To review:
The following:
(a) Neutral Polymorphism.
(b) The significance of the table in the context of examining a family or population for BRCA1 that predispose an individual to cancer.
(c) PM2 polymorphism results in a neutral missense mutation or a silent mutation.
(d) PM3 polymorphism results in a neutral missense mutation or a silent mutation.
Introduction:
Polymorphism occurs when locus of a gene is occupied by two or more alleles within a population. Types of polymorphisms are protein/enzyme polymorphisms and DNA (deoxyribonucleic acid) polymorphisms. DNA polymorphism is further segregated into neutral polymorphisms like Single
Neutral Polymorphisms in BRCA1
Name | Codon Location | Base in codon+ | Frequency in Control Chromosomes |
|||
A | G | T | C | |||
PM3 | 1619 | 1 | 116 | 52 | 0 | 0 |
PM7 | 1190 | 2 | 109 | 53 | 0 | 0 |
PM1 | 317 | 2 | 152 | 10 | 0 | 0 |
PM6 | 878 | 2 | 0 | 0 | 100 | 55 |
PM2 | 1443 | 3 | 0 | 0 | 58 | 115 |
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Essentials of Genetics (9th Edition) - Standalone book
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