Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Question
Chapter 19, Problem 20PDQ
Summary Introduction
To determine: The relationship between methylation of the glucocorticoid receptor gene and behavioral response to stress.
Introduction: Stress refers to a state or tension. It can be both positive and negative. If stress motivates an individual and enhances his performance, then it is positive. When stress deteriorates the individual’s performance, then it is negative.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Through recombinant DNA methods, a modified steroid hormone receptor was prepared that consists of an estrogen receptor with its ligand-binding domain replaced by the ligandbinding domain from the progesterone receptor. Predict the expected responsiveness of gene expression for cells treated with estrogen or with progesterone.
Many currently marketed drugs exert their pharmacological effects by binding to ligand-activated transcription factors and modulating gene expression. One example, are various drugs that target the estrogen receptor to treat breast cancer, osteoporosis and post-menopausal symptoms. Below is a ChIP experiment examining the effects of no drug treatment (C), the natural hormone estrogen (E) and the drugs tamoxifen (T) and raloxifene (R) on recruitment of coactivators (SRC-1 and CBP), Histone Deacetylase Complexes (HDACs) and acetylation of histones associated with the C-myc gene. Which of the following statements are correct based on this data (select all that apply)?
Identify the two general functions of the proteins encoded bytumor-suppressor genes.
Chapter 19 Solutions
Concepts of Genetics (12th Edition)
Ch. 19 - Although histone modifications can activate or...Ch. 19 - Prob. 2NSTCh. 19 - Prob. 1CSCh. 19 - Prob. 2CSCh. 19 - A couple well informed about the epigenetic...Ch. 19 - Prob. 1PDQCh. 19 - Prob. 2PDQCh. 19 - Prob. 3PDQCh. 19 - Prob. 4PDQCh. 19 - Prob. 5PDQ
Ch. 19 - Prob. 6PDQCh. 19 - Prob. 7PDQCh. 19 - Prob. 8PDQCh. 19 - Prob. 9PDQCh. 19 - Prob. 10PDQCh. 19 - What are the functions of IncRNAs in epigenetic...Ch. 19 - Prob. 12PDQCh. 19 - What are the differences and similarities among...Ch. 19 - Prob. 14PDQCh. 19 - Prob. 15PDQCh. 19 - Should fertility clinics be required by law to...Ch. 19 - Prob. 17PDQCh. 19 - Prob. 18PDQCh. 19 - A developmental disorder in humans called spina...Ch. 19 - Prob. 20PDQCh. 19 - PraderWilli syndrome (PWS) is a genetic disorder...Ch. 19 - Prob. 22ESPCh. 19 - Prob. 23ESPCh. 19 - Methylation of H3K9 by itself silences genes, but...
Knowledge Booster
Similar questions
- Describe the steps that need to occur for the glucocorticoid receptor to bind to a GRE.arrow_forwardGC (Glycocorticoids) binds to the glucocorticoid receptor (GR), which leads to the transcription of a series of genes (PC, PCK1, FBP1, PFKFB1, G6PC and G6P transporter (SLC37A4)) involved in gluconeogenesis. What type of receptor is GR? Where would you expect the activated GR to be located to enhance the expression of the gluconeogenic genes? Which cis-acting elements are used by GR as an activator to turn gene transcription “on”?arrow_forwardIdentify the mechanisms of transcriptional,posttranscriptional, and translational control of geneexpression.arrow_forward
- Mutations were introduced into a type I receptor of steroid hormone X. Two classes of mutants were obtained. Class I mutants were severely defective in receptor-HSP (heat shock protein) interaction and class II mutants could not form receptor dimers. What effect the two classes of mutations will have on expression of genes controlled by hormone X?arrow_forwardGive and briefly explain two examples of how gene expression may be repressed without altering the gene-coding sequence.arrow_forwardOutline the steps whereby glucocorticoid receptors and CREB proteins regulate genes.arrow_forward
- Name three genes whose mutations lead to an altered behavioral phenotype. Briefly describe the normal function of the mutated gene as well as the altered phenotype.arrow_forwardDescribe Duchenne muscular dystrophy (DMD) including its cause and symptoms. Then, explain why DMD is expressed in males while females tend to be gene mutation carriers.arrow_forwardWhich mechanisms for regulating gene expression may be applied for the treatment of such diseases? Propose a method of treatment. Explain how it might work. Reference: https://link.springer.com/article/10.1186/ar3317arrow_forward
- The melatonin receptor exists in different isoforms: MT1, encoded by MT-1 gene and MT2, encoded by MT-2 gene. The following is the sequence corresponding to 90-140 base pairs (bp) of MT-1 and MT-2 genes. Which of the following statements are true for these DNA sequences. Select all that apply. 90 140 MT-1: 5'------GATATGCCCCCCCCGGCGCGCGATATGCCCCCCCCGGCGCGCGTGCGTGA -3' 3'------CTATACGGGGGGGGCCGCGCGCTATACGGGGGGGGCCGCGCGCACGCACT- -5' 90 140 ---GATATGATATATATATATATAGATATGAAAAATTTTTATATAGTGCGTGA- MT-2: 5' ---3' 3'-----CTATACTATATATATATATATCTATACTTTTTAAAAAATTATCACGCACT-- ----5' MT-2 will denature at a higher temperature than MT-1 1 MT-2 will denature at a lower temperature than MT-1 MT-1 will denature at a higher temperature than MT-2 MT-1 will denature at a lower temperature than MT-2arrow_forwardWhat is the structural difference between normal EGFR and oncogenic receptor, e.g. ERbB? How does it affect its activity?arrow_forwardSuggest and explain one way epigenetics may affect the age when symptoms of Huntington's disease start.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning