Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 18, Problem 6PDQ
Explain how a tissue-specific RNA-binding protein can lead to tissue-specific alternative splicing via splicing enhancers or splicing silencers.
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Chapter 18 Solutions
Concepts of Genetics (12th Edition)
Ch. 18 - Some mutations in the tra gene of Drosophila cause...Ch. 18 - Some scientists use the analogy that the...Ch. 18 - Consider the example that actin mRNA localization...Ch. 18 - What is alternative splicing, where does it occur,...Ch. 18 - What role might the expanded tri- and...Ch. 18 - DM1 is characterized by a phenomenon known as...Ch. 18 - HOW DO WE KNOW? In this chapter, we focused on how...Ch. 18 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 18 - List three types of alternative splicing patterns...Ch. 18 - Consider the CT/CGRP example of alternative...
Ch. 18 - Explain how the use of alternative promoters and...Ch. 18 - Explain how a tissue-specific RNA-binding protein...Ch. 18 - The regulation of mRNA decay relies heavily upon...Ch. 18 - Nonsense-mediated decay is an mRNA surveillance...Ch. 18 - AU-rich elements (AREs) are cis-elements in mRNAs...Ch. 18 - What are processing bodies (P bodies), and what...Ch. 18 - In 1998, future Nobel laureates Andrew Fire and...Ch. 18 - Present an overview of RNA interference (RNAi)....Ch. 18 - RNAi may be directed by small interfering RNAs...Ch. 18 - Prob. 14PDQCh. 18 - In principle, RNAi may be used to fight viral...Ch. 18 - Prob. 16PDQCh. 18 - Prob. 17PDQCh. 18 - Prob. 18PDQCh. 18 - Prob. 19PDQCh. 18 - How is it possible that a given mRNA in a cell is...Ch. 18 - Prob. 21PDQCh. 18 - Prob. 22PDQCh. 18 - Prob. 23PDQCh. 18 - Prob. 24ESPCh. 18 - Prob. 25ESPCh. 18 - Mutations in the low-density lipoprotein receptor...Ch. 18 - RNA helicases are a class of proteins that bind...Ch. 18 - While miRNA response elements (MREs) may be...Ch. 18 - RNAi is currently being tested as a therapeutic...Ch. 18 - The localization and translational control of...Ch. 18 - Explain how the expression of a single gene can be...
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- Outline a mechanism by which RNA can catalyze its own self-splicing.arrow_forwardExplain how self splicing occurs. Don't specify the base sequence of 5 prime and 3 prime splice sites. Only overall of how self splicing occurs.arrow_forwardComparison of different tissues shows that the ITY gene produces a 900 nt mature mRNA and a 190 amino acid long protein in peripheral nerves, but in another tissue, the same gene produces a 720 nt long mRNA and a larger protein, 130 amino acid long. This is a result of alternative splicing. a. For this difference to result from alternative splicing, does there need to be a difference in the DNA sequence between the ITY gene in the peripheral nerves, and the ITY gene in the other tissue? Yes Explain your reasoning: No b. If an entire exon is included in one tissue, and excluded in the other, what is the length, in nucleotides, of the alternatively-spliced exon? c. Which part(s) of the protein have difference sequences in the two types of nerves, the N- terminus, C-terminus, or middle of the protein? i. N-terminus ii. C-terminus iii. Somewhere in the middle of the proteinarrow_forward
- Draw the SMN2 mature mRNA before treatment with Spinraza. What type of alternative splicing is occurring?arrow_forwardResults of dsx splicing when tra is present?arrow_forwardPlease compare the effect of an active enhancer at the level of RNA transcription with the effect of an active enhancer at the level of RNA splicingarrow_forward
- Explain how the expression of a single gene can be quickly,efficiently,and specifically shut down at the transcriptional,posttranscriptional,and posttranslational stages through thecoordinated expression of a transcriptional repressor, an miRNA,and a ubiquitin ligase.arrow_forwardSex determination in Drosophila is controlled by a cascade of alternative splicing events. Sex-lethal (Sxl) is involved in regulating splicing of the transformer gene, as outlined below (picture attached). According to this schematic, Sxl functions as a: Splicing enhancer Splicing repressor Splicing activator Splicing silencerarrow_forwardSplicing machinery must recognize three portions of the precursor RNA molecule: the 5’ splice site, the 3’ splice site, and the exon junction complex (EJC). True or falsearrow_forward
- Discuss how the expression of a protein can be regulated post transcription in eukaryotic cells through, using the following key terms: Degradation of mRNA (two ways) Blocking translation Degradation of the proteinarrow_forwardSplicing regulatory (SR) proteins bind at exon to recruit U1snRNP and U2 SNRNP during RNA splicing. * True falsearrow_forwardDescribe how mature messenger ribonucleic acids (MRNAS) are post-transcriptionally processed in the nucleus before they are transported to the cytoplasm of a eukaryotic cell.arrow_forward
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