Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 16, Problem 6P
Under conditions where
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If a fatty acid containing 13 carbons is subjected to Beta oxidation, how many molecules of Acetyl CoA can be produced?
How many acetyl CoA molecules are produced in one cycle of beta oxidation?
How many cycles would it take to catabolize a stearic acid molecule (a fatty acid, [18:0]) into acetyl Co A units?
a)How many acetyl CoA molecules would be produced?
b) How many reduced nucleotides would be produced?
c) If a molecule of glucose produces a net 32 ATP when completely catabolized, which do you think will produce more energy, one molecule of glucose or one molecule of stearic acid? Justify your answer.
Hemp oil contains eicosenoic acid (20:149) as its primary monounsaturated fatty acid. Let's consider the
conversion of a molecule of eicosenoic acid to ẞ-hydroxybutyrate.
What are the ẞ-oxidation products and how many ATP are required during activation for one molecule of lignoceric
acid?
Given the following, how many molecules of 8-hydroxybutyrate can be produced?
2
CoA
CoA
NADH NAD+
H+
OH
B-hydroxybutyrate
Based on the total NADH and FADH2 available after converting lignoceric acid into 8-hydroxybutyrate, what is the typical
yield of ATP that can be produced in the liver? Don't forget to include any ATP required for activation steps.
Chapter 16 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
Ch. 16 - Prob. 1PCh. 16 - If palmitic acid is subjected to complete...Ch. 16 - Calculate the number of ATPs generated by the...Ch. 16 - Prob. 4PCh. 16 - Prob. 5PCh. 16 - Under conditions where ketone bodies are being...Ch. 16 - Prob. 7PCh. 16 - 2-Bromopalmitoyl-CoA inhibits the oxidation of...Ch. 16 - When the identical subunits of chicken liver fatty...Ch. 16 - Prob. 10P
Ch. 16 - Prob. 11PCh. 16 - Prob. 12PCh. 16 - Prob. 13PCh. 16 - Prob. 14PCh. 16 - Prob. 15PCh. 16 - What would be the effect on fatty acid synthesis...Ch. 16 - Prob. 17PCh. 16 - Identify and briefly discuss each mechanism...Ch. 16 - Prob. 19PCh. 16 - Prob. 20PCh. 16 - Prob. 21PCh. 16 - Prob. 22PCh. 16 - Prob. 23PCh. 16 - 24. If mevalonate labeled with 14C in the carboxyl...Ch. 16 - Prob. 25PCh. 16 - Identify a pathway for utilization of the four...Ch. 16 - Prob. 27PCh. 16 - cis-Vaccenate is an 18-carbon unsaturated fatty...Ch. 16 - 29. Briefly describe how cyclic AMP controls...Ch. 16 - Prob. 30PCh. 16 - Prob. 31PCh. 16 - In addition to the pathway described in Figure...Ch. 16 - Prob. 33P
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Most fatty acids have an even number of carbons and, therefore, are completely metabolized to acetyl-CoA. A fatty acid with an odd number of carbonsis metabolized to acetyl-CoA and one equivalent of propionyl-CoA. The following two reactions convert propionyl-CoA into succinyl-CoA, a citric acidcycle intermediate, so it can be further metabolized. Each of the reactions requires a coenzyme. Identify the coenzyme for each step. From what vitaminsare the coenzymes derived? (Hint: see Chapter 23.) COO− COO−CH2CH2methylmalonyl-CoA succinyl-CoA CH3CH2 SCoAarrow_forwardCompare the regulation of phosphofuctokinase-1 (PFK- 1) activity and fructose 1,6- bisphosphatase in glycolysis. c) In the B-oxidation of a saturated, even chain fatty acid, four basic steps are involved. Describe these reactions using the degradation of palmitic acid as an example. d) e) Compare the steps involved in the formation of ketone bodies.arrow_forwardIn the presence of an excess of [14C]acetyl- COA, the metabolic pool of malonyl-CoA becomes labeled at which carbon atom(s)?arrow_forward
- Why would glutamate utilize the oxidative deamination pathway over transamination – especially if removal of NH4+ requires ATP? Would it not be favorable for the body to just use transamination?arrow_forwardKetone bodies are exported from liver for use by other tissues. Because many tissues can synthesize ketone bodies, what enzymatic property of liver might contribute to its special ability to export these compounds?arrow_forwardHow many ATP will be broken down in the complete β-oxidation of this fatty acid?arrow_forward
- When one of the acetyl CoA is processed through the citric acid cycle, how many times does a secondary alcohol group is oxidized to a ketone group?arrow_forwardFourteen NADPH molecules are required to produce one molecules of palmitic acid from acetyl CoA. Substantiate this statement by referring to the enzymatic activities involved in reduction steps during fatty acid synthesis and the number of cycles required to produce palmitic acid from acetyl CoA. How many molecules of ATP is required for the synthesis of palmitic acid from cytosolic acetyl-CoA?arrow_forwardIn order to provide the acetyl-CoA molecules to produce 3 equivalents of palmitic acid, how many glucose molecules would be required?arrow_forward
- Before β-oxidation, fatty acids must be converted to their CoASH derivatives. Explain why this reaction is necessary.arrow_forwardWhat structurtal property of mono- and polyunsaturated fatty acids prevents oxidation of these compounds by the β-oxidation pathway? what additional types of reactions are needed?arrow_forwardHow many more acetyl CoA are generated from stearic acid than from linoleic acid during beta oxidation?arrow_forward
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