Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 14.2, Problem 2COMQ
The binding of _______ to lac repressor causes lac repressor to _______ to the operator site, thereby _______ transcription.
a. glucose, bind, inhibiting
b. allolactose, bind, inhibiting
c. glucose, not bind, increasing
d. allolactose, not bind, increasing
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When tryptophan binds to trp repressor, this causes trp repressor to__________ to the trp operator and ________ transcription.a. bind, inhibitb. not bind, inhibitc. bind, activated. not bind, activate
In the presence of allolactose, the lac repressor
a. binds to the operator.
b. binds to the promoter.
c. cannot bind to the operator.
d. binds to the regulator gene.
E. coli has five genes that code for enzymes that make tryptophan. These genes
are regulated by a single promoter and transcribed as one long gene. The
presence of tryptophan shut down the production of tryptophan by the cell by
binding to the repressor. This changes the repressors shape allowing it to bind to
DNA operator, blocking RNA polymerase and cutting off the production of
tryptophan. a. Describe what woud happen to the operon if some of the cells
had a mutation on the repressor, not allowing it to bind with tryptophan. The
repressor is described as an allosteric protein. What does this mean? b. Does the
tryptophan model demonstrate an inducible or repressible operon? What is your
evidence? *
Chapter 14 Solutions
Genetics: Analysis and Principles
Ch. 14.1 - 1. A repressor is a __________ that _________...Ch. 14.1 - 2. Which of the following combinations will cause...Ch. 14.2 - 1. What is an operon?
a. A site in the DNA where...Ch. 14.2 - The binding of _______ to lac repressor causes lac...Ch. 14.2 - Prob. 3COMQCh. 14.2 - How does exposing an E. coli cell to glucose...Ch. 14.3 - When tryptophan binds to trp repressor, this...Ch. 14.3 - During attenuation, when tryptophan levels are...Ch. 14.3 - Operons involved with the biosynthesis of...Ch. 14.4 - 1. Translation can be regulated by
a....
Ch. 14.4 - Prob. 2COMQCh. 14.5 - 1. For a riboswitch that controls transcription,...Ch. 14 - 1. What is the difference between a constitutive...Ch. 14 - In general, why is it important to regulate genes?...Ch. 14 - Prob. 3CONQCh. 14 - Transcriptional regulation often involves a...Ch. 14 - An operon is repressible-a small effector molecule...Ch. 14 - Prob. 6CONQCh. 14 - 7. What is enzyme adaptation? From a genetic point...Ch. 14 - Prob. 8CONQCh. 14 - Prob. 9CONQCh. 14 - Prob. 10CONQCh. 14 - Mutations may have an effect on the expression of...Ch. 14 - 12. Would a mutation that inactivated lac...Ch. 14 - Prob. 13CONQCh. 14 - 14. As shown in Figure 14.12, four regions within...Ch. 14 - 15. As described in Chapter 13, enzymes known as...Ch. 14 - 16. The combination of a 3–4 stem-loop and a...Ch. 14 - 17. Mutations in tRNA genes can create tRNAs that...Ch. 14 - Prob. 18CONQCh. 14 - Prob. 19CONQCh. 14 - A species of bacteria can synthesize the amino...Ch. 14 - 21. Using three examples, describe how allosteric...Ch. 14 - How are the actions of lac repressor and trp...Ch. 14 - 23. Transcriptional repressor proteins (e.g., lac...Ch. 14 - Answer the following questions that pertain to the...Ch. 14 - Chapter 21 describes a blotting method known as...Ch. 14 - As described in experimental question E2 and also...Ch. 14 - Prob. 4EQCh. 14 - Explain how the data shown in Figure 14.9 indicate...Ch. 14 - Prob. 6EQCh. 14 - Lets suppose you have isolated a mutant strain of...Ch. 14 - Prob. 1QSDCCh. 14 - Prob. 2QSDC
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- Mutations in the genes of the lac operon might affect the regulation of β-galactosidase synthesis. For each mutation listed below, indicating whether β-galactosidase would be regulated normally, always ON or always OFF. a. Mutation in operator site prevents repressor binding b. Mutation in lacIgene prevents repressor from binding operator c. Mutation in lacIgene prevents repressor from binding allolactose d. Nonsense mutation in lacZgenerearrow_forwardWhich of these is used in the transcription of all genes? Choose all correct answers. A. Core promoter B. Proximal promoter C. Distal promoter D. General Transcription Factors E. Regulatory Transcription Factorsarrow_forwardIn order for the lac operon to be triggered, lactose must be present and ________. a. cAMP levels low b. glucose stores depleted c. glucose levels higharrow_forward
- Select the answer that correctly expresses a valid comparison between transcriptional regulation in eukaryotic cell and prokaryotic cells. O A. The glucocorticoid response element is most closely compared to the lac repressor, since these both work in trans to suppress expression of the target gene. OB. The glucocorticoid receptor is most directly compared to the lac repressor protein, since both prevent expression of their target genes but are removed from their binding site after being bound by allolactose. OC. There are no valid comparisons between transcriptional regulation in prokaryotes and eukaryotes. D. The glucocorticoid receptor is most closely compared to the lac operon operator sequence, since these both function in cis to regulate their associated gene. OE. The glucocorticoid response element is most closely compared to the CAP site, since binding of regulatory proteins to these sequences leads to an increase in transcription of the regulated gene.arrow_forwardE. coli has five genes that code for enzymes that make tryptophan. These genes are regulated by a single promoter and transcribed as one long gene. The presence of tryptophan shut down the production of tryptophan by the cell by binding to the repressor. This changes the repressors shape allowing it to bind to DNA operator, blocking RNA polymerase and cutting off the production of tryptophan. a. Describe what would happen to the operon if some of the cells had a mutation on the repressor, not allowing it to bind with tryptophan. The repressor is described as an allosteric protein. What does this mean? b. Does the tryptophan model demonstrate an inducible or repressible operon? What is your evidence?*arrow_forwardIf CAP is bound to the Promoter of the Lac Operon and the repressor protein is not bound to the operator, which of the following is true: a.Glucose Levels are low & Lactose is absent b.Glucose is absent & Lactose is present c.cAMP is low & Lactose is Absent d.Glucose and Lactose are Present e.cAMP is low & Lactose is presentarrow_forward
- Transcriptional repressor proteins (e.g., lac repressor), antisense RNA, and feedback inhibition are three different mechanisms that turn off the expression of genes and gene products. Which of these three mechanisms will be most effective in each of the following situations? A. Shutting down the synthesis of a polypeptide B. Shutting down the synthesis of mRNA C. Shutting off the function of a protein For your answers to parts A–C that list more than one mechanism, which mechanism will be the fastest or the most efficient?arrow_forwardMatch the key complex or product to its related process of regulating gene expression. a. Constitutive genes b. Operons c. The lac operon d. An operator e. A repressor f. The trp operon g. Tryptophan h. A promoter 65. is induced by the presence of lactose in the environment. 66. is a repressed by the presence of tryptophan in the environment. 67. are regions of clustered genes under the control of one promoter.arrow_forwardin E.coli, high glucose levels reduce cyclic AMP (cAMP) levels which then ______ transcription of the lactose operon. a. does NOT change b. decreases c. increasesarrow_forward
- Catabolite activating factor (CAP) senses and the transcription of the lac operon. A. glucose; represses B. lactose; represses C. none of the above D. cAMP; activatesarrow_forwardE. coli are grown on a medium containing lactose. Once glucose is added to the medium, the bacteria stop fermenting lactose. Which of the following BEST explains the observed effect? A. Cellular levels of cAMP are lowB.Glucose is bound to the promoter C. Repressor protein is bound to the operator D. Repressor protein is bound to the promoterarrow_forwardTranscriptional regulation often involves a regulatory protein that binds to a segment of DNA and a small effector molecule that binds to the regulatory protein. Do each of the following terms apply to a regulatory protein, a segment of DNA, or a small effector molecule? A. Repressor B. Inducer C. Operator site D. Corepressor E. Activator F. Attenuator G. Inhibitorarrow_forward
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