BIOLOGY
BIOLOGY
12th Edition
ISBN: 9781260169614
Author: Raven
Publisher: RENT MCG
bartleby

Concept explainers

bartleby

Videos

Textbook Question
Book Icon
Chapter 17, Problem 2S

Amyloid beta is a proteolytic product of a protein found in the brain called amyloid precursor protein (APP). At high concentrations, amyloid beta clumps together and may be a cause of Alzheimer disease. How might you go about studying, in a mouse model, whether particular mutations maintained the normal function of APP, while preventing clumping of the amyloid beta derived from APP?

Blurred answer
Students have asked these similar questions
For each of the following situations, provide a plausible explanation for how it could lead to unrestricted cell division.(a) Colon cancer cells often contain mutations in the gene encoding the prostaglandin E2 receptor. PGE2 is a growth factor required for the division of cells in the gastrointestinal tract.(b) Kaposi sarcoma, a common tumor in people with untreated AIDS, is caused by a virus carrying a gene for a protein similar to the chemokine receptors CXCR1 and CXCR2. Chemokines are cell-specific growth factors.(c) Adenovirus, a tumor virus, carries a gene for the protein E1A, which binds to the retinoblastoma protein, pRb. (d) An important feature of many oncogenes and tumor suppressor genes is their celltype specificity. For example, mutations in the PGE2 receptor are not typically found in lung tumors. Explain this observation. (Note that PGE2 acts through a GPCR in the plasma membrane.)
When an injury occurs to the skin, the epithelial cells near the wound are signaled to react (by proliferating, migrating, and/or differentiating) to restore the skin in the wound.  To investigate the healing process, researchers removed a small area of epithelial cells from the skin of mice, causing a wound.  The researchers monitored the acetylation status of histone H4 at lysines K5, K8, and K16 on days 1, 4 and 9 after the wound was made.  Cells in three regions were studied (see Figure A below): Normal epithelial cells not directly near the wound Epithelial cells adjacent to the wound The cells repopulating/repairing the wound (referred to as an “epithelial tongue” early in the process and “closed wound” later in the process)     The percent of cells that were positive for H4 acetylation was recorded.  The bar graph in Figure B below shows data for Days 4 and 9 for cells examined in the wound.       While this experiment focused on mice, we may be able to apply the results to…
The codon change (Gly-12 to Val-12) in human rasH that convertsit to oncogenic rasH has been associated with many types ofcancers. For this reason, researchers would like to develop drugs toinhibit oncogenic rasH. Based on your understanding of the Rasprotein, what types of drugs might you develop? In other words,what would be the structure of the drugs, and how would theyinhibit Ras protein? How would you test the efficacy of the drugs?What might be some side effects?
Knowledge Booster
Background pattern image
Biology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Text book image
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Text book image
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Text book image
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
Information Storage and the Brain: Learning and Memory; Author: Professor Dave Explains;https://www.youtube.com/watch?v=PQDiUKwXLVI;License: Standard youtube license