prob. 38PCh. 25 - Prob. 39PCh. 25 - Prob. 40PCh. 25 - Prob. 41PCh. 25 - Prob. 42PCh. 25 - Prob. 43PCh. 25 - Prob. 44PCh. 25 - Prob. 45PCh. 25 - Prob. 46PCh. 25 - Prob. 47PCh. 25 - Prob. 48PCh. 25 - Prob. 49PCh. 25 - Prob. 50PCh. 25 - Prob. 51P
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