Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 18, Problem 23PDQ
Summary Introduction
To determine: The way by which proteasome regulates the degradation of certain proteins.
Introduction: The proteasomes are the protein complexes that degrade the damaged proteins by the process called proteolysis. Proteolysis is a
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Chapter 18 Solutions
Concepts of Genetics (12th Edition)
Ch. 18 - Some mutations in the tra gene of Drosophila cause...Ch. 18 - Some scientists use the analogy that the...Ch. 18 - Consider the example that actin mRNA localization...Ch. 18 - What is alternative splicing, where does it occur,...Ch. 18 - What role might the expanded tri- and...Ch. 18 - DM1 is characterized by a phenomenon known as...Ch. 18 - HOW DO WE KNOW? In this chapter, we focused on how...Ch. 18 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 18 - List three types of alternative splicing patterns...Ch. 18 - Consider the CT/CGRP example of alternative...
Ch. 18 - Explain how the use of alternative promoters and...Ch. 18 - Explain how a tissue-specific RNA-binding protein...Ch. 18 - The regulation of mRNA decay relies heavily upon...Ch. 18 - Nonsense-mediated decay is an mRNA surveillance...Ch. 18 - AU-rich elements (AREs) are cis-elements in mRNAs...Ch. 18 - What are processing bodies (P bodies), and what...Ch. 18 - In 1998, future Nobel laureates Andrew Fire and...Ch. 18 - Present an overview of RNA interference (RNAi)....Ch. 18 - RNAi may be directed by small interfering RNAs...Ch. 18 - Prob. 14PDQCh. 18 - In principle, RNAi may be used to fight viral...Ch. 18 - Prob. 16PDQCh. 18 - Prob. 17PDQCh. 18 - Prob. 18PDQCh. 18 - Prob. 19PDQCh. 18 - How is it possible that a given mRNA in a cell is...Ch. 18 - Prob. 21PDQCh. 18 - Prob. 22PDQCh. 18 - Prob. 23PDQCh. 18 - Prob. 24ESPCh. 18 - Prob. 25ESPCh. 18 - Mutations in the low-density lipoprotein receptor...Ch. 18 - RNA helicases are a class of proteins that bind...Ch. 18 - While miRNA response elements (MREs) may be...Ch. 18 - RNAi is currently being tested as a therapeutic...Ch. 18 - The localization and translational control of...Ch. 18 - Explain how the expression of a single gene can be...
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- Define, explain, and differentiate between, the processes of transcription and translation. What enzymes or sub-cellular structures are responsible for carrying out these processes?arrow_forwardIn a given sample (whole organism, tissue, cell, subcellular compartment), what fraction of the whole proteome is expressed (i.e., which proteins are present)?arrow_forwardWhich enzymes catalyze the chain elongation steps during replication, transcription and translation, respectively?arrow_forward
- Why is it important to put regulatory mechanisms in place at specific portions of the pathway from DNA to protein?arrow_forwardwhat is post-translational protein covalent modification? give three examples and name the enzyme that catalyzes each reaction.arrow_forwardWhich of the following components of the ubiqutin-proteasome pathway are ATPases? (i.e., which consume ATP in order to function?) (Select all that apply) a)E3 ubiquitin-protein ligase b)19S proteasome c)20S proteasome d)E2 ubiquitin-conjugating enzyme e)E1 ubiquitin-activating enzyme f)Ubiquitinarrow_forward
- Describe regulatory mechanisms for each of the following levels. Give at least on example for each level: (1) DNA, (2) transcription, (3) translation, and (4) post-translationarrow_forwardList three potential organelle destinations for a free ribosome (cytosolic-produced) protein via transmembrane protein translocation:arrow_forwardAn enthusiastic student, learning that proteasomes degrade proteins, suggests using a proteasome inhibitor drug to increase human longevity. The rationale given was that degradation wastes the energy that the cell put into to synthesizing those proteins in the first place, and avoiding that waste of energy would lead to increased protein accumulation, growth, and, perhaps, life span. Is this a theoretically sound approach to increasing lifespan ? Only one answer is correct. Question 1 options: yes, conserving energy by reducing protein degradation would be beneficial to the organism, so a proteasome inhibitor should increase lifespan. yes, because inhibition of the proteasome would lead to were non-functional then poly-ubiquitin chains would likely be retained on ubiquitin ligase-targeted proteins and this additional protein mass would contribute further to growth. no, because protein degradation through the proteasome…arrow_forward
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