The type of reaction which converts the structure B to ibuprofen in synthesis I has to be identified. Concept introduction: Malonic ester synthesis is used to prepare carboxylic acids of the desired length. The malonic ester reacts with an alkoxide base which removes a α hydrogen atom. The anion so formed is reacted with an alkyl bromide. Th anion abstracts the alkyl group from the alkyl bromide. Acidic hydrolysis of the intermediate so formed gives α − substituted malonic acid. On heating, decarboxylation takes place which gives the desired carboxylic acid .

Question

In the reaction of a nitrile with a Grignard reagent, there are two steps: a) nucleophilic addition of the Grignard to form an imine ion and b) hydrolysis of the imine to form a ketone. Draw the intermediate and the final product in this reaction. Ignore inorganic byproducts. 1. CH₂MgBr 2. H3O* Draw Imine Ion Intermediate 1. H30¹ 2. Neutralizing work-up a

Answer 1

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 19.9, Problem CQ

Interpretation Introduction

Interpretation:

The type of reaction which converts the structure B to ibuprofen in synthesis I has to be identified.

Concept introduction:

Malonic ester synthesis is used to prepare carboxylic acids of the desired length. The malonic ester reacts with an alkoxide base which removes a α hydrogen atom. The anion so formed is reacted with an alkyl bromide. Th anion abstracts the alkyl group from the alkyl bromide. Acidic hydrolysis of the intermediate so formed gives α−substituted malonic acid. On heating, decarboxylation takes place which gives the desired carboxylic acid.

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In the reaction of a nitrile with a Grignard reagent, there are two steps: a) nucleophilic addition of the Grignard to form an imine ion and b) hydrolysis of the imine to form a ketone. Draw the intermediate and the final product in this reaction. Ignore inorganic byproducts. 1. CH₂MgBr 2. H3O* Draw Imine Ion Intermediate 1. H30¹ 2. Neutralizing work-up a

6. Multi Step Synthesis. Propose a synthetic route from the reactant to the product using any reagents you need. Nalt LINH4

Choose all correct statements. 1. Gilman reagents react with alkyl halides, including vinyl and aryl halides. 2. Grignard reagents react with alkyl halides, including vinyl and aryl halides. 3. Deprotonation of an alcohol group forms an oxonium intermediate. 4. Whenever a neutral nucleophile attacks, a proton transfer step follows. 5. An alcohol that is chiral at the a-carbon will undergo inversion of absolute configuration when it is converted into an alkyl tosylate. C 1 2 3 4

Answer 2

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 19.9, Problem CQ

Interpretation Introduction

Interpretation:

The type of reaction which converts the structure B to ibuprofen in synthesis I has to be identified.

Concept introduction:

Malonic ester synthesis is used to prepare carboxylic acids of the desired length. The malonic ester reacts with an alkoxide base which removes a α hydrogen atom. The anion so formed is reacted with an alkyl bromide. Th anion abstracts the alkyl group from the alkyl bromide. Acidic hydrolysis of the intermediate so formed gives α−substituted malonic acid. On heating, decarboxylation takes place which gives the desired carboxylic acid.

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Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 19.9, Problem CQ

Interpretation Introduction

Interpretation:

The type of reaction which converts the structure B to ibuprofen in synthesis I has to be identified.

Concept introduction:

Malonic ester synthesis is used to prepare carboxylic acids of the desired length. The malonic ester reacts with an alkoxide base which removes a α hydrogen atom. The anion so formed is reacted with an alkyl bromide. Th anion abstracts the alkyl group from the alkyl bromide. Acidic hydrolysis of the intermediate so formed gives α−substituted malonic acid. On heating, decarboxylation takes place which gives the desired carboxylic acid.

Expert Solution & Answer

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Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 19.9, Problem CQ

Interpretation Introduction