The total synthesis of the anticholinergic drug, the structure formulas for the intermediates has to be proposed. Concept introduction: Michael reaction: In 1, 4 addition the Nucleophile is added to the carbon β to the carbonyl while the hydrogen is added to the carbon α to the carbonyl. Dieckann Condensation The base-catalyzed intramolecular condensation of a diester. The Dieckmann Condensation works well to produce 5- or 6-membered cyclic β -keto esters, and is usually affected with sodium alkoxide in alcoholic solvent. Sodium borohydride is reducing agent, generally aldehyde and ketone reduced to alcohol.

Question

Identify A, B, and C, three intermediates in the synthesis of the pain reliever and anesthetic fentanyl.

Answer 1

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19, Problem 19.49P

Interpretation Introduction

Interpretation:

The total synthesis of the anticholinergic drug, the structure formulas for the intermediates has to be proposed.

Concept introduction:

Michael reaction:

In 1, 4 addition the Nucleophile is added to the carbon β to the carbonyl while the hydrogen is added to the carbon α to the carbonyl.

Dieckann Condensation

The base-catalyzed intramolecular condensation of a diester. The Dieckmann Condensation works well to produce 5- or 6-membered cyclic β-keto esters, and is usually affected with sodium alkoxide in alcoholic solvent.

Sodium borohydride is reducing agent, generally aldehyde and ketone reduced to alcohol.

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Identify A, B, and C, three intermediates in the synthesis of the pain reliever and anesthetic fentanyl.

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Answer 2

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19, Problem 19.49P

Interpretation Introduction

Interpretation:

The total synthesis of the anticholinergic drug, the structure formulas for the intermediates has to be proposed.

Concept introduction:

Michael reaction:

In 1, 4 addition the Nucleophile is added to the carbon β to the carbonyl while the hydrogen is added to the carbon α to the carbonyl.

Dieckann Condensation

The base-catalyzed intramolecular condensation of a diester. The Dieckmann Condensation works well to produce 5- or 6-membered cyclic β-keto esters, and is usually affected with sodium alkoxide in alcoholic solvent.

Sodium borohydride is reducing agent, generally aldehyde and ketone reduced to alcohol.

Expert Solution & Answer

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See solution

Check out sample textbook solution

Answer 3

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19, Problem 19.49P

Interpretation Introduction

Interpretation:

The total synthesis of the anticholinergic drug, the structure formulas for the intermediates has to be proposed.

Concept introduction:

Michael reaction:

In 1, 4 addition the Nucleophile is added to the carbon β to the carbonyl while the hydrogen is added to the carbon α to the carbonyl.

Dieckann Condensation

The base-catalyzed intramolecular condensation of a diester. The Dieckmann Condensation works well to produce 5- or 6-membered cyclic β-keto esters, and is usually affected with sodium alkoxide in alcoholic solvent.

Sodium borohydride is reducing agent, generally aldehyde and ketone reduced to alcohol.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19, Problem 19.49P

Interpretation Introduction