The effect of changes in splicing on RNAs and function of a tumor-suppressor gene. Introduction: The splicing of RNA refers to a method of RNA processing where a precursor messenger RNA gets transformed into a mature messenger RNA. The process of splicing excise introns from the exons during the process of splicing.

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Chapter 18, Problem 25ESP

Summary Introduction

To determine: The effect of changes in splicing on RNAs and function of a tumor-suppressor gene.

Introduction: The splicing of RNA refers to a method of RNA processing where a precursor messenger RNA gets transformed into a mature messenger RNA. The process of splicing excise introns from the exons during the process of splicing.

Summary Introduction

To determine: The ways by which the loss of splicing specificity can be associated with cancer.

Introduction: During the process of splicing the removal of introns from the pre-mRNA occurs, whereas the exons remain together and form mature mRNA. The encoding of the protein is only done by the exons.

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Comparison of different tissues shows that the ITY gene produces a 900 nt mature mRNA and a 190 amino acid long protein in peripheral nerves, but in another tissue, the same gene produces a 720 nt long mRNA and a larger protein, 130 amino acid long. This is a result of alternative splicing. a. For this difference to result from alternative splicing, does there need to be a difference in the DNA sequence between the ITY gene in the peripheral nerves, and the ITY gene in the other tissue? Yes Explain your reasoning: No b. If an entire exon is included in one tissue, and excluded in the other, what is the length, in nucleotides, of the alternatively-spliced exon? c. Which part(s) of the protein have difference sequences in the two types of nerves, the N- terminus, C-terminus, or middle of the protein? i. N-terminus ii. C-terminus iii. Somewhere in the middle of the protein

siRNAs are used to “knockdown” gene expression in research. Imagine you are a scientist who hopes to study several genes related to cancer. Select all the scenarios you will be able to successfully use RNA interference with the use of siRNAs (select all that apply): Group of answer choices Regulate transcript levels by targeting the siRNA to core promoter regions (e.g. TATA box) of tumor suppressor genes Regulate transcript levels by targeting the siRNA to the regulatory promoter regions (e.g. enhancers) of tumor suppressor genes Regulate transcript levels by targeting the siRNA to any region of the processed mRNA Regulate transcript levels by targeting the siRNA to the 5’ UTR of the processed mRNA Regulate transcript levels by targeting the siRNA to the 3’ UTR of the processed mRNA Regulate transcript levels by targeting the siRNA to sites where the histone acetyl transferase will acetylate the histones Regulate transcript levels by targeting the siRNA to where the start…

Several research studies are under way that involve the use of genetherapies to inhibit the growth of cancer cells. Oncogenes are mutant genes that are overexpressed and cause cancer. New gene therapies are aimed at silencing oncogenes by producing antisense RNA that recognizes the mRNAtranscribed from oncogenes. Based on your understanding of antisense RNA , explain how this strategy would prevent the growth of cancer cells.

Answer 2

Question

Chapter 18, Problem 25ESP

Summary Introduction

To determine: The effect of changes in splicing on RNAs and function of a tumor-suppressor gene.

Introduction: The splicing of RNA refers to a method of RNA processing where a precursor messenger RNA gets transformed into a mature messenger RNA. The process of splicing excise introns from the exons during the process of splicing.

Summary Introduction

To determine: The ways by which the loss of splicing specificity can be associated with cancer.

Introduction: During the process of splicing the removal of introns from the pre-mRNA occurs, whereas the exons remain together and form mature mRNA. The encoding of the protein is only done by the exons.

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Answer 3

Question

Chapter 18, Problem 25ESP

Summary Introduction

To determine: The effect of changes in splicing on RNAs and function of a tumor-suppressor gene.

Introduction: The splicing of RNA refers to a method of RNA processing where a precursor messenger RNA gets transformed into a mature messenger RNA. The process of splicing excise introns from the exons during the process of splicing.

Summary Introduction

To determine: The ways by which the loss of splicing specificity can be associated with cancer.

Introduction: During the process of splicing the removal of introns from the pre-mRNA occurs, whereas the exons remain together and form mature mRNA. The encoding of the protein is only done by the exons.

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Answer 4

Question

Chapter 18, Problem 25ESP

Summary Introduction

To determine: The effect of changes in splicing on RNAs and function of a tumor-suppressor gene.

Introduction: The splicing of RNA refers to a method of RNA processing where a precursor messenger RNA gets transformed into a mature messenger RNA. The process of splicing excise introns from the exons during the process of splicing.

Summary Introduction

To determine: The ways by which the loss of splicing specificity can be associated with cancer.

Introduction: During the process of splicing the removal of introns from the pre-mRNA occurs, whereas the exons remain together and form mature mRNA. The encoding of the protein is only done by the exons.

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Answer 5

Chapter 18, Problem 25ESP

Summary Introduction

To determine: The effect of changes in splicing on RNAs and function of a tumor-suppressor gene.

Introduction: The splicing of RNA refers to a method of RNA processing where a precursor messenger RNA gets transformed into a mature messenger RNA. The process of splicing excise introns from the exons during the process of splicing.

Summary Introduction

To determine: The ways by which the loss of splicing specificity can be associated with cancer.

Introduction: During the process of splicing the removal of introns from the pre-mRNA occurs, whereas the exons remain together and form mature mRNA. The encoding of the protein is only done by the exons.

Answer 6

Chapter 18, Problem 25ESP

Summary Introduction

To determine: The effect of changes in splicing on RNAs and function of a tumor-suppressor gene.

Introduction: The splicing of RNA refers to a method of RNA processing where a precursor messenger RNA gets transformed into a mature messenger RNA. The process of splicing excise introns from the exons during the process of splicing.

Answer 7

Chapter 18, Problem 25ESP

Summary Introduction

To determine: The effect of changes in splicing on RNAs and function of a tumor-suppressor gene.

Introduction: The splicing of RNA refers to a method of RNA processing where a precursor messenger RNA gets transformed into a mature messenger RNA. The process of splicing excise introns from the exons during the process of splicing.

Answer 8

Summary Introduction

To determine: The ways by which the loss of splicing specificity can be associated with cancer.

Introduction: During the process of splicing the removal of introns from the pre-mRNA occurs, whereas the exons remain together and form mature mRNA. The encoding of the protein is only done by the exons.

Answer 9

Summary Introduction

To determine: The ways by which the loss of splicing specificity can be associated with cancer.

Introduction: During the process of splicing the removal of introns from the pre-mRNA occurs, whereas the exons remain together and form mature mRNA. The encoding of the protein is only done by the exons.

Answer 10

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Solution Summary: The author explains the effects of changes in splicing on RNAs and the function of a tumor-suppressor gene.

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