Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Textbook Question
Chapter 16, Problem 16P
What would be the effect on fatty acid synthesis of an increase in intramitochondrial oxaloacetate level? Briefly explain your answer
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What would be the effect on fatty acid synthesis of an increase in intramito-
chondrial oxaloacetate level? Briefly explain your answer.
Explain why insulin is required for adipocytes to synthesize triacylglycerols from fatty acids.
Explain why adipocytes need glucose as well as fatty acids in order to synthesize triacylglycerols.
Chapter 16 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
Ch. 16 - Prob. 1PCh. 16 - If palmitic acid is subjected to complete...Ch. 16 - Calculate the number of ATPs generated by the...Ch. 16 - Prob. 4PCh. 16 - Prob. 5PCh. 16 - Under conditions where ketone bodies are being...Ch. 16 - Prob. 7PCh. 16 - 2-Bromopalmitoyl-CoA inhibits the oxidation of...Ch. 16 - When the identical subunits of chicken liver fatty...Ch. 16 - Prob. 10P
Ch. 16 - Prob. 11PCh. 16 - Prob. 12PCh. 16 - Prob. 13PCh. 16 - Prob. 14PCh. 16 - Prob. 15PCh. 16 - What would be the effect on fatty acid synthesis...Ch. 16 - Prob. 17PCh. 16 - Identify and briefly discuss each mechanism...Ch. 16 - Prob. 19PCh. 16 - Prob. 20PCh. 16 - Prob. 21PCh. 16 - Prob. 22PCh. 16 - Prob. 23PCh. 16 - 24. If mevalonate labeled with 14C in the carboxyl...Ch. 16 - Prob. 25PCh. 16 - Identify a pathway for utilization of the four...Ch. 16 - Prob. 27PCh. 16 - cis-Vaccenate is an 18-carbon unsaturated fatty...Ch. 16 - 29. Briefly describe how cyclic AMP controls...Ch. 16 - Prob. 30PCh. 16 - Prob. 31PCh. 16 - In addition to the pathway described in Figure...Ch. 16 - Prob. 33P
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- What impact would a rise in intramitochondrial oxaloacetate levels have on fatty acid synthesis? Justify your response briefly.arrow_forwardThe antidiabetes drugs known as thiazolidinediones induce the production of glycerol kinase in adipocytes. Explain why this would decrease the concentration of serum fatty acids, which are often elevated in diabetics.arrow_forwardWhy are the essential fatty acid associated with low incidence of heart disease? Cite some clinical signs of essential fatty acid deficiency. Explain how aspirin can block the synthesis of prostaglandins?arrow_forward
- Describe the fate of glycerol generated from triacylglycerolhydrolysis in adipocytes.arrow_forwardIn the fasted state, FADH2 and NADH for oxidative phosphorylation are mainly provided by fatty acid oxidation. Explain how fatty acids are mobilised from adipose tissue by the action of glucagon.arrow_forwardBriefly describe the action of glucagons on free fatty acidsarrow_forward
- In type I diabetes mellitus, excessive production of acetyl-CoA may surpass the body’s capacity to oxidize it. As a result, acetoacetate, β-hydroxybutyrate, and acetone (ketone bodies) accumulate. When generated in large amounts, blood pH falls, thereby reducing the capacity of red blood cells to carry oxygen. Explain in general terms how high concentrations of ketone bodies may result in a fatal coma.arrow_forwardExplain why triglycerides have a glucose-sparing effect.arrow_forwardPancreatic β cells express a receptor for fatty acids. Fatty acid binding to the protein appears to stimulate insulin secretion. Does this phenomenon make metabolic sense?arrow_forward
- One metabolic scenario that leads to insulin resistance is the elevation of the conccentration of free fatty acids in skeletal muscle cells. Would you expect increased activity of diacylglycerol acyltransferas (DGAT) to reduce or exacerbate the resistance? Explain.arrow_forwardGlucagon is released from the pancreas in response to low blood glucose levels. It regulates the opposing pathways of glycolysis and gluconeogenesis by altering levels of fructose 2,6-bisphosphate. If glucagon causes a decrease in fructose 2,6-bisphosphate, how does this increase blood glucose levels? Explain..arrow_forwardIn order for a fatty acid stored in an adipocyte to be oxidized by a muscle cell, which of the following will need to be present/utilized? Check all that apply. Multiple answers can be selected Acyl CoA Synthetase CD36 malate-aspartate shuttle dephosphorylated hormone-sensitive lipase GLUT 4arrow_forward
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