Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 14.2, Problem 4COMQ
How does exposing an E. coli cell to glucose affect the regulation of the lac operon via CAP?
a. cAMP binds to CAP and transcription is increased.
b. cAMP binds to CAP and transcription is decreased.
c. cAMP does not bind to CAP and transcription is increased.
d. cAMP does not bind to CAP and transcription is decreased.
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Students have asked these similar questions
Which statement about the transcription attenuation mechanism is TRUE?
1.In some operons (e.g., the his operon), attenuation may be the only regulatory mechanism.
2. Sequences of the trp operon leader RNA resemble an operator.
3. The leader peptide acts by a mechanism that is similar to that of a repressor protein.
4.The leader peptide gene of the trp operon includes no Trp codons.
5. The leader peptide is an enzyme that catalyzes transcription attenuation.
If CAP is bound to the Promoter of the Lac Operon and the repressor protein is not bound to the operator, which of the following is true:
a.Glucose Levels are low & Lactose is absent
b.Glucose is absent & Lactose is present
c.cAMP is low & Lactose is Absent
d.Glucose and Lactose are Present
e.cAMP is low & Lactose is present
What is the role of a substrate that controls a repressible operon?
a.
increase the production of inactive repressor proteins
b.
bind to the repressor protein and activate it
c.
bind to the repressor protein and deactivate it
d.
bind to the promoter region and decrease the affinity of RNA polymerase for the promoter
Chapter 14 Solutions
Genetics: Analysis and Principles
Ch. 14.1 - 1. A repressor is a __________ that _________...Ch. 14.1 - 2. Which of the following combinations will cause...Ch. 14.2 - 1. What is an operon?
a. A site in the DNA where...Ch. 14.2 - The binding of _______ to lac repressor causes lac...Ch. 14.2 - Prob. 3COMQCh. 14.2 - How does exposing an E. coli cell to glucose...Ch. 14.3 - When tryptophan binds to trp repressor, this...Ch. 14.3 - During attenuation, when tryptophan levels are...Ch. 14.3 - Operons involved with the biosynthesis of...Ch. 14.4 - 1. Translation can be regulated by
a....
Ch. 14.4 - Prob. 2COMQCh. 14.5 - 1. For a riboswitch that controls transcription,...Ch. 14 - 1. What is the difference between a constitutive...Ch. 14 - In general, why is it important to regulate genes?...Ch. 14 - Prob. 3CONQCh. 14 - Transcriptional regulation often involves a...Ch. 14 - An operon is repressible-a small effector molecule...Ch. 14 - Prob. 6CONQCh. 14 - 7. What is enzyme adaptation? From a genetic point...Ch. 14 - Prob. 8CONQCh. 14 - Prob. 9CONQCh. 14 - Prob. 10CONQCh. 14 - Mutations may have an effect on the expression of...Ch. 14 - 12. Would a mutation that inactivated lac...Ch. 14 - Prob. 13CONQCh. 14 - 14. As shown in Figure 14.12, four regions within...Ch. 14 - 15. As described in Chapter 13, enzymes known as...Ch. 14 - 16. The combination of a 3–4 stem-loop and a...Ch. 14 - 17. Mutations in tRNA genes can create tRNAs that...Ch. 14 - Prob. 18CONQCh. 14 - Prob. 19CONQCh. 14 - A species of bacteria can synthesize the amino...Ch. 14 - 21. Using three examples, describe how allosteric...Ch. 14 - How are the actions of lac repressor and trp...Ch. 14 - 23. Transcriptional repressor proteins (e.g., lac...Ch. 14 - Answer the following questions that pertain to the...Ch. 14 - Chapter 21 describes a blotting method known as...Ch. 14 - As described in experimental question E2 and also...Ch. 14 - Prob. 4EQCh. 14 - Explain how the data shown in Figure 14.9 indicate...Ch. 14 - Prob. 6EQCh. 14 - Lets suppose you have isolated a mutant strain of...Ch. 14 - Prob. 1QSDCCh. 14 - Prob. 2QSDC
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- Mutations may have an effect on the expression of the lac operon and the trp operon. Would the following mutations have a cis- or transeffect on the expression of the protein-encoding genes in the operon? A. A mutation in the operator site that prevents lac repressor from binding to it B. A mutation in the lacI gene that prevents lac repressor from binding to DNA C. A mutation in the trpL gene that prevents attenuationarrow_forwardHow does the lac operon regulate lactose digestion in bacteria?a. The repressor protein becomes a lactose-digesting enzyme onlywhen lactose is present.b. The repressor protein binds to the lac operon when lactose ispresent, blocking transcription.c. When lactose is present, it binds to the operator region of the lacoperon, activating transcription of the repressor protein gene.d. The repressor protein falls off the lac operon when lactose ispresent, and lactose-digesting genes are expressed.arrow_forwardWhat is one function of TFIIH during transcription? a. Recruiting the TATA-box binding protein to the TATA-box. b. Terminating transcription via factor-dependent termination. c. Capping the 5' end of mRNA with 7-methylguanylate. d. Phosphorylating the CTD of RNA polymerase.arrow_forward
- Which of the following statements about trp operon regulation is TRUE? A. Low trp levels result in trp repressor binding. O B. High trp levels result in transcriptional antitermination. C. Low trp levels cause the ribosome to fall off at the trp codons in the upstream ORF. O D. High trp levels cause the ribosome to fall off at the trp codons in the upstream ORF. O E. Low trp levels result in transcriptional antitermination. QUESTION 34 Consider the following partial diploid for the lac operon system. lacl+ O+ lac Z+Y-A- lacls O+ 1. 2. lac Z-Y+ A+ In this configuration, which of the following statements is TRUE? A. With no lac present, ZYA will all be expressed. B. with lac present none of the genes (ZYA) will be expressed. O C. With no lac present, only YA will be expressed. D. None of these answers is correct. E. With no lac present, only Z will be expressed.arrow_forwardA mutation in the operator region of the trp operon can prevent the trp repressor from binding to this operator. When these mutant cells are placed in a solution containing chicken broth, which of the following happens? a. Tryptophan would bind to the repressor. b. The Repressor would bind to the operator irrespective of the presence of amino acids in the environment. c. The transcription of the trip operon would be inhibited. d. The transcription of the repressor protein is inhibitedarrow_forwardIf lactose isn't present in the environment of an E. coli, what is the state of the lac operon? O a. It is "on" (high transcription) because will glucose will still be present, so the operon's products will be needed. O b. It is "on" (high transcription) because CAP will be bound to the promoter O c. It is "off" (no transcription) because RNA polymerase will be inactivated d. It is "off" (no transcription) and the repressor will be bound to the operatorarrow_forward
- Control of the trp operon relies on which of the following: a. High levels of tryptophan causing a pause (but not termination) in transcription b. Low levels of tryptophan causing a pause (but not termination) in transcription c. Allolactose binding to the inhibitor to prevent it from binding to the promoter d. Tryptophan binding to the inhibitor to prevent it from binding to the promoterarrow_forwardTryptophan (Trp) attenuation is an extra mechanism of regulation of trp operon when trp level is too high. Attenuation causes premature transcription termination. c) Review the region that is responsible for trp attenuation during low trp level.arrow_forwardThere is Hyaluronic acid synthesis occuring in Group X Strep and it is controlled by an operon with 3 genes, called hasXYZ. Based on the 3-line diagram model, a. How many ribosome binding sites are there for the protein? b. How many promoters are there for the genes? c. How many start codons are there for the protein? d. How many RNA Polymerase binding locations are there for the genes? e. How many proteins will be fully functional? f. How many mRNA strands are made?arrow_forward
- Which of the following describes the lac operon in E. coli when lactose and glucose is present in the culture medium? Select one: a. CAP inactive and RNA polymerase does not completely bind to the promoter of the lac operon and transcription of lactose-metabolizing enzymes decreases. b. CAP is active and RNA polymerase binds completely to the promoter of the lac operon and transcription of lactose-metabolizing enzymes decreases. c. Catabolite activator protein (CAP) inactive and RNA polymerase does not completely bind to the promoter of the lac operon and transcription of lactose-metabolizing enzymes increases. d. CAP is active and RNA polymerase binds completely to the promoter of the lac operon and transcription of lactose-metabolizing enzymes increases.arrow_forwardHow does tryptophan regulates its own production? a. When tryptophan levels are high, it binds to the trp repressor, which changes its shape and binds to the operator sequence in the trp operon. b. When tryptophan levels are high, it binds to the trp repressor, which changes its shape and binds to the promoter sequence in the trp operon. c. When tryptophan levels are high, it binds to the trp repressor, which changes its shape and falls off from the operator sequence in the trp operon. d. When tryptophan levels are high, it binds to the trp repressor, which changes its shape and falls off from the promoter sequence in the trp operon.arrow_forwardMutations in the genes of the lac operon might affect the regulation of β-galactosidase synthesis. For each mutation listed below, indicating whether β-galactosidase would be regulated normally, always ON or always OFF. a. Mutation in operator site prevents repressor binding b. Mutation in lacIgene prevents repressor from binding operator c. Mutation in lacIgene prevents repressor from binding allolactose d. Nonsense mutation in lacZgenerearrow_forward
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