An experiment to determine the role of RB1 (retinoblastoma 1) mutation in osteosarcoma. Introduction: RB1 gene is a tumor suppressive gene that regulates cell division and cell proliferation. It codes RB protein that inhibits a transcription factor required for cell division and regulates uncontrolled cell growth. Mutation in one RB1 gene enhances risk of developing various cancers, while a mutation in both copies of the RB1 gene is required to develop cancer.

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Chapter 16, Problem 27PDQ

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An experiment to determine the role of RB1 (retinoblastoma 1) mutation in osteosarcoma.

Introduction:

RB1 gene is a tumor suppressive gene that regulates cell division and cell proliferation. It codes RB protein that inhibits a transcription factor required for cell division and regulates uncontrolled cell growth. Mutation in one RB1 gene enhances risk of developing various cancers, while a mutation in both copies of the RB1 gene is required to develop cancer.

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