Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 14, Problem 12QP
DNA Profiles as Tools for Identification
A PCR-based paternity test is conducted using STRs that consistently produce a unique DNA fragment pattern from a single chromosome. Examining the results of the following Southern blot, which male(s) can be excluded as the father of the child? Which male(s) could be the father of the child?
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show the findings (DNA extraction-gel band; NO/YES) and briefly explain the interpretation of the results
DNA fingerprinting questions: ( Please label each lane so I know which one you refer to) Please explain vividly so I can understand:
•Explain each lane, by analyzing the band pattern and concluding whether it's homozygous or heterozygous for the presence of Alu at the PV92 locus.
•Literature states Alu insertions at PV92 locus are most common in the Asian population (+/+) and mostly not found in Europeans, Americans (-/-)
Reference: https://www.mediafire.com/file/s3nr36ow4bw4udw/DNA+Fingerprinting.docx/file
Regarding STR markers used in forensic science. Tick all the correct statements:
no correct statement
the PCR primers used to amplify STRs are located in the repeat units
PCR primers to amplify STRs are located on both sides of the repeat units
the PCR primers used to amplify STRs are coupled to a fluorochrome which is essential for the detection of amplicons
they are absent from the gonosomes
the allelic frequencies of STR markers vary according to the ethnicity of the individuals genotyped
they are present homogeneously throughout the nuclear genome
Chapter 14 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 14.6 - Suppose you are arrested for a serious crime and a...Ch. 14.6 - Prob. 2EGCh. 14 - Can DNA profiling identify the source of a sample...Ch. 14 - Can DNA profiling identify the source of a sample...Ch. 14 - Can DNA profiling identify the source of a sample...Ch. 14 - Biopharming: Making Human Proteins in Animals...Ch. 14 - Prob. 2QPCh. 14 - Prob. 3QPCh. 14 - Genetically Modified Foods The creation of...Ch. 14 - Prob. 5QP
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- DNA Profiles as Tools for Identification STRs are: a. used for DNA profiles b. repeated sequences present in the human genome c. highly variable in copy number d. all of these e. none of thesearrow_forwardA pcr based paternity test is conducted using STRs that consistently produced a unique DNA fragment pattern from a single chromosome. Examining the results of the following southern blot, which male(s) can be excluded as the father of the child? Which males could be the father?arrow_forwardHow is the color of the spot coverted into useful data if data is collected from a Vicrochip DNA microarray that's from the colors of spots that illuminate when the spots have a laser shine on them? From the following which one is the best option The color of the spot is converted to a number that represents the intensity of green or red, so that the numerical intensity values can be compared between spots by a computer program The color of the spot is bright so that it can be interpreted visually by trained scientists The color of the spot is present on the chip, counted and a ratio of red-yellow and green-yellow is calculated which can be done by hand The color of the spot can't be converted None of the abovearrow_forward
- schematic diagram for the procedure in doing DNA extraction, isolation and quantificationarrow_forwardFrom your knowledge about DNA microarray, answer the following: Why RT-PCR is important in the sample preparation to perform expression microarray experiment?(arrow_forwardsample containing at least one molecule of DNA serves as the starting material for PCR. True Falsearrow_forward
- WHOLE CHROMOSOME ARE NOT ANALYZED IN DNA FINGERPRINTING METHOD.arrow_forwardDNA EXTRACTION Materials: knife 1 cup of fruit Table salt clean piece of cloth or strainer for filtering resealable bag dishwashing liquid 70% rubbing alcohol (chilled) shot glass (or any transparent and narrow container resembling a test tube) How to do the extraction: Before you begin, make sure you have chilled your alcohol in the freezer for at least 3 hours. Room temperature alcohol will not work nearly as well as cold alcohol. Place about 50 mL of alcohol in the freezer to chill it and take it out only when you’re going to need it. (The alcohol will not actually freeze.) 1. The first thing you will need is a sample. Since DNA is found in all living…arrow_forwardThe following figure shows the FBI-style analysis of the genomic DNA of 10 people (1-10), and also of hair found at a crime scence left by the murderer [***]. This analysis involves the PCR amplification of SSR loci, each from a different (nonhomologus) chromosome. The PCR primers are for each SSR locus are labeled with a unique fluorescent molecule. Some bands are thicker because relatively more of the corresponding PCR product was obtained. The figure has dots aligned on both sides to help you find the crucial bands; it will help to use a straight-edge as a guide. The numbers at right are the total number of copies of the SSR locus among the population of 11 samples. Are any of individuals 1-10 probable relatives of the murderer? If so, identify this person and describe the degree of relationship to the criminal.arrow_forward
- The following figure shows the FBI-style analysis of the genomic DNA of 10 people (1-10), and also of hair found at a crime scence left by the murderer [***]. This analysis involves the PCR amplification of SSR loci, each from a different (nonhomologus) chromosome. The PCR primers are for each SSR locus are labeled with a unique fluorescent molecule. Some bands are thicker because relatively more of the corresponding PCR product was obtained. The figure has dots aligned on both sides to help you find the crucial bands; it will help to use a straight-edge as a guide. The numbers at right are the total number of copies of the SSR locus among the population of 11 samples. e. What is the probability that any random male in USA would share the same genotype as the murderer (the match probability)? Assume that all 11 DNA samples analyzed in the diagram are together representative of the USA population as a whole. Show what numbers you would multiply to do this calculation.arrow_forwardThe following figure shows the FBI-style analysis of the genomic DNA of 10 people (1-10), and also of hair found at a crime scence left by the murderer [***]. This analysis involves the PCR amplification of SSR loci, each from a different (nonhomologus) chromosome. The PCR primers are for each SSR locus are labeled with a unique fluorescent molecule. Some bands are thicker because relatively more of the corresponding PCR product was obtained. The figure has dots aligned on both sides to help you find the crucial bands; it will help to use a straight-edge as a guide. The numbers at right are the total number of copies of the SSR locus among the population of 11 samples. Are any of the loci on the Y chromosome? If so, identify this (these) locus (loci) by color.arrow_forwardThe following figure shows the FBI-style analysis of the genomic DNA of 10 people (1-10), and also of hair found at a crime scence left by the murderer [***]. This analysis involves the PCR amplification of SSR loci, each from a different (nonhomologus) chromosome. The PCR primers are for each SSR locus are labeled with a unique fluorescent molecule. Some bands are thicker because relatively more of the corresponding PCR product was obtained. The figure has dots aligned on both sides to help you find the crucial bands; it will help to use a straight-edge as a guide. The numbers at right are the total number of copies of the SSR locus among the population of 11 samples. Are any of the loci on the X chromosome? If so, identify this (these) locus (loci) by color.arrow_forward
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