Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 16, Problem 9P
When the identical subunits of chicken liver fatty acid synthase are dissociated in vitro, all of the activities can be detected in the separated subunits except for the ß-ketoacyl synthase reaction and the overall synthesis of palmitate. Explain these observations.
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When the identical subunits of chicken liver fatty acid synthase are dissociated in vitro, all of the activities can be detected in the separated subunits except for the β-ketoacyl synthase reaction and the overall synthesis of palmitate. Explain these observations.
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Describe these reactions using the degradation of palmitic acid as an example.
Chapter 16 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
Ch. 16 - Prob. 1PCh. 16 - If palmitic acid is subjected to complete...Ch. 16 - Calculate the number of ATPs generated by the...Ch. 16 - Prob. 4PCh. 16 - Prob. 5PCh. 16 - Under conditions where ketone bodies are being...Ch. 16 - Prob. 7PCh. 16 - 2-Bromopalmitoyl-CoA inhibits the oxidation of...Ch. 16 - When the identical subunits of chicken liver fatty...Ch. 16 - Prob. 10P
Ch. 16 - Prob. 11PCh. 16 - Prob. 12PCh. 16 - Prob. 13PCh. 16 - Prob. 14PCh. 16 - Prob. 15PCh. 16 - What would be the effect on fatty acid synthesis...Ch. 16 - Prob. 17PCh. 16 - Identify and briefly discuss each mechanism...Ch. 16 - Prob. 19PCh. 16 - Prob. 20PCh. 16 - Prob. 21PCh. 16 - Prob. 22PCh. 16 - Prob. 23PCh. 16 - 24. If mevalonate labeled with 14C in the carboxyl...Ch. 16 - Prob. 25PCh. 16 - Identify a pathway for utilization of the four...Ch. 16 - Prob. 27PCh. 16 - cis-Vaccenate is an 18-carbon unsaturated fatty...Ch. 16 - 29. Briefly describe how cyclic AMP controls...Ch. 16 - Prob. 30PCh. 16 - Prob. 31PCh. 16 - In addition to the pathway described in Figure...Ch. 16 - Prob. 33P
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- The products of pyrimidine base catabolism, β-alanine and β-aminoisobutyrate, can be further degraded to acetyl-CoA and succinyl-CoA, respectively. Can you suggest the types of reaction required to accomplish these transformations?arrow_forwardIs it true that beta-ketoacyl-ACP-reductase catalyzes the committed stepn in fatty acid biosynthesis?arrow_forwardWith fatty infiltration of the liver, the synthesis of phospholipids is disturbed. What is the biochemical basis of the development of such a condition? What are its possible nests? Justify the answer.arrow_forward
- Thiolase is homologous in structure to the condensing enzyme. On the basis of this observation, propose a mechanism for the cleavage of 3-ketoacyl CoA by CoA.arrow_forwardA sample of glycogen from a patient with liver disease is incubated with orthophosphate, phosphorylase, the transferase, and the debranching enzyme ( α -1,6- glucosidase). The ratio of glucose 1- phosphate to glucose formed in this mixture is 100. What is the most likely enzymatic deficiency in this patient?arrow_forwardOne of the regulators of the TCA cycle is succinyl CoA. Discuss the rationale for this molecule to be used to regulate the TCA cycle [include chemical structures and chemical equations where appropriate]. What is an allosteric inhibitor? How does it operate? For what TCA enzymes does succinyl CoA act as an inhibitor? What is the metabolic role of succinyl CoA? So then why is this molecule a reasonable choice as an inhibitor of the TCA?arrow_forward
- One of the regulators of the TCA cycle is succinyl CoA. Discuss the rationale for this molecule to be used to regulate the TCA cycle. For what TCA enzymes does succinyl CoA act as an inhibitor?arrow_forwardWhat is alpha keto glutarate dehydrogenase complex?. explain very briefly.arrow_forwardCompare the regulation of phosphofuctokinase-1 (PFK- 1) activity and fructose 1,6- bisphosphatase in glycolysis. c) In the B-oxidation of a saturated, even chain fatty acid, four basic steps are involved. Describe these reactions using the degradation of palmitic acid as an example. d) e) Compare the steps involved in the formation of ketone bodies.arrow_forward
- Fourteen NADPH molecules are required to produce one molecules of palmitic acid from acetyl CoA. Substantiate this statement by referring to the enzymatic activities involved in reduction steps during fatty acid synthesis and the number of cycles required to produce palmitic acid from acetyl CoA. How many molecules of ATP is required for the synthesis of palmitic acid from cytosolic acetyl-CoA?arrow_forwardThe peroxisomal enzyme b-ketoacyl–CoA-thiolase does notbind medium-chain acyl-CoA, in contrast to the analogousmitochondrial enzyme. Explain why this phenomenon is anadvantage to the cell.arrow_forwardThe mitochondrial form of carbamoyl phosphate synthetase is allosterically activated by N-acetylglutamate. Briefly describe a rationale for this effect.arrow_forward
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