Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 19, Problem 19PDQ
A developmental disorder in humans called spina bifida is a neural tube defect linked to a maternal diet low in folate during pregnancy.
- (a) What does this suggest about the cause of spina bifida?
- (b) Does this exclude genetic mutations as a cause of this condition?
- (c) Should researchers be looking for mutant alleles of genes that control formation and differentiation of the neural tube?
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Students have asked these similar questions
the ectoderm of a gastrula stage vertebrate embryo, what is the major function of BMP4?
a). repress nervous system development
b). repress skin development
c). promote nervous system development
d). promote the onset of gastrulation
e). More than one of the above are correct.
2. Which is an essential characteristic of neural stem cells?
a) The ability to differentiate into any type of cell
b) The ability to dispense with bacteria, damaged neuron, or toxic proteins in the brain
c) The ability to guide neurons to their final location
d) The ability to suppress the activity of the immune system
e) The ability to differentiate into any cell type found in the central nervous system
Zygote
Embryo
Muscle cells
Intestinal cells
Liver cells
Blood cells
Nerve cell
Cardiac cells
(1) Specialization occurs, resulting in the
formation of a great variety of cell types.
(2) Genes are inserted into the zygote to
allow for the formation of different cell
types.
(3) The expression of genes responsible for
the different cell types is controlled by the
placenta.
(4) The genetic information in the zygote is
divided to produce a complete set for each
cell type
Cancer-causing mutations in genes can have different effects on the protein products expressed. a) What type of mutation would be dominant in the development of cancer? Why? b) What type of mutation would be expressed as a recessive trait in the development of cancer? Why? c) Based upon your answers to parts (a) and (b), how would you treat these situations using a gene therapy approach?
Chapter 19 Solutions
Concepts of Genetics (12th Edition)
Ch. 19 - Although histone modifications can activate or...Ch. 19 - Prob. 2NSTCh. 19 - Prob. 1CSCh. 19 - Prob. 2CSCh. 19 - A couple well informed about the epigenetic...Ch. 19 - Prob. 1PDQCh. 19 - Prob. 2PDQCh. 19 - Prob. 3PDQCh. 19 - Prob. 4PDQCh. 19 - Prob. 5PDQ
Ch. 19 - Prob. 6PDQCh. 19 - Prob. 7PDQCh. 19 - Prob. 8PDQCh. 19 - Prob. 9PDQCh. 19 - Prob. 10PDQCh. 19 - What are the functions of IncRNAs in epigenetic...Ch. 19 - Prob. 12PDQCh. 19 - What are the differences and similarities among...Ch. 19 - Prob. 14PDQCh. 19 - Prob. 15PDQCh. 19 - Should fertility clinics be required by law to...Ch. 19 - Prob. 17PDQCh. 19 - Prob. 18PDQCh. 19 - A developmental disorder in humans called spina...Ch. 19 - Prob. 20PDQCh. 19 - PraderWilli syndrome (PWS) is a genetic disorder...Ch. 19 - Prob. 22ESPCh. 19 - Prob. 23ESPCh. 19 - Methylation of H3K9 by itself silences genes, but...
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- Neurofibromatosis type 1 (NF1) is an inherited is an inheritent dominant disorder. The phenotype usually involves the production of many skin neurofibromas. Answer the following questions about the disorder: a) Are the NF1 neurofibromatosis-causing mutations that are inherited by affected children from affected parents likely to be loss-of-function or gain-of-function mutations? b) Neurofibromin, the protein product of NF1, is associated with the Ras protein. Ras is involved in the transduction of extracellular signals from growth factors. The active form of Ras is complexed with GTP; the inactive form is complexed with GDP. Would the wild-type neurofibromin protein favor the formation of Ras-GTP or Ras-GDP? c) Which of the following events in a normal cell from an individual inheriting a neurofibromatosis-causing allele could cause the descendents of that cell to turn into a neurofibroma? i. A second point mutation in…arrow_forwardOne of the key components in vertebrate limb development is the polarizing region, also known as the zone or polarizing activituy of ZPA. a) Where in the limb bud is this region? b) What axis of the limb does it help to specify? c) What properties of this region make it an organizing region d) Through which signaling molecule does it exert its effects? e) What is the evidence for the importance of this molecule?arrow_forwardThe phenotype of a heterozygous mouse (Aa) is agouti. The agouti banding pattern is due to altered expression of the agouti gene. Which of the following statement is false? a) Expression of the agouti gene inhibits the production of eumelanin. b) Evidence suggests that the agouti gene is only expressed in tissues associated with fur production. c) Epigenetic markers silence the agouti gene resulting in dark pigmentation at the tip and root of the hair. d) All of the abovearrow_forward
- a 1-hour old male newborn has an open calvaria with absence of the cerebral hemispheres and a cerebellum with a residual brain stem. there are protruding eyes, muscle hypotonia and bilateral club feet . which of the following developmental processes is most likely affected in This newborn .A) axis specification ,B) closure of the caudal neuropore, C) closure of the rostral neuropore,D) development of the apical ectodermal ridge. E) development of the notochord, F) development of the zone of polarizing activity . G) polarity specification , H) scheduled apoptoarrow_forwardMany oncogenes result from mutations that cause excessive expression of a protein in cells where it is normally not expressed or is expressed at inappropriate times during development. This type of mutation can be described as ________. A) amorphic B) hypomorphic C)hypermorphic D) neomorphic E) dominant negativearrow_forward(a) How does the duplication of individual genes occur? (b) individual that inherit a genetic condition known as xeroderma pigmentosum exhibit an extreme sensitivity to sunlight exposure and often develop skin cancer by the age of 10. What repair pathway is most likely disrupted as a result of such mutation? Explain why?arrow_forward
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