Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 25, Problem 10PDQ
List as many human traits as you can that are likely to be under the control of a polygenic mode of inheritance.
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Describe how traits can exhibit incomplete penetrance and vary in their expressivity.
What is polygenic inheritance? Discuss the issues that make polygenicinheritance difficult to study.
Which of the following defines polygenic inheritance?
An inheritance pattern in which one allele is not fully dominant over another, so the heterozygous phenotype is an intermediate blend of the two homozygous phenotypes
An inheritance pattern in which the full and separate phenotypic effects of two alleles are apparent in heterozygous individuals
An inheritance pattern in which a single gene affects multiple traits
A pattern of inheritance in which multiple genes affect one trait
Chapter 25 Solutions
Concepts of Genetics (12th Edition)
Ch. 25 - A homozygous plant with 20-cm-diameter flowers is...Ch. 25 - The following table shows measurements for fiber...Ch. 25 - The following cable gives the percentage of twin...Ch. 25 - At an interview with a genetic counselor, a couple...Ch. 25 - Prob. 2CSCh. 25 - At an interview with a genetic counselor, a couple...Ch. 25 - HOW DO WE KNOW? In this chapter, we focused on a...Ch. 25 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 25 - Define the following: (a) polygenic, (b) additive...Ch. 25 - A dark-red strain and a white strain of wheat are...
Ch. 25 - Height in humans depends on the additive action of...Ch. 25 - An inbred strain of plants has a mean height of 24...Ch. 25 - Erma and Harvey were a compatible barnyard pair,...Ch. 25 - In the following table, average differences of...Ch. 25 - What kind of heritability estimates (broad sense...Ch. 25 - List as many human traits as you can that are...Ch. 25 - Corn plants from a test plot are measured, and the...Ch. 25 - The following variances were calculated for two...Ch. 25 - The mean and variance of plant height of two...Ch. 25 - Prob. 14PDQCh. 25 - Prob. 15PDQCh. 25 - In an assessment of learning in Drosophila, flies...Ch. 25 - Prob. 17PDQCh. 25 - Prob. 18PDQCh. 25 - In a population of 100 inbred, genotypically...Ch. 25 - Many traits of economic or medical significance...Ch. 25 - A 3-inch plant was crossed with a 15-inch plant,...Ch. 25 - In a cross between a strain of large guinea pigs...Ch. 25 - Type A1B brachydactyly (short middle phalanges) is...Ch. 25 - In a series of crosses between two true-breeding...Ch. 25 - Students in a genetics laboratory began an...Ch. 25 - Prob. 26ESPCh. 25 - Canine hip dysplasia is a quantitative trait that...Ch. 25 - Floral traits in plants often play key roles in...Ch. 25 - In 1988, Horst Wilkens investigated blind...
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- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?arrow_forward
- A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?arrow_forwardsix small pedigrees are displayed. Indicate with J (yes) or N (No) if each pedigree is compatible with each of the following types of inheritance. Assume that the genetic characteristics are common in general population. Use table just like the table below in answering A B C D E F Autosomal Recessive Autosomal Dominant X-bound recessive X-bound dominant Y-Bottomarrow_forwardExplain the characteristics of polygenic and multifactorial traits.arrow_forward
- What is sickle cell anemia? What is the true inheritance pattern? How did scientists discover the true inheritance pattern? Explain multiple Alleles using Human Blood Groups as an example. Demonstrate the understanding of Polygenic Inheritance using an Example. (Skin colour or Height can be used as an example for explanation) . What is heterozygous advantage? Provide an example to explain the process.arrow_forwardDescribe how polygenic inheritance may result in a continuum of phenotypes.arrow_forwardA prospective father has two dominant traits dependent on single autosomal genes, cataract (an eye abnormality), which he inherited from his mother, and polydactyly (extra fingers and/or toes), which he inherited from his father. If the loci for these two traits are very closely linked, which of the following possibilities would the man's child be more likely to have (assume his partner is unaffected by either condition): Select one: either cataract or polydactyly both cataract and polydactyly neither traitarrow_forward
- Name: Human Phenotypes Simple dominance inheritance pattern: Q: How many phenotypes are evident in patterns of simple dominance? What are they? If a phenotype results from simple dominance, which two genotypes cannot be distinguished? Which phenotype is always representative of the genotype? Now determine your personal inheritance of the following traits. As you read through the following descriptions, you'll identify your trait, and determine your phenotype. Your trait will be one of the two Shape of the face. Most facial characteristics are affected by many different genes acting together (multiple factors or polygenic inheritance). For this trait we have simplified the nature of this trait by assuming it is the result of a single gene. Oval shape is dominant (needs only homozygous (both alleles are the same, either dominant or recessive) or heterozygous (one dominant allele and one recessive allele). Square shape is recessive (requires that both alleles are the recessive allele in…arrow_forwardPlease define the term “polygenic trait”. Please compare the polygenic traits with nonpolygenic traits. Please give examples of polygenic traits.arrow_forwardMatch the non-Mendelian genetic terms with their descriptor. Genetic and environmental factors collectively influence a phenotypic expression 1. Pleiotropy Two or more genes have a cumulative effect on a 2. Epitasis single phenotype 3. Polygenic Inheritance A single gene has more than one phenotypic effect 4. Multifactorial Effect A gene at one locus has an effect on a gene at another locusarrow_forward
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