Concept explainers
Interpretation:
Two substrates that contribute to the structure of the pyrimidine ring should be determined.
Concept introduction:
Pyrimidine is a heterocyclic nitrogenous base, which is found in the DNA and RNA. DNA has cytosine and thymine as pyrimidines, and RNA has uracil and cytosine has pyrimidines. It is a six-membered ring that contains two nitrogen atoms at 1 and 3 positions.
Answer to Problem 1P
Option (c), aspartate and carbamoyl phosphate.
Explanation of Solution
Reason for correct option:
Option (c) is aspartate and carbamoyl phosphate. Only two precursors, carbamoyl-P and aspartate are required for the formation of pyrimidine. For all the pyrimidines, only these two precursors are required. Hence, this option is correct.
Reasons for incorrect options:
Option (a) is glutamate and carbamoyl phosphate. Glutamate is the product of the reaction between carbamoyl-phosphate and glutamine amide. Aspartate is the main reactant for the production of pyrimidine. Hence, this option is incorrect.
Option (b) is aspartate and glutamine. Aspartate and glutamine are used in the production of purine and not for pyrimidine. Hence, this option is incorrect.
Option (d) is glycine and carbamoyl phosphate. Glycine is one of the main substrates used to produce purine. Hence, this option is incorrect.
Want to see more full solutions like this?
Chapter 25 Solutions
Biochemistry
- Biochemistry Question.For the metabolism of amino acids what is the first step for theirbreakdown? Why is it necessary for this breakdown product to be transported to the liver? For the catabolism of the carbon backbone of these amino acids, there are 7 entry points into the “standard” metabolic pathways. List these 7 entry points and which amino acids are metabolized to these entry points. Please help. Thank you!arrow_forwardBiochemistry Question. Please help. Thank you. You are studying pyruvate utilization in mammals for ATP production under aerobic conditions and have synthesized pyruvate with Carbon #1 labelled with radioactive C14. After only one complete cycle of the TCA cycle, which of the TCA cycle intermediates would be labeled with C14? Explain your answer. Interestingly, you find C14 being excreted in the urine. How does it get there?arrow_forwardBiochemistry question. Please help with. Thanks in advance For each of the enzymes listed below, explain what the enzyme does including function, names (or structures) of the substrate and products and the pathway(s) (if applicable) it is/are found in. (a) ATP synthetase (b) succinate dehydrogenase (c) isocitrate lyase (d) acetyl CoA carboxylase (e) isocitrate dehydrogenase (f) malate dehydrogenasearrow_forward
- Draw and name each alcohol and classify it as primary, secondary, or tertiary. Explain your answer thoroughly.arrow_forwardDraw the product of each reaction. If there are multiple products, draw only the major product. Explain your answer thoroughly.arrow_forwardIdentify the type of bond in the following disaccharides. Number your carbons to show work. Explain your answer thoroughly. Draw the number of carbons also.arrow_forward
- Draw and explain your answer thoroughly: a. What is the molar mass of aspirin (C9H8O4)?b. What is the mass of 0.00225mol of aspirin?c. How many moles of aspirin are present in 500mg of aspirin?arrow_forwardGeranylgeranyl pyrophosphate 5 is converted by general acid-base catalysis to 6, and then to the natural product 7. For clarity only limited atom numbers are shown, but the main chain carbons are numbered 1 to 16, and the off-chain methyl substituents are numbered 17-20. A. Based on what you specified in A, use curly arrows on the drawing above to convert 5 to 6, and 6 to 7. Invoke general acids and general bases as needed, and draw in hydrogens as necessary . B. On the structure of 7, write in the atom numbers for the carbons marked with an asteriskarrow_forwardα-Pinene (4) is synthesized enzymatically from nerol pyrophosphate 1. Drawn an arrow-pushing mechanism from 1 to 2 to 3 to 4; add explicit hydrogens to clarify, if needed.arrow_forward
- A reverse phase column chromatography separates proteins according to their polarity. Which pentapeptide will be eluted FIRST when chromatographed at pH 7 using a reverse phase column such as a C-18 column? Peptide Sequence (from N-terminal to C-terminal) AKGED GAAVF ALLLI MCYAG GAAVF MCYAG ALLLI AKGEDarrow_forwardMelting of three DNA samples with varying lengths was monitored by increase of ultraviolet light absorbance at 260 nm. Which is the shortest DNA? A B Carrow_forwardSelect the CORRECT description of the peptide bond. The peptide bond can freely rotate around the peptide bond. The peptide bond is non-polar, hydrophobic and does not have a dipole. The peptide bond is most stable in the cis configuration. The peptide bond is rigid and planar. The peptide bond has a mix of single and double bond characters. The peptide bond is most stable in the trans configuration.arrow_forward
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning